Copper(II) diethyldithiocarbamate
Based on 1 publication(s) in Google Scholar
Copper(II) diethyldithiocarbamate (Diethyldithiocarbamic acid copper salt) is a Copper(II) and diethyldithiocarbamate coordination polymer. Copper(II) diethyldithiocarbamate binds tightly to NPL4 and induces its aggregation, disrupting the p97-NPL4-UFD1 pathway. Copper(II) diethyldithiocarbamate causes ubiquitinated proteins accumulation and impairs waste proteins degradation, thus resulting in cell apoptosis. Copper(II) diethyldithiocarbamate inhibits tumor growth in MDA-MB-231 xenograft mice models. Copper(II) diethyldithiocarbamate can be used for the research of cancer, such as breast cancer.
For research use only. We do not sell to patients.
- Purity: 98.5%
- CAS No.: 13681-87-3
- Formula: C10H20CuN2S4
- Molecular Weight:360.09
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Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Copper(II) diethyldithiocarbamate
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Biological Activity
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Caspase 3 |
Copper(II) diethyldithiocarbamate (Compound CuET) (16-4000 nM; 48 h) delivered via CuET NPs and CuET@HA NPs is more cytotoxic to MDA-MB-231 breast cancer cells (IC50 115 nM and 97 nM, respectively) than to normal HEK-293 kidney cells (IC50 389 nM and 407.4 nM, respectively)[1].
Copper(II) diethyldithiocarbamate (0.1-1.0 μM; 24 h) delivered via CuET NPs induces concentration-dependent accumulation of poly-ubiquitylated proteins in MDA-MB-231 cells, confirming inhibition of the p97-NPL4 pathway[1].
Copper(II) diethyldithiocarbamate (0.5-5 μM; 24 h) delivered via CuET NPs and CuET@HA NPs induces concentration-dependent cell death in MDA-MB-231 cells after 24 h of incubation[1].
Copper(II) diethyldithiocarbamate (100-200 nM; 48 h) delivered via CuET NPs and CuET@HA NPs significantly inhibits colony formation in MDA-MB-231 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231 (triple negative breast cancer) cells, HEK-293 (human embryo kidney) cells
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Concentration:16, 32, 64, 125, 250, 500, 1000, 2000, 4000 nM (equivalent diethyldithiocarbamate concentration)
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Incubation Time:48 h
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Result:Showed concentration-dependent cytotoxicity in MDA-MB-231 cells, with CuET@HA NPs exhibiting higher activity at each concentration.
Reached an IC50 of 115 nM in MDA-MB-231 cells (CuET NPs).
Reached an IC50 of 97 nM in MDA-MB-231 cells (CuET@HA NPs).
Reached an IC50 of 389 nM in HEK-293 cells (CuET NPs).
Reached an IC50 of 407.4 nM in HEK-293 cells (CuET@HA NPs).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c nude with MDA-MB-231 xenograft (female, 6 weeks old)[1]
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Dosage:1 mg/kg (equivalent diethyldithiocarbamate dose)
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Administration:i.v.
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Result:Inhibited tumor growth significantly over 14 days, with CuET@HA NPs showing the most potent efficacy (slowest tumor growth rate and smallest final tumor size).
Induced the most distinct nuclear necrosis in tumor tissue on H&E staining (CuET@HA NP-treated mice).
Increased caspase-3 activation to the highest level on immunofluorescence staining (CuET@HA NP-treated mice).
Caused the greatest extent of apoptosis on TUNEL staining (CuET@HA NP-treated mice).
Caused no noticeable mouse weight loss or pathological changes in major organs (heart, liver, spleen, lung, kidney) during treatment.
Chemical Information
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CAS No. 13681-87-3
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Appearance Solid
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Molecular Weight 360.09
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Formula C10H20CuN2S4
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Color Brown to black
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SMILES
CCN(CC)C([S-]1)=[S][Cu+2]21[S-]C(N(CC)CC)=[S]2
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Synonyms
Diethyldithiocarbamic acid copper salt
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Publications (1)
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Journal Impact Factor
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Most Recent
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Discov Oncol
Identification of key genes participating in copper-diethyldithiocarbamate-related cell death process and predicting the development of prostate cancer. [Abstract]2024 Oct 3;15(1):519. PMID: 39361158
Solvent & Solubility
DMSO : 2 mg/mL (5.55 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (282 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7771 mL | 13.8854 mL | 27.7708 mL | 69.4271 mL |
| 5 mM | 0.5554 mL | 2.7771 mL | 5.5542 mL | 13.8854 mL |
Copper(II) diethyldithiocarbamate Related Classifications
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