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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
pluripotency
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "pluripotency" in MCE Product Catalog:
5
5 Cited Publications
ID-8 is an inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase (DYRK). ID-8 sustains embryonic stem cell (ESC) self-renewal and pluripotency. ID-8 enhances Wnt-mediated hESC survival and proliferation via inhibition of DYRKs .
Synonyms: NSC375009
Displurigen (NSC375009) disrupts human embryonic stem cell pluripotency by targeting HSPA8. Displurigen inhibits ATPase activity of HSP70 (IC50 = 225 μM) .
Cat. No.: HY-P10706
CAS No.: 1588764-53-7
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Cat. No.: HY-15001A
CAS No.: 2319882-01-2
Synonyms: SR1 hydrochloride
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Stemregenin 1 hydrochloride is a purine derivative that antagonizes aryl hydrocarbon receptor signaling in CD34+ cells. IC50 The value is 127 nM. Stemregenin 1 hydrochloride can be used to expand the pluripotency of hematopoietic stem cells (HSC) in stem cell studies .
Cat. No.: HY-174544
Human POU class 5 homeobox 1 (POU5F1) mRNA encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis.
Cat. No.: HY-174574
Human NANOG mRNA encodes the human Nanog homeobox (NANOG) protein, a DNA binding homeobox transcription factor that involved in embryonic stem (ES) cell proliferation, renewal, and pluripotency. NANOG can block ES cell differentiation and autorepress its own expression in differentiating cells.
Cat. No.: HY-D3525
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BDL-E5 is a fluorescent probe for detecting live induced pluripotent stem cells at the early reprogramming stage. Its detection mechanism involves specific binding to authentic reprogramming cells, which exhibit increased expression of pluripotency and epithelial genes and decreased expression of mesenchymal genes compared to non-reprogramming cells; it appears to co-localize more significantly with the Golgi complex than other organelle markers in reprogramming cells, and it does not require washing after staining to reduce background signals; fluorescence is generated upon binding to these early reprogramming cells, with positive cells appearing 7 days before iPS colonies are visible and stain positive for the conventional pluripotent marker TRA-1-60, and sorting BDL-E5-positive cells enriches populations that generate higher numbers and quality of iPS colonies. Its detection wavelength is Ex/Em = 578/599 nm .
Cat. No.: HY-111002R
CAS No.: 96156-26-2
Synonyms: NSC375009 (Standard)
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Displurigen (Standard) is the analytical standard of Displurigen (HY-111002). This product is intended for research and analytical applications. Displurigen (NSC375009) disrupts human embryonic stem cell pluripotency by targeting HSPA8. Displurigen inhibits ATPase activity of HSP70 (IC50 = 225 μM) .
Cat. No.: HY-K6019
MCE Stem Cell Cryopreservation Medium is a ready-to-use, serum-free Cryopreservation Medium optimized for human pluripotent stem cells (PSCs). PSCs preserved with this medium exhibit high post-thaw viability (> 90%) and stable expression of pluripotency markers such as OCT4 and NANOG, providing consistent and reliable cell sources for subsequent expansion and differentiation. This product is suitable for long-term, stable storage of PSCs and downstream applications.
Cat. No.: HY-L017
2,884 compounds
Adult stem cells are important for tissue homeostasis and regeneration due to their ability to self-renew and generate multiple types of differentiated daughters. Self-renewal is reflected by their capacity to undergo multiple/limitless divisions. Several signaling pathways are involved in self-renewal of stem cells, that is, Notch, Wnt, and Hedgehog pathways or Polycomb family proteins. Recent studies mainly focus on cancer stem cell (CSCs), induced pluripotent stem cell (iPSCs), neural stem cell and maintenance of embryonic stem cell pluripotency. Among them, CSCs have been believed to be responsible for tumor initiation, growth, and recurrence that have implications for cancer therapy.
MCE owns a unique collection of 2,884 compounds that can be used for stem cell regulatory and signaling pathway research.
Cat. No.: HY-P11870
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Cat. No.: HY-12299G
CAS No.: 837422-57-8
Synonyms: Dual LCK/SRC inhibitor (GMP)
Cat. No.: HY-13689G
CAS No.: 133053-19-7
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
