SA09-Cu
SA09-Cu is a noncompetitive and potent NDM-1 inhibitor with an IC50 of 9.6 nM. SA09-Cu can convert NDM-1 into an inactive state by oxidizing the Zn(II)-thiolate site of the enzyme and avoids to be reduced by intracellular thiols of bacteria. SA09-Cu exhibits excellent inhibition against a series of clinical NDM-1-producing carbapenem-resistant Enterobacteriaceae (CRE) in restoring the Meropenem (HY-13678) effect, and slows down the development of carbapenem resistance.
For research use only. We do not sell to patients.
- CAS No.: 155641-16-0
- Formula: C8H16CuN2O2S4
- Molecular Weight:364.03
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
IC50: 9.6 nM (NDM-1)[1]
In Vitro
SA09-Cu (5-160 μg/mL; 24 h) causes the survival rate of Vero E6 and L929 mouse cells higher than 60% with 40 µg/mL[1].
SA09-Cu (2, 4, 8, 16 μg/mL; 24 h) shows the obvious inhibition of NDM-1 activity in living cells (E. coli-BL21-NDM-1 and EC23) with concentration gradually increasing[1].
SA09-Cu itself demonstrates no or minor antibacterial activity (MIC≥64 μg/mL)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 155641-16-0
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Molecular Weight 364.03
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Formula C8H16CuN2O2S4
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SMILES
OCCN(C)C1=[S-][Cu+2]2(SC(N(C)CCO)=[S-]2)S1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SA09-Cu Related Classifications
HY-150260 Related Classifications
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