1. Protein Tyrosine Kinase/RTK
  2. DYRK
  3. ID-8

ID-8 

Cat. No.: HY-15838 Purity: 99.71%
Handling Instructions

ID-8 is a DYRK inhibitor, and sustains embryonic stem cell self-renewal in long-term culture.

For research use only. We do not sell to patients.

ID-8 Chemical Structure

ID-8 Chemical Structure

CAS No. : 147591-46-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 90 In-stock
Estimated Time of Arrival: December 31
50 mg USD 360 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Description

ID-8 is a DYRK inhibitor, and sustains embryonic stem cell self-renewal in long-term culture. IC50 Value: Target: DYRK in vitro: the combination of Wnt and ID-8 enhanced hESC replating efficiency, and colonies expressed ALP and displayed undifferentiated morphology. members of the DYRK family are direct targets of ID-8 and that ID-8 enhances Wnt-mediated hESC survival and proliferation via inhibition of DYRKs [1]. ID-8 stimulated proliferation at a steady rate similar to LIF. ID-8 is required to maintain nanog, Sox2, and Rex-1 gene expression [2]. In vivo:

Molecular Weight

298.29

Formula

C₁₆H₁₄N₂O₄

CAS No.

147591-46-6

SMILES

OC1=CC2=C(C=C1)C([N+]([O-])=O)=C(C)N2C3=CC=C(OC)C=C3

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 47 mg/mL (157.56 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3524 mL 16.7622 mL 33.5244 mL
5 mM 0.6705 mL 3.3524 mL 6.7049 mL
10 mM 0.3352 mL 1.6762 mL 3.3524 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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ID-8
Cat. No.:
HY-15838
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