155641-16-0
Chemical Structure
SA09-Cu
- CAS No.: 155641-16-0
- Formula:C8H16CuN2O2S4
- Molecular Weight:364.03
InChIKey: BGJFLLXGJLWYFI-UHFFFAOYSA-L
SMILES: OCCN(C)C1=[S-][Cu+2]2(SC(N(C)CCO)=[S-]2)S1
Biological Activity: SA09-Cu is a noncompetitive and potent NDM-1 inhibitor with an IC50 of 9.6 nM. SA09-Cu can convert NDM-1 into an inactive state by oxidizing the Zn(II)-thiolate site of the enzyme and avoids to be reduced by intracellular thiols of bacteria. SA09-Cu exhibits excellent inhibition against a series of clinical NDM-1-producing carbapenem-resistant Enterobacteriaceae (CRE) in restoring the Meropenem (HY-13678) effect, and slows down the development of carbapenem resistance[1].
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SA09-Cu | SA09-Cu is a noncompetitive and potent NDM-1 inhibitor with an IC50 of 9.6 nM. SA09-Cu can convert NDM-1 into an inactive state by oxidizing the Zn(II)-thiolate site of the enzyme and avoids to be reduced by intracellular thiols of bacteria. SA09-Cu exhibits excellent inhibition against a series of clinical NDM-1-producing carbapenem-resistant Enterobacteriaceae (CRE) in restoring the Meropenem (HY-13678) effect, and slows down the development of carbapenem resistance. | |||||||||||||||||||||
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Keywords
