147591-46-6
147591-46-6
Chemical Structure
ID-8
- CAS No.: 147591-46-6
- Formula:C16H14N2O4
- Molecular Weight:298.29
IUPAC Name: 1-(4-methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol
InChIKey: VVZNWYXIOADGSW-UHFFFAOYSA-N
SMILES: OC1=CC2=C(C=C1)C([N+]([O-])=O)=C(C)N2C3=CC=C(OC)C=C3
Biological Activity: ID-8 is an inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase (DYRK). ID-8 sustains embryonic stem cell (ESC) self-renewal and pluripotency. ID-8 enhances Wnt-mediated hESC survival and proliferation via inhibition of DYRKs[1][2].
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ID-8 | 99.21% | ID-8 is an inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase (DYRK). ID-8 sustains embryonic stem cell (ESC) self-renewal and pluripotency. ID-8 enhances Wnt-mediated hESC survival and proliferation via inhibition of DYRKs. | ||||||||||||||||||||
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References
- [1]. Hasegawa, K., et al., Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion. Stem Cells Transl Med, 2012. 1(1): p. 18-28. [Content Brief]
- [2]. Miyabayashi, T., et al., Indole derivatives sustain embryonic stem cell self-renewal in long-term culture. Biosci Biotechnol Biochem, 2008. 72(5): p. 1242-8. [Content Brief]
