Landogrozumab
Based on 1 publication(s) in Google Scholar
Landogrozumab (LY2495655) is an humanized anti-myostatin monoclonal antibody. Landogrozumab effectively improves muscle volume, hand grip strength and function. Landogrozumab can be used for the research of muscle wasting disease.
For research use only. We do not sell to patients.
- Purity: 99.79%
- CAS No.: 1391726-30-9
- Molecular Weight:146.4 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) Landogrozumab
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Biological Activity
Description
Isotype
Human IgG4 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
GDF8/Myostatin
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Duchenne muscular dystrophy (DMD) C57BL/10-mdx mouse model[1]
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Dosage:3 and 50 mg/kg
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Administration:Intravenous injection; 3 and 50 mg/kg once
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Result:Increasesd muscle mass of aged mice at a dose of 50 mg/kg while 3 mg/kg showed no significant effects.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Human IgG4 kappa
Application
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized GDF-8 Protein, Human/Mouse/Rat (HEK293, HY-P72632) can bind Landogrozumab. The EC50 for this effect is 1.187 ng/mL. -
Flow cytometric analysis of 1X106 HeLa cells with Landogrozumab (HY-P99370, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control.
Chemical Information
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CAS No. 1391726-30-9
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Appearance Liquid
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Molecular Weight 146.4 kDa
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Color Colorless to light yellow
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SMILES
[Landogrozumab]
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Synonyms
LY2495655; Anti-GDF8 / Myostatin Reference Antibody (landogrozumab)
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Sci Rep
Combined detection of inhibitors of the activin receptor signaling pathways (IASPs) by means of LC-HRMS/MS for human doping control. [Abstract]2025 Jun 6;15(1):19887. PMID: 40481031
Purity & Documentation
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Data Sheet (259 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)