1. Protein Tyrosine Kinase/RTK
  2. DYRK
  3. ID-8


Cat. No.: HY-15838 Purity: 99.71%
Handling Instructions

ID-8 is a DYRK inhibitor, and sustains embryonic stem cell self-renewal in long-term culture.

For research use only. We do not sell to patients.

ID-8 Chemical Structure

ID-8 Chemical Structure

CAS No. : 147591-46-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 70 In-stock
Estimated Time of Arrival: December 31
50 mg USD 200 In-stock
Estimated Time of Arrival: December 31
100 mg USD 360 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

    ID-8 purchased from MCE. Usage Cited in: Biochem Biophys Res Commun. 2020 Jan 24. pii: S0006-291X(20)30143-1.B

    Western blot analysis of Tcf7l1 protein levels in mESCs pre-treated with the indicative different small molecules for 1 h and then treated with CHIR for 24 h.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review


    ID-8 is a DYRK inhibitor, and sustains embryonic stem cell self-renewal in long-term culture. IC50 Value: Target: DYRK in vitro: the combination of Wnt and ID-8 enhanced hESC replating efficiency, and colonies expressed ALP and displayed undifferentiated morphology. members of the DYRK family are direct targets of ID-8 and that ID-8 enhances Wnt-mediated hESC survival and proliferation via inhibition of DYRKs [1]. ID-8 stimulated proliferation at a steady rate similar to LIF. ID-8 is required to maintain nanog, Sox2, and Rex-1 gene expression [2]. In vivo:

    Molecular Weight




    CAS No.





    Room temperature in continental US; may vary elsewhere.

    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 47 mg/mL (157.56 mM)

    *"≥" means soluble, but saturation unknown.

    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.3524 mL 16.7622 mL 33.5244 mL
    5 mM 0.6705 mL 3.3524 mL 6.7049 mL
    10 mM 0.3352 mL 1.6762 mL 3.3524 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: 2.5 mg/mL (8.38 mM); Suspended solution; Need ultrasonic

    *All of the co-solvents are provided by MCE.
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    • Molarity Calculator

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    ID-8ID8ID 8DYRKDual specificity tyrosine phosphorylation regulated kinaseDual specificity tyrosine regulated kinaseInhibitorinhibitorinhibit

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