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wasting

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35

Inhibitors & Agonists

1

Screening Libraries

7

Biochemical Assay Reagents

2

Inhibitory Antibodies

3

Natural
Products

2

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-112288
    C188-9
    Maximum Cited Publications
    32 Publications Verification

    TTI-101

    STAT Apoptosis DNA Methyltransferase Metabolic Disease Inflammation/Immunology Cancer
    C188-9 (TTI-101) is a STAT3 inhibitor with a Kd value of 4.7 nM. C188-9 targets the SH2 domain of STAT3, blocks the processes of STAT3 ligand binding, receptor recruitment, homodimerization and phosphorylation, and regulates STAT3-mediated genes associated with tumorigenesis and radioresistance. C188-9 regulates STAT1-mediated genes related to radioresistance and reduces the activation level of STAT1. C188-9 downregulates the expression of DNMT1, enhances DAC-induced demethylation and re-expression of RASSF1A, and simultaneously potentiates the anti-tumor effect of DAC on pancreatic cancer cells. C188-9 inhibits both anchorage-dependent and anchorage-independent growth of cancer cells, induces Apoptosis, blocks the growth of tumor xenografts, and suppresses muscle atrophy. C188-9 maintains muscle mass, increases body weight and improves grip strength in tumor-bearing mice. C188-9 can be used in research related to head and neck squamous cell carcinoma, pancreatic cancer, sepsis-related skeletal muscle wasting, non-small cell lung cancer, acute myeloid leukemia and cancer cachexia .
    C188-9
  • HY-13676
    Megestrol acetate
    2 Publications Verification

    Progesterone Receptor Autophagy HIV Endocrinology Cancer
    Megestrol acetate is a synthetic and orally active progesteronal agent. Megestrol acetate is effective as an appetite stimulant for wasting syndromes such as cachexia. Megestrol acetate decreases nuclear and cytosol androgen receptors human BPH tissue. Megestrol acetate has the potential for HIV study and downregulates autophagic catabolic pathway .
    Megestrol acetate
  • HY-P99388
    Trevogrumab
    1 Publications Verification

    REGN-1033; SAR391786

    TGF-beta/Smad Metabolic Disease
    Trevogrumab (REGN-1033) is a monoclonal antibody targeting GDF8 (growth differentiation factor 8, also known as myostatin). Trevogrumab is used in research on muscle wasting conditions, including disuse atrophy, chronic diseases, and changes in food and nutrient intake .
    Trevogrumab
  • HY-123012

    LY-488756

    Adrenergic Receptor Others
    Lubabegron is a potent modulator of β-adrenergic receptor (β-AR). Lubabegron demonstrates antagonistic behavior at the β1 and β 2 receptor subtypes and agonistic behavior at the β 3 receptor subtype in cattle. Lubabegron reduces NH3 gas emissions from an animal or its waste. Lubabegron is available as an animal supplement .
    Lubabegron
  • HY-P99370
    Landogrozumab
    1 Publications Verification

    LY2495655; Anti-GDF8 / Myostatin Reference Antibody (landogrozumab)

    TGF-beta/Smad Inflammation/Immunology Cancer
    Landogrozumab (LY2495655) is an humanized anti-myostatin monoclonal antibody. Landogrozumab effectively improves muscle volume, hand grip strength and function. Landogrozumab can be used for the research of muscle wasting disease .
    Landogrozumab
  • HY-E70387

    Endogenous Metabolite Others
    Ligninase is a general term for extracellular heme-containing peroxidases produced by Phanerochaete chrysosporium. Ligninase can catalyze lignin degradation. Ligninase can be used in waste treatment and detoxification of environmental pollutants .
    Ligninase
  • HY-Y1219H

    Biochemical Assay Reagents Others
    Silica gel, high-purity grade, 200-400 mesh is a low-density, high-surface-area, high-purity inert additive that can be used to prepare chromatographic column sieve plates based on the sol-gel method. Silica gel, high-purity grade prevents DNA degradation by absorbing water from plant leaves, and is suitable for the preservation of field-collected samples for subsequent DNA extraction, restriction endonuclease digestion, PCR amplification and gene sequencing. It can also be reused after being saturated with water. Silica gel, high-purity grade can provide a non-toxic, inert aquatic environment for embedded cells, allowing nutrients, oxygen and metabolic waste to diffuse freely and blocking external pollution, thereby maintaining the activity of fibroblasts and epithelial cells .
    Silica gel, high-purity grade, 200-400 mesh
  • HY-165151

    Urochrome hydrochloride

    Endogenous Metabolite Others
    Urobilin hydrochloride is the metabolite of Hemoglobin (HY-P2995), that can be excreted through urine and feces in many mammals. Urobilin hydrochloride can be used as an indicator of human waste pollution .
    Urobilin hydrochloride
  • HY-Y0319B1
    Potassium acetate, for molecular biology
    1 Publications Verification

    Environmental Pollutants Biochemical Assay Reagents Others
    Potassium acetate, for molecular biology is an acetate salt commonly used as a deicing agent, food preservative and potassium source. Potassium acetate, for molecular biology can serve as an activator for preparing waste tea-based activated carbon, and is applied to the adsorption of Acid Blue 25 dye .
    Potassium acetate, for molecular biology
  • HY-P2816

    Biochemical Assay Reagents Others
    Xylanase is an enzyme targeting 1,4-β-D-xylan that randomly cleaves the β-1,4 backbone of xylan, a complex polysaccharide in plant cell walls. Xylanase finds applications in the food, feed and industrial sectors, including pulp and paper processing, baking, animal feed improvement, and biotransformation of waste .
    Xylanase
  • HY-13676R
    Megestrol acetate (Standard)
    2 Publications Verification

    Reference Standards Progesterone Receptor Autophagy HIV Endocrinology Cancer
    Megestrol acetate (Standard) is the analytical standard of Megestrol acetate. This product is intended for research and analytical applications. Megestrol acetate is a synthetic and orally active progesteronal agent. Megestrol acetate is effective as an appetite stimulant for wasting syndromes such as cachexia. Megestrol acetate decreases nuclear and cytosol androgen receptors human BPH tissue. Megestrol acetate has the potential for HIV study and downregulates autophagic catabolic pathway .
    Megestrol acetate (Standard)
  • HY-W111581
    Copper(II) diethyldithiocarbamate
    1 Publications Verification

    Diethyldithiocarbamic acid copper salt

    Apoptosis Caspase Cancer
    Copper(II) diethyldithiocarbamate (Diethyldithiocarbamic acid copper salt) is a Copper(II) and diethyldithiocarbamate coordination polymer. Copper(II) diethyldithiocarbamate binds tightly to NPL4 and induces its aggregation, disrupting the p97-NPL4-UFD1 pathway. Copper(II) diethyldithiocarbamate causes ubiquitinated proteins accumulation and impairs waste proteins degradation, thus resulting in cell apoptosis. Copper(II) diethyldithiocarbamate inhibits tumor growth in MDA-MB-231 xenograft mice models. Copper(II) diethyldithiocarbamate can be used for the research of cancer, such as breast cancer .
    Copper(II) diethyldithiocarbamate
  • HY-W184800

    Bacterial E1/E2/E3 Enzyme Inflammation/Immunology
    MuRF1-IN-2 (Example 3) is a MuRF1 inhibitor. MuRF1-IN-2 can be used for research of muscle wasting conditions, of skeletal or cardial muscle atrophy .
    MuRF1-IN-2
  • HY-Y1219E

    Biochemical Assay Reagents Others
    Silica gel, high-purity grade, 130-270 mesh is a low-density, high-surface-area, high-purity inert additive that can be used to prepare chromatographic column sieve plates based on the sol-gel method. Silica gel, high-purity grade prevents DNA degradation by absorbing water from plant leaves, and is suitable for the preservation of field-collected samples for subsequent DNA extraction, restriction endonuclease digestion, PCR amplification and gene sequencing. It can also be reused after being saturated with water. Silica gel, high-purity grade can provide a non-toxic, inert aquatic environment for embedded cells, allowing nutrients, oxygen and metabolic waste to diffuse freely and blocking external pollution, thereby maintaining the activity of fibroblasts and epithelial cells .
    Silica gel, high-purity grade, 130-270 mesh
  • HY-W009048

    DCH18C6; Perhydrodibenzo-18-crown-6

    Biochemical Assay Reagents Others
    Dicyclohexano-18-crown-6-ether (DCH18C6) is an excellent strontium chelating agent. Dicyclohexano-18-crown-6-ether exhibits favorable extraction capacity and selectivity toward Sr (II). After chemical modification, Dicyclohexano-18-crown-6-ether is covalently bonded to an organosilicon matrix via co-condensation. DCH18C6-functionalized organosilicon materials are expected to be applied to the extraction and separation of strontium from radioactive waste liquid .
    Dicyclohexano-18-crown-6-ether
  • HY-Y1219I

    Biochemical Assay Reagents Others
    Silica gel, high-purity grade, 70-230 mesh is a low-density, high-surface-area, high-purity inert additive that can be used to prepare chromatographic column sieve plates based on the sol-gel method. Silica gel, high-purity grade prevents DNA degradation by absorbing water from plant leaves, and is suitable for the preservation of field-collected samples for subsequent DNA extraction, restriction endonuclease digestion, PCR amplification and gene sequencing. It can also be reused after being saturated with water. Silica gel, high-purity grade can provide a non-toxic, inert aquatic environment for embedded cells, allowing nutrients, oxygen and metabolic waste to diffuse freely and blocking external pollution, thereby maintaining the activity of fibroblasts and epithelial cells .
    Silica gel, high-purity grade, 70-230 mesh
  • HY-Y1219D

    Biochemical Assay Reagents Others
    Silica gel, high-purity grade, 35-70 mesh is a low-density, high-surface-area, high-purity inert additive that can be used to prepare chromatographic column sieve plates based on the sol-gel method. Silica gel, high-purity grade prevents DNA degradation by absorbing water from plant leaves, and is suitable for the preservation of field-collected samples for subsequent DNA extraction, restriction endonuclease digestion, PCR amplification and gene sequencing. It can also be reused after being saturated with water. Silica gel, high-purity grade can provide a non-toxic, inert aquatic environment for embedded cells, allowing nutrients, oxygen and metabolic waste to diffuse freely and blocking external pollution, thereby maintaining the activity of fibroblasts and epithelial cells .
    Silica gel, high-purity grade, 35-70 mesh
  • HY-Y1219C

    Biochemical Assay Reagents Others
    Silica gel, high-purity grade, 220-440 mesh is a low-density, high-surface-area, high-purity inert additive that can be used to prepare chromatographic column sieve plates based on the sol-gel method. Silica gel, high-purity grade prevents DNA degradation by absorbing water from plant leaves, and is suitable for the preservation of field-collected samples for subsequent DNA extraction, restriction endonuclease digestion, PCR amplification and gene sequencing. It can also be reused after being saturated with water. Silica gel, high-purity grade can provide a non-toxic, inert aquatic environment for embedded cells, allowing nutrients, oxygen and metabolic waste to diffuse freely and blocking external pollution, thereby maintaining the activity of fibroblasts and epithelial cells .
    Silica gel, high-purity grade, 220-440 mesh
  • HY-123012A

    LY-591281; LY-488756 fumarate

    Androgen Receptor Others
    Lubabegron fumarate is a potent modulator of β-adrenergic receptor (β-AR). Lubabegron fumarate demonstrates antagonistic behavior at the β1 and β 2 receptor subtypes and agonistic behavior at the β 3 receptor subtype in cattle. Lubabegron fumarate reduces NH3 gas emissions from an animal or its waste. Lubabegron fumarate is available as an animal supplement .
    Lubabegron fumarate
  • HY-105318

    Androgen Receptor Metabolic Disease Endocrinology
    LGD-2226 is a selective and orally active androgen receptor modulator with an EC50 of 0.2 nM and a Ki of 1.5 nM for human androgen receptor. LGD-2226 shows tissue selectivity in animal models, with reduced effects on prostate compared to muscle. LGD-2226 can be used for muscle wasting, osteoporosis and sexual dysfunction .
    LGD-2226
  • HY-N0701C

    Others Others
    DL-Asarinin (compound 88) is a natural product that can be found in waste leaves of Cinnamomum camphora .
    DL-Asarinin
  • HY-P2815

    Biochemical Assay Reagents Others
    Creatinine deiminase is a hydrolytic enzyme. Creatinine deiminase plays a crucial role in the conversion of the metabolic waste creatinine into creatine. Creatinine deiminase is a creatine bioanalytical tool. Creatinine deiminase can be used to construct a novel creatinine-sensitive biosensor when adsorbed on a silicate-modified pH-sensitive field-effect transistor (pH-FET) .
    Creatinine deiminase
  • HY-13676S

    Isotope-Labeled Compounds Progesterone Receptor Autophagy HIV Endocrinology Cancer
    Megestrol acetate-d3 is the deuterium labeled Megestrol acetate. Megestrol acetate is a synthetic and orally active progesteronal agent. Megestrol acetate is effective as an appetite stimulant for wasting syndromes such as cachexia. Megestrol acetate decreases nuclear and cytosol androgen receptors human BPH tissue. Megestrol acetate has the potential for HIV study and downregulates autophagic catabolic pathway .
    Megestrol acetate-d3
  • HY-W111881

    Biochemical Assay Reagents Others
    Furfurylideneacetone is a furfural-acetone compound and can be used as active diluent for epoxy resins fabrication .
    Furfurylideneacetone
  • HY-111246

    Androgen Receptor Cancer
    MK-3984 is a selective androgen receptor modulator (SARM). MK-3984 can be used for the research of muscle wasting associated with cancer .
    MK-3984
  • HY-W077917

    Others Others
    6-Chlorovanillin is identified in waste waters from bleached kraft pulp mills in Ontario and earlier also elsewhere >[1].
    6-Chlorovanillin
  • HY-111044

    Androgen Receptor Cancer
    (+)-JNJ-37654032 is an orally active and selective androgen receptor modulator. (+)-JNJ-37654032 can be used in the study of muscle-wasting diseases .
    (+)-JNJ-37654032
  • HY-160240

    Fluorescent Dye Others Cancer
    HPI is a HS - fluorescent probe (Ex/Em=280/410 nm). HPI can be used to detect the HS - form of hydrogen sulfide (H2S) gas in environmental water samples .
    HPI
  • HY-13676S1

    Isotope-Labeled Compounds Progesterone Receptor Autophagy HIV Endocrinology Cancer
    Megestrol acetate-d3-1 is deuterium labeled Megestrol acetate. Megestrol acetate is a synthetic and orally active progesteronal agent. Megestrol acetate is effective as an appetite stimulant for wasting syndromes such as cachexia. Megestrol acetate decreases nuclear and cytosol androgen receptors human BPH tissue. Megestrol acetate has the potential for HIV study and downregulates autophagic catabolic pathway .
    Megestrol acetate-d3-1
  • HY-W1006349

    1,2,3,4,6,7,8-HpCDF

    Drug Metabolite Others
    1,2,3,4,6,7,8-Heptachlorodibenzofuran (1,2,3,4,6,7,8-HpCDF) is a dioxin-like polychlorinated dibenzofuran (PCDF). 1,2,3,4,6,7,8-Heptachlorodibenzofuran has been found in the soil near municipal waste incinerators, in freshwater fish, and in human breastmilk .
    1,2,3,4,6,7,8-Heptachlorodibenzofuran
  • HY-105318R

    Reference Standards Androgen Receptor Metabolic Disease Endocrinology
    LGD-2226 (Standard) is the analytical standard of LGD-2226 (HY-105318). This product is intended for research and analytical applications. LGD-2226 is a selective and orally active androgen receptor modulator with an EC50 of 0.2 nM and a Ki of 1.5 nM for human androgen receptor. LGD-2226 shows tissue selectivity in animal models, with reduced effects on prostate compared to muscle. LGD-2226 can be used for muscle wasting, osteoporosis and sexual dysfunction .
    LGD-2226 (Standard)
  • HY-182773

    Melanocortin Receptor Metabolic Disease
    MC4R Antagonist-1 (compound 1) is an MC4R-selective antagonist (IC50<10 nM). MC4R Antagonist-1 can be used for the research of cachexia, anorexia, anorexia nervosa, involuntary weight loss, failure to thrive, sarcopenia, muscle wasting, muscle weakness, frailty, osteoporosis .
    MC4R Antagonist-1
  • HY-N12385

    (R)-Hispaglabridin B

    FOXO Others
    Hispaglabridin B is an anti-oxidant agent that can be isolated from Glycyrrhiza glabra. Hispaglabridin B exhibits potent peroxynitrite scavenging activity with an IC50 of 3.2 μM, and shows activity in a low-density lipoprotein (LDL) oxidation system . Hispaglabridin B is also a FoxO1 inhibitor . Hispaglabridin B improves muscle wasting by inhibiting catabolism in vivo and in vitro.
    Hispaglabridin B
  • HY-W111403

    Environmental Pollutants Biochemical Assay Reagents Others
    Calcium oxide (CaO) acts as a heterogeneous base catalyst. Calcium oxide can be extracted not only from waste materials such as oyster shells, eggshells and crab shells, but also exhibits tolerance to low to moderate oil quality, free fatty acid and water content in raw materials. Calcium oxide can be used in biodiesel production, where it effectively catalyzes the transesterification of vegetable oils or animal fats to produce alkyl esters .
    Calcium oxide
  • HY-N18676

    Others Metabolic Disease
    Dolichos Biflorus Extract, derived from the seeds of the Dolichos biflorus plant (commonly known as horse gram), is a nutrient-dense herb widely used in Ayurvedic and traditional medicine for its numerous health benefits. Dolichos biflorus extract contains alkaloids, saponins, flavonoids, carbohydrates, proteins, and tannins. It is known for its digestive support, as it promotes healthy digestion, alleviates bloating, and helps with constipation, along with mild diuretic effects that aid detoxification by eliminating excess fluids and waste products from the body.
    Dolichos biflorus extract

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