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Cat. No.: HY-N15497

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Terpestacin

Name: Terpestacin
Brand: MedChemExpress
SKU: HY-N15497
Price: 760.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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Based on 1 Customer Validation

Terpestacin is found in Phoma exigua var. heteromorpha. Terpestacin binds to UQCRB to inhibit the production of mitochondrial ROS and HIF-1α. Terpestacin inhibits tumor angiogenesis in the FM3A breast cancer cell xenograft mouse model. Terpestacin has antitumor activity and phytotoxicity.

For research use only. We do not sell to patients.

Purity: 99.9%
CAS No.: 146436-22-8
Formula: C₂₅H₃₈O₄
Molecular Weight:402.57

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Terpestacin Chemical Structure

CAS No.: 146436-22-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All HIF/HIF Prolyl-Hydroxylase Isoforms :

Chemical Information

CAS No. 146436-22-8
Appearance Solid
Molecular Weight 402.57
Formula C₂₅H₃₈O₄
Color White to off-white
SMILES

OC[C@@H](C)C1=C(C([C@@]2([C@@]1(C/C=C([C@H](CC/C(C)=C/CC/C(C)=C/C2)O)\C)[H])C)=O)O
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
- Animals
Phoma exigua var. heteromorpha
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Masi M, et al. Terpestacin, a toxin produced by Phoma exigua var. heteromorpha, the causal agent of a severe foliar disease of oleander (Nerium oleander L.). Nat Prod Res. 2022 Mar;36(5):1253-1259. [Content Brief]

[2]. Jung HJ, et al. Terpestacin inhibits tumor angiogenesis by targeting UQCRB of mitochondrial complex III and suppressing hypoxia-induced reactive oxygen species production and cellular oxygen sensing. J Biol Chem. 2010 Apr 9;285(15):11584-95. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Terpestacin

All HIF/HIF Prolyl-Hydroxylase Isoforms