13681-87-3
Chemical Structure
Copper(II) diethyldithiocarbamate
Synonym(s): Diethyldithiocarbamic acid copper salt
- CAS No.: 13681-87-3
- Formula:C10H20CuN2S4
- Molecular Weight:360.09
InChIKey: OBBCYCYCTJQCCK-UHFFFAOYSA-L
SMILES: CCN(CC)C([S-]1)=[S][Cu+2]21[S-]C(N(CC)CC)=[S]2
Biological Activity: Copper(II) diethyldithiocarbamate (Diethyldithiocarbamic acid copper salt) is a Copper(II) and diethyldithiocarbamate coordination polymer. Copper(II) diethyldithiocarbamate binds tightly to NPL4 and induces its aggregation, disrupting the p97-NPL4-UFD1 pathway. Copper(II) diethyldithiocarbamate causes ubiquitinated proteins accumulation and impairs waste proteins degradation, thus resulting in cell apoptosis. Copper(II) diethyldithiocarbamate inhibits tumor growth in MDA-MB-231 xenograft mice models. Copper(II) diethyldithiocarbamate can be used for the research of cancer, such as breast cancer[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Copper(II) diethyldithiocarbamate | 98.5% | Copper(II) diethyldithiocarbamate (Diethyldithiocarbamic acid copper salt) is a Copper(II) and diethyldithiocarbamate coordination polymer. Copper(II) diethyldithiocarbamate binds tightly to NPL4 and induces its aggregation, disrupting the p97-NPL4-UFD1 pathway. Copper(II) diethyldithiocarbamate causes ubiquitinated proteins accumulation and impairs waste proteins degradation, thus resulting in cell apoptosis. Copper(II) diethyldithiocarbamate inhibits tumor growth in MDA-MB-231 xenograft mice models. Copper(II) diethyldithiocarbamate can be used for the research of cancer, such as breast cancer. | ||||||||||||||||||||
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- [1]. Peng Y, et al. Nanoscale Copper(II)-Diethyldithiocarbamate Coordination Polymer as a Drug Self-Delivery System for Highly Robust and Specific Cancer Therapy. Mol Pharm. 2020;17(8):2864-2873. [Content Brief]
- [2]. Wang L, et al. A facile synthesis of Cu (II) diethyldithiocarbamate from monovalent copper-cysteamine and disulfiram[J]. Inorganic Chemistry Communications, 2022, 137: 109246.
Keywords
