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pimarane

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By Targets:	Bacterial (1) Drug Derivative (1) Endogenous Metabolite (1) ERK (1) Fungal (1) JNK (1) p38 MAPK (1)
By Research Areas:	Cancer (2) Infection (1) Inflammation/Immunology (1)

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Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N3003

Darutigenol	Others	Inflammation/Immunology
Darutigenol is an ent-pimarane-type diterpenoid isolated from Siegesbecikia orientalis L. .

HY-N8150

Hythiemoside B	Others	Others
Hythiemoside B is isolated as a white amorphous powder. Hythiemoside B is an ent-pimarane glucoside isolated from the aerial part of Siegesbecikia orientalis L. (Asteraceae) .

HY-N1496

15,16-Di-O-acetyldarutoside	Others	Others
15,16-Di-O-acetyldarutoside (compound 5) is an ent-pimarane diterpenoid compound isolated from the ethanol extract of Siegesbeckia orientalis .

HY-N12561

Pestanoid A	ERK p38 MAPK JNK	Others
Pestanoid A is a rearranged pimarane diterpenoid osteoclastogenesis inhibitor with an IC₅₀ of 4.2 μM. Pestanoid A can be isolated from the marine mesophotic zone chalinidae sponge-associated fungus, Pestalotiopsis sp. NBUF145. Pestanoid A inhibits the receptor activator of NF-kB ligand-induced MAPK and NF-κB signaling by suppressing the phosphorylation of ERK1/2-JNK1/2-p38 MAPKs and NF-κB nuclear translocation. Pestanoid A can be used for the study of osteoporosis .

HY-149066

Diaporthein B	Bacterial	Cancer
Diaporthein B is one of the most highly oxidized pimarane diterpenes. Diaporthein B exhibits activity against M. tuberculosis, with a MIC of 3.1 μg/mL. Diaporthein B reveals IC₅₀s of 1.5-3 μM against HCT 116 and LoVo colon cancer cells .

HY-126700

Sphaeropsidin B	Endogenous Metabolite	Cancer
Sphaeropsidin B is a pimarane diterpene and phytotoxin. Sphaeropsidin B can be found in Diplodia cupressi and Diplodia corticola. Sphaeropsidin B induces phytotoxic effects in plants. Sphaeropsidin B can be used for the research of plant injury-related research areas .

HY-N19796

Diaporol I	Drug Derivative	Others
Diaporol I is a pimarane-type sesquiterpene that can be isolated from the mangrove-derived endophytic fungus Diaporthe sp.

HY-N1603

16-o-Acetyldarutigenol	Others	Others
16-o-Acetyldarutigenol (compound 4) is an ent-pimarane diterpenoid compound isolated from the ethanol extract of Siegesbeckia orientalis .

HY-N19881

Drimenal	Fungal	Infection
Drimenal is a pimarane-type natural sesquiterpene with antifungal activity. Drimenal inhibits the growth of yeasts and dermatophytes. Drimenal can be used for the development of pesticide candidates and in research related to fungal infections .

HY-N19883

Drim-9(11)-en-8α-ol	Others	Others
Drim-9(11)-en-8α-ol is a pimarane-type sesquiterpenol. Drim-9(11)-en-8α-ol can be generated via saponification of drim-9(11)-en-8α-yl acetate .

Darutigenol	Classification of Application Fields Terpenoids Bituminaria morisiana (Pignatti & Metlesics) Greuter Diterpenoids Plants Compositae Disease Research Fields Inflammation/Immunology Source Classification	Others
Darutigenol is an ent-pimarane-type diterpenoid isolated from Siegesbecikia orientalis L. .

Hythiemoside B	Classification of Application Fields Terpenoids Other Diseases Diterpenoids Plants Compositae Derris taiwaniana (Hayata) Z. Q. Song Disease Research Fields Source Classification	Others
Hythiemoside B is isolated as a white amorphous powder. Hythiemoside B is an ent-pimarane glucoside isolated from the aerial part of Siegesbecikia orientalis L. (Asteraceae) .

Pestanoid A	Microorganisms Terpenoids Diterpenoids Source Classification	ERK p38 MAPK JNK
Pestanoid A is a rearranged pimarane diterpenoid osteoclastogenesis inhibitor with an IC₅₀ of 4.2 μM. Pestanoid A can be isolated from the marine mesophotic zone chalinidae sponge-associated fungus, Pestalotiopsis sp. NBUF145. Pestanoid A inhibits the receptor activator of NF-kB ligand-induced MAPK and NF-κB signaling by suppressing the phosphorylation of ERK1/2-JNK1/2-p38 MAPKs and NF-κB nuclear translocation. Pestanoid A can be used for the study of osteoporosis .

Sphaeropsidin B	Structural Classification Microorganisms Antibiotics Terpenoids Diterpenoids Source Classification	Endogenous Metabolite
Sphaeropsidin B is a pimarane diterpene and phytotoxin. Sphaeropsidin B can be found in Diplodia cupressi and Diplodia corticola. Sphaeropsidin B induces phytotoxic effects in plants. Sphaeropsidin B can be used for the research of plant injury-related research areas .

Diaporol I	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source Classification	Drug Derivative
Diaporol I is a pimarane-type sesquiterpene that can be isolated from the mangrove-derived endophytic fungus Diaporthe sp.

Drimenal	Structural Classification Natural Products Bazzania trilobata (L.) Gray Lepidoziaceae Plants Source Classification	Fungal
Drimenal is a pimarane-type natural sesquiterpene with antifungal activity. Drimenal inhibits the growth of yeasts and dermatophytes. Drimenal can be used for the development of pesticide candidates and in research related to fungal infections .

Drim-9(11)-en-8α-ol	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source Classification	Others
Drim-9(11)-en-8α-ol is a pimarane-type sesquiterpenol. Drim-9(11)-en-8α-ol can be generated via saponification of drim-9(11)-en-8α-yl acetate .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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pimarane

Inhibitors & Agonists

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Natural
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