68 Results for "

pure

" in MedChemExpress (MCE) Product Catalog:
Products (68)

68 Results for "pure" in MCE Product Catalog:

139
Fulvestrant
Fulvestrant
0 Images
139 Publications Verification
Art. -Nr.: HY-13636
CAS. Nr.: 129453-61-8
Reinheit:  99.92%
Synonyms: ICI 182780; ZD 9238; ZM 182780
Target:  

Estrogen Receptor/ERR Autophagy Apoptosis

Forschungsgebiete:  

Inflammation/Immunology Cancer

Fulvestrant (ICI 182780) is a pure antiestrogen and a potent estrogen receptor (ER) antagonist with an IC50 of 9.4 nM. Fulvestrant is also a GPR30 agonist. Fulvestrant effectively inhibits the growth of ER-positive MCF-7 cells with an IC50 of 0.29 nM. Fulvestrant also induces autophagy and has antitumor efficacy .
139
Fulvestrant (Standard)
Fulvestrant (Standard)
0 Images
139 Publications Verification
Art. -Nr.: HY-13636R
CAS. Nr.: 129453-61-8
Reinheit:  99.71%
Synonyms: ICI 182780(Standard); ZD 9238(Standard); ZM 182780 (Standard)
Target:  

Reference Standards Estrogen Receptor/ERR Autophagy Apoptosis

Forschungsgebiete:  

Cancer

Fulvestrant (Standard) is the analytical standard of Fulvestrant. This product is intended for research and analytical applications. Fulvestrant (ICI 182780) is a pure antiestrogen and a potent estrogen receptor (ER) antagonist with an IC50 of 9.4 nM. Fulvestrant is also a GPR30 agonist. Fulvestrant effectively inhibits the growth of ER-positive MCF-7 cells with an IC50 of 0.29 nM. Fulvestrant also induces autophagy and has antitumor efficacy .
14
Bafetinib
Bafetinib
0 Images
14 Cited Publications
Art. -Nr.: HY-50868
CAS. Nr.: 859212-16-1
Synonyms: INNO-406; NS-187
Target:  

Bcr-Abl Src Apoptosis

Forschungsgebiete:  

Cancer

Bafetinib is an orally active Lyn/Bcr-Abl tyrosine kinase inhibitor. Bafetinib enhances the activity of several pro-apoptotic Bcl-2 homology (BH) 3-pure proteins (Bim, Bad, Bmf, and Bik) through intrinsic apoptotic pathways regulated by the Bcl-2 family, and induces apoptosis of Ph + leukemia cells. Bafetinib has antitumor activity .
11
3,3'-Diindolylmethane
3,3'-Diindolylmethane
0 Images
11 Cited Publications
Art. -Nr.: HY-15758
CAS. Nr.: 1968-05-4
Reinheit:  99.89%
Synonyms: DIM; Arundine; HB 236
Category:  

Alkaloids other families Plants Disease Research Fields Cancer Alkaloid Dimers

Target:  

Androgen Receptor Autophagy

3,3'-Diindolylmethane is a strong, pure androgen receptor (AR) antagonist.
2
Acolbifene
Acolbifene
0 Images
2 Cited Publications
Art. -Nr.: HY-16023A
CAS. Nr.: 182167-02-8
Synonyms: EM-652; SCH 57068
Target:  

Estrogen Receptor/ERR

Forschungsgebiete:  

Cancer

Acolbifene (EM-652), the active metabolite of EM800, is an orally active pure antiestrogen and selective estrogen receptor antagonist. Acolbifene (EM-652) inhibits estradiol (E2)-induced transcriptional activity of ERα (IC50 = 2 nM) and ERβ (IC50 = 0.4 nM). Acolbifene (EM-652) possesses potent and pure anticarcinogenic properties .
2
Carboxyaminoimidazole ribotide
Carboxyaminoimidazole ribotide
0 Images
2 Cited Publications
Art. -Nr.: HY-133154
CAS. Nr.: 6001-14-5
Reinheit:  98.31%
Synonyms: CAIR; 4-Carboxy-AIR
Category:  

Infection Natural Products Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite

Carboxyaminoimidazole ribotide (CAIR) is a metabolite of E. coli. Carboxyaminoimidazole ribotide can be used to detect distinctive features of E. coli PurE active site and synthesis fungal de novo purine .
2
Acolbifene hydrochloride
Acolbifene hydrochloride
0 Images
2 Cited Publications
Art. -Nr.: HY-16023
CAS. Nr.: 252555-01-4
Synonyms: EM-652 hydrochloride; SCH 57068 hydrochloride
Target:  

Estrogen Receptor/ERR

Forschungsgebiete:  

Cancer

Acolbifene (EM-652) hydrochloride, an active metabolite of EM800, is an orally active, cancer-preventing selective estrogen receptor modulator (SERM). Acolbifene (EM-652) hydrochloride inhibits estradiol (E2)-induced transcriptional activity of ERα (IC50=2 nM) and ERβ (IC50=0.4 nM). Acolbifene (EM-652) hydrochloride exerts a potent and pure antiestrogenic action in the mammary gland and uterus. Anticarcinogenic properties .
1
Imlunestrant
Imlunestrant
0 Images
1 Cited Publications
Art. -Nr.: HY-145572
CAS. Nr.: 2408840-26-4
Reinheit:  99.02%
Synonyms: LY-3484356
Target:  

Estrogen Receptor/ERR

Forschungsgebiete:  

Cancer

Imlunestrant (LY-3484356) is an orally active, potent and selective estrogen receptor degrader (SERD) with pure antagonistic properties. Imlunestrant results in sustained inhibition of ER-dependent gene transcription and cell growth. Imlunestrant can be used for the research of ER-positive (ER+) advanced breast cancer (aBC) and endometrial endometrioid cancer (EEC) .
1
Imlunestrant tosylate
Imlunestrant tosylate
0 Images
1 Cited Publications
Art. -Nr.: HY-145572A
CAS. Nr.: 2408840-41-3
Reinheit:  98.54%
Synonyms: LY-3484356 tosylate
Target:  

Estrogen Receptor/ERR

Forschungsgebiete:  

Cancer

Imlunestrant (LY-3484356) tosylate is an orally active, potent and selective estrogen receptor degrader (SERD) with pure antagonistic properties. Imlunestrant tosylate results in sustained inhibition of ER-dependent gene transcription and cell growth. Imlunestrant tosylate can be used for the research of ER-positive (ER+) advanced breast cancer (aBC) and endometrial endometrioid cancer (EEC) .
1
ZK168281
ZK168281
0 Images
1 Cited Publications
Art. -Nr.: HY-12407
CAS. Nr.: 186371-96-0
Reinheit:  ≥98.0%
Target:  

VD/VDR

Forschungsgebiete:  

Metabolic Disease

ZK168281 is a 25-carboxylic ester 1α,25(OH)2D3 analog and a pure VDR antagonist with a Kd value of 0.1 nM. ZK168281 is an effective inhibitor of the coactivator (CoA) interaction of its receptor .
Tricaprilin
Tricaprilin
0 Images
Art. -Nr.: HY-B1804
CAS. Nr.: 538-23-8
Synonyms: Trioctanoin; Glyceryl trioctanoate
Category:  

Natural Products Neurological Disease Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite

Tricaprilin (Trioctanoin) is an orally active and well tolerated ketogenic agent that safely induces ketosis. Tricaprilin restores brain electrical activity and metabolism to help counteract neuroinflammation in migraine. Tricaprilin is promising for research of migraine prevention and Alzheimer’s disease (AD). Tricaprilin is a pure C8 medium chain triglyceride (MCT) .
Ammonium carbonate, 99%
Ammonium carbonate, 99%
0 Images
Art. -Nr.: HY-Y0286
CAS. Nr.: 506-87-6
Synonyms: Hartshorn salt, 99%
Ammonium carbonate (Ammonium carbonate), 99% is a solid amino compound that functions as a buffer, pH regulator, pore-forming agent, and electrocatalytic oxidation substrate. Ammonium carbonate, 99% is a GRAS-grade direct food additive with no restricted daily intake specified by FAO/WHO, and it shows no acute skin toxicity, clinical signs of toxicity, or effects on body weight in rats. Ammonium carbonate, 99% undergoes electrocatalytic oxidation in alkaline solutions with a Pt/C catalyst (carbonate adsorption interferes with activity). Ammonium carbonate, 99% can serve as a fuel for low-temperature polymer fuel cells and anion exchange membrane fuel cells (with performance superior to pure ammonia), and can also form pores in the carrier-free Pt cathode catalyst layer after low-temperature decomposition, thereby enhancing catalyst activity under low-humidity conditions and the performance of proton exchange membrane fuel cells .
Lusianthridin
Lusianthridin
0 Images
Art. -Nr.: HY-121418
CAS. Nr.: 87530-30-1
Reinheit:  ≥98.0%
Category:  

Natural Products other families Phenols Polyphenols Plants Disease Research Fields Cancer

Target:  

c-Myc

Lusianthridin, a pure compound from Dendrobium venustum, have an anti-migratory effect. Lusianthridin enhances c-Myc degradation through the inhibition of Src-STAT3 signaling .
Fulvestrant-d3
Fulvestrant-d3
0 Images
Art. -Nr.: HY-13636S
Reinheit:  97.47%
Synonyms: ICI 182780-d3; ZD 9238-d3; ZM 182780-d3
Fulvestrant-d3 is the deuterium labeled Fulvestrant. Fulvestrant (ICI 182780) is a pure antiestrogen and a potent estrogen receptor (ER) antagonist with an IC50 of 9.4 nM. Fulvestrant is also a GPR30 agonist. Fulvestrant effectively inhibits the growth of ER-positive MCF-7 cells with an IC50 of 0.29 nM. Fulvestrant also induces autophagy and has antitumor efficacy .
3,3'-Diindolylmethane (Standard)
3,3'-Diindolylmethane (Standard)
0 Images
Art. -Nr.: HY-15758R
CAS. Nr.: 1968-05-4
Synonyms: DIM (Standard); Arundine (Standard); HB 236 (Standard)
Category:  

Alkaloids other families Plants Alkaloid Dimers

Target:  

Reference Standards Androgen Receptor Autophagy

3,3'-Diindolylmethane (Standard) is the analytical standard of 3,3'-Diindolylmethane. This product is intended for research and analytical applications. 3,3'-Diindolylmethane is a strong, pure androgen receptor (AR) antagonist.
Fulvestrant-d5
Fulvestrant-d5
0 Images
Art. -Nr.: HY-13636S1
Synonyms: ICI 182780-d5; ZD 9238-d5; ZM 182780-d5
Fulvestrant-d5 (ICI 182780-d5) is a isotope of Fulvestrant (HY-13636) . Fulvestrant (ICI 182780) is a pure antiestrogen and a potent estrogen receptor (ER) antagonist with an IC50 of 9.4 nM. Fulvestrant is also a GPR30 agonist. Fulvestrant effectively inhibits the growth of ER-positive MCF-7 cells with an IC50 of 0.29 nM. Fulvestrant also induces autophagy and has antitumor efficacy.
Ivabradine-d6 hydrochloride
Ivabradine-d6 hydrochloride
0 Images
Art. -Nr.: HY-B0162AS
CAS. Nr.: 2070009-63-9
Ivabradine-d6 hydrochloride is the deuterium labeled Ivabradine hydrochloride. Ivabradine hydrochloride is a new If inhibitor with IC50 of 2.9 μM, and used as a pure heart rate lowering agent.
Fulvestrant 3-β-D-Glucuronide
Fulvestrant 3-β-D-Glucuronide
0 Images
Art. -Nr.: HY-148225
CAS. Nr.: 261506-27-8
Reinheit:  94.79%
Target:  

Drug Metabolite

Forschungsgebiete:  

Cancer

Fulvestrant 3-β-D-Glucuronide, a metabolite, is glucuronide and sulfate conjugates of Fulvestrant (HY-13636), a pure anti-estrogenic steroid. Fulvestrant 3-β-D-Glucuronide can be used for the research of breast cancer .
Cremophor EL-10
Cremophor EL-10
0 Images
Art. -Nr.: HY-Y1890B
CAS. Nr.: 61791-12-6
Cremophor EL-10 is a nonionic polyoxyethylene castor oil surfactant with multiple functions including organic solubilizer, mixed zinc anode corrosion inhibitor and dendrite growth inhibitor. By forming a physical barrier to block electrolyte contact and constructing oriented hydration channels to reduce the desolvation energy barrier of Zn 2+ , Cremophor EL-10 achieves a corrosion inhibition efficiency of over 99%. Cremophor EL-10 exerts no significant effects on the mitochondrial activity and cell viability of epithelial cells, making it suitable for in vitro drug delivery and biopharmaceutical research at concentrations ≤10% v/v. However, Cremophor EL-10 may induce sustained non-endothelium-dependent contraction in rat aortic rings and exert concentration-dependent inhibitory effects on acetylcholine-induced endothelium-dependent relaxation responses .
Tricaprilin-13C3
Tricaprilin-13C3
0 Images
Art. -Nr.: HY-B1804S
CAS. Nr.: 65402-55-3
Synonyms: Trioctanoin-13C3; Glyceryl trioctanoate-13C3
Tricaprilin- 13C3 (Trioctanoin- 13C3) is a 13C-labeled Tricaprilin (HY-B1804) . Tricaprilin is an orally active and well tolerated ketogenic agent that safely induces ketosis. Tricaprilin restores brain electrical activity and metabolism to help counteract neuroinflammation in migraine. Tricaprilin is promising for research of migraine prevention and Alzheimer’s disease (AD). Tricaprilin is a pure C8 medium chain triglyceride (MCT) .
Assay Types