1. Anti-infection
  2. Bacterial
  3. SA09-Cu

SA09-Cu is a noncompetitive and potent NDM-1 inhibitor with an IC50 of 9.6 nM. SA09-Cu can convert NDM-1 into an inactive state by oxidizing the Zn(II)-thiolate site of the enzyme and avoids to be reduced by intracellular thiols of bacteria. SA09-Cu exhibits excellent inhibition against a series of clinical NDM-1-producing carbapenem-resistant Enterobacteriaceae (CRE) in restoring the Meropenem (HY-13678) effect, and slows down the development of carbapenem resistance.

For research use only. We do not sell to patients.

SA09-Cu Chemical Structure

SA09-Cu Chemical Structure

CAS No. : 155641-16-0

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Description

SA09-Cu is a noncompetitive and potent NDM-1 inhibitor with an IC50 of 9.6 nM. SA09-Cu can convert NDM-1 into an inactive state by oxidizing the Zn(II)-thiolate site of the enzyme and avoids to be reduced by intracellular thiols of bacteria. SA09-Cu exhibits excellent inhibition against a series of clinical NDM-1-producing carbapenem-resistant Enterobacteriaceae (CRE) in restoring the Meropenem (HY-13678) effect, and slows down the development of carbapenem resistance[1].

IC50 & Target

IC50: 9.6 nM (NDM-1)[1]

In Vitro

SA09-Cu (5-160 μg/mL; 24 h) causes the survival rate of Vero E6 and L929 mouse cells higher than 60% with 40 µg/mL[1].
SA09-Cu (2, 4, 8, 16 μg/mL; 24 h) shows the obvious inhibition of NDM-1 activity in living cells (E. coli-BL21-NDM-1 and EC23) with concentration gradually increasing[1].
SA09-Cu itself demonstrates no or minor antibacterial activity (MIC≥64 μg/mL)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

364.03

Formula

C8H16CuN2O2S4

CAS No.
SMILES

OCCN(C)C1=[S-][Cu+2]2(SC(N(C)CCO)=[S-]2)S1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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SA09-Cu Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
SA09-Cu
Cat. No.:
HY-150260
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