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tetrameric

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By Targets:	Biochemical Assay Reagents (2) COX (1) GLP Receptor (1) HIV (1) Insecticide (1) Phospholipase (1) PKC (1) TNF Receptor (1)
By Research Areas:	Cancer (1) Inflammation/Immunology (3) Metabolic Disease (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N9536

Cinnamtannin A2	GLP Receptor	Metabolic Disease
Cinnamtannin A2, a tetrameric procyanidin, can increases GLP-1 and insulin secretion in mice. Cinnamtannin A2 could upregulate the expression of corticotrophin releasing hormone. Cinnamtannin A2 exhibits antioxidant, anti-diabetic and nephroprotective effect .

HY-106381A

*Aurothiomalate tetramer* sodium**	PKC	Inflammation/Immunology
Aurothiomalate tetramer sodium, an Aurothiomalate sodium (HY-106381) tetrameric form, is antiarthritic gold agent. Aurothiomalate sodium is a potent and selective oncogenic PKCι signaling inhibitor .

HY-167826

Spiropidion	Insecticide	Others
Spiropidion is a novel tetrameric acid pesticide with highly effective insecticidal and acaricidal activity .

HY-N16481

Parameritannin A-1	COX Phospholipase	Inflammation/Immunology
Parameritannin A-1 is a tetrameric proanthocyanidin (PAC) that can be isolated from the bark of Parameria laevigata Moldenke (Apocynaceae). Parameritannin A-1 is a COX-2 inhibitor. Parameritannin A-1 also inhibits the activity of phospholipase A₂ (PLA₂) .

HY-137618B

Rp-dGTPαS	HIV	Others
Rp-dGTPαS is the nucleotide substrate of SAMHD1 and is one of the enantiomers of the dNTPαS nucleotide. SAMHD1 is an essential regulator of cellular dNTPs that limits virus (HIV-1, etc.) replication in the CD4+ myeloid lineage and resting T cells. The SAMHD1 tetrameric complex catalyzes the hydrolysis of Rp-dGTPαS into 2'-deoxynucleosides and triphosphates .

HY-169805

Pulcherosine	Biochemical Assay Reagents	Others
Pulcherosine is an intermediate in the conversion of isodityrosine to tetrameric diisodityrosine.

HY-131575

Sedoheptulose 1,7-diphosphate	Biochemical Assay Reagents	Others
Sedoheptulose 1,7-diphosphate is a substrate for fructose bisphosphatase form B from Synechococcus leopoliensis. Sedoheptulose 1,7-diphosphate undergoes hydrolysis at the carbon 1-ester, stabilizes the activated tetrameric state of fructose bisphosphatase form B, and prevents the enzyme’s slow inactivation. Sedoheptulose 1,7-diphosphate supports fructose bisphosphatase form B-mediated bisphosphatase reactions within the reductive pentose phosphate cycle .

HY-P992473

TAS266	TNF Receptor	Inflammation/Immunology Cancer
TAS266 is a tetrameric nanobody agonist targeting DR5. TAS266 selectively induces cancer cell death. TAS266 triggers sustained tumor regression in xenograft models and also elicits immunogenic responses including antibody binding. TAS266 exhibits superior anti-tumor efficacy compared with traditional DR5-targeting strategies. TAS266 can be used in research related to pancreatic cancer and advanced solid tumors .

Cat. No.	Product Name	Target	Research Area	Image

HY-P992473

TAS266	TNF Receptor	Inflammation/Immunology Cancer
TAS266 is a tetrameric nanobody agonist targeting DR5. TAS266 selectively induces cancer cell death. TAS266 triggers sustained tumor regression in xenograft models and also elicits immunogenic responses including antibody binding. TAS266 exhibits superior anti-tumor efficacy compared with traditional DR5-targeting strategies. TAS266 can be used in research related to pancreatic cancer and advanced solid tumors .

Cinnamtannin A2	Flavanonols Flavonoids Cinnamomum cassia (L.) D. Don Classification of Application Fields Phenols Polyphenols Metabolic Disease Plants Lauraceae Biflavones Disease Research Fields Source Classification	GLP Receptor
Cinnamtannin A2, a tetrameric procyanidin, can increases GLP-1 and insulin secretion in mice. Cinnamtannin A2 could upregulate the expression of corticotrophin releasing hormone. Cinnamtannin A2 exhibits antioxidant, anti-diabetic and nephroprotective effect .

Parameritannin A-1	Apocynaceae Structural Classification Phenols Polyphenols Parameria laevigata (Juss.) Moldenke Plants Source Classification	COX Phospholipase
Parameritannin A-1 is a tetrameric proanthocyanidin (PAC) that can be isolated from the bark of Parameria laevigata Moldenke (Apocynaceae). Parameritannin A-1 is a COX-2 inhibitor. Parameritannin A-1 also inhibits the activity of phospholipase A₂ (PLA₂) .

Sedoheptulose 1,7-diphosphate	Structural Classification Natural Products Microorganisms Endogenous metabolite Source Classification	Biochemical Assay Reagents
Sedoheptulose 1,7-diphosphate is a substrate for fructose bisphosphatase form B from Synechococcus leopoliensis. Sedoheptulose 1,7-diphosphate undergoes hydrolysis at the carbon 1-ester, stabilizes the activated tetrameric state of fructose bisphosphatase form B, and prevents the enzyme’s slow inactivation. Sedoheptulose 1,7-diphosphate supports fructose bisphosphatase form B-mediated bisphosphatase reactions within the reductive pentose phosphate cycle .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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tetrameric

Inhibitors & Agonists

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