Sodium bromide (Synonyms: NSC 77384; Sanibrom 40)

Name: Sodium bromide
Brand: MedChemExpress
SKU: HY-Y0282
Rating: 4.5 (1 reviews)

Cat. No.: HY-Y0282 Purity: 100.7%: Data Sheet
COA

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Sodium bromide (NSC 77384; Sanibrom 40) is a GABA-ergic system modulator that crosses the blood-brain barrier, and it effectively reduces and blocks epileptiform discharges. Sodium bromide exerts significant anticonvulsant effects by enhancing GABA-ergic inhibitory functions, such as increasing the amplitude of inhibitory postsynaptic currents and paired-pulse inhibition. Sodium bromide specifically enhances stimulation-induced extracellular alkalosis without affecting baseline pH or subsequent acidosis processes. Sodium bromide exhibits species-specific pharmacokinetic characteristics, competes with chloride ions for renal tubular reabsorption sites, and serves as a marker for extracellular fluid volume. Sodium bromide can be used in the research of epilepsy and related neurological diseases.

For research use only. We do not sell to patients.

Sodium bromide Chemical Structure

CAS No. : 7647-15-6

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
100 g	In-stock	Estimated Time of Arrival: December 31
500 g	In-stock	Estimated Time of Arrival: December 31
1 kg	In-stock	Estimated Time of Arrival: December 31

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Based on 1 publication(s) in Google Scholar

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Description

In Vitro

Sodium bromide (1-11 mM; ≥15-20 min) concentration-dependently reduces and blocks low-Ca²⁺-induced epileptiform discharges in rat hippocampal area CA1, with complete block at 11 mM^[1].
Sodium bromide (3-20 mM; ≥15-20 min) concentration-dependently reduces and blocks low-Mg²⁺-induced short recurrent discharges in rat hippocampal areas CA1 and CA3, with complete block at 20 mM^[1].
Sodium bromide (1-7 mM; ≥15-20 min) concentration-dependently reduces and blocks low-Mg²⁺-induced seizure-like events in rat medial entorhinal cortex, with complete block at 7 mM^[1].
Sodium bromide (1-30 mM; ≥15-20 min) concentration-dependently reduces and blocks low-Mg²⁺-induced late recurrent discharges in rat medial entorhinal cortex, with complete block at 30 mM^[1].
Sodium bromide (1-5 mM; ≥15-20 min) at 5 mM enhances paired-pulse inhibition in rat hippocampal area CA1, indicating increased GABAergic inhibition^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Sodium bromide (30 mg/kg; i.v.; single dose) administered to healthy mixed-breed mares produces a stable serum bromide concentration by 5 hours, allowing accurate estimation of ECFV via corrected bromide space (mean 0.218 L/kg), while also causing a transient, statistically significant decrease in PCV that resolves by 20 hours post-administration^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	mixed-breed mares (15-21 years of age)^[2]
Dosage:	30 mg/kg
Administration:	i.v.; single dose (administered over 3 minutes)
Result:	Achieved a maximum mean serum bromide concentration of 115.4 μg/mL, with concentrations stabilizing by 5 hours post-administration. Reached a mean corrected bromide space of 0.218 L/kg (steady-state volume of distribution) and 0.216 L/kg (5-hour serum bromide concentration), with no significant difference between values. Induced a statistically significant increase in measured serum chloride concentration at 1 hour (96.8 mmol/L to 97.8 mmol/L, P = .012) and 6 hours (96.8 mmol/L to 98.0 mmol/L, P = .034) post-administration, a pseudohyperchloremia. Showed no significant changes in serum sodium, potassium, or total CO₂ concentrations, or in plasma total protein concentrations.

Clinical Trial

Molecular Weight

102.89

Formula

BrNa

CAS No.

7647-15-6

Appearance

Solid

Color

White to off-white

SMILES

[Na]Br

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature, keep dry and cool

In solvent	-80°C	1 year
	-20°C	6 months

Solvent & Solubility

In Vitro:

H₂O : ≥ 100 mg/mL (971.91 mM)

DMSO : 33.33 mg/mL (323.94 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	9.7191 mL	48.5956 mL	97.1912 mL
5 mM	1.9438 mL	9.7191 mL	19.4382 mL
10 mM	0.9719 mL	4.8596 mL	9.7191 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 3.33 mg/mL (32.36 mM); Clear solution

This protocol yields a clear solution of ≥ 3.33 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (33.3 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 3.33 mg/mL (32.36 mM); Clear solution

This protocol yields a clear solution of ≥ 3.33 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (33.3 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 3.33 mg/mL (32.36 mM); Clear solution

This protocol yields a clear solution of ≥ 3.33 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (33.3 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 100.7%

Select Batch:

Data Sheet (277 KB) SDS (557 KB)

COA (312 KB)

Handling Instructions (2659 KB)

References

[1]. Meierkord H, et al. Sodium bromide: effects on different patterns of epileptiform activity, extracellular pH changes and GABAergic inhibition. Naunyn Schmiedebergs Arch Pharmacol. 2000;361(1):25-32. [Content Brief]

[2]. Fielding CL, et al. Pharmacokinetics and clinical utility of sodium bromide (NaBr) as an estimator of extracellular fluid volume in horses. J Vet Intern Med. 2003;17(2):213-217. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	9.7191 mL	48.5956 mL	97.1912 mL	242.9779 mL
	5 mM	1.9438 mL	9.7191 mL	19.4382 mL	48.5956 mL
	10 mM	0.9719 mL	4.8596 mL	9.7191 mL	24.2978 mL
	15 mM	0.6479 mL	3.2397 mL	6.4794 mL	16.1985 mL
	20 mM	0.4860 mL	2.4298 mL	4.8596 mL	12.1489 mL
	25 mM	0.3888 mL	1.9438 mL	3.8876 mL	9.7191 mL
	30 mM	0.3240 mL	1.6199 mL	3.2397 mL	8.0993 mL
	40 mM	0.2430 mL	1.2149 mL	2.4298 mL	6.0744 mL
	50 mM	0.1944 mL	0.9719 mL	1.9438 mL	4.8596 mL
	60 mM	0.1620 mL	0.8099 mL	1.6199 mL	4.0496 mL
	80 mM	0.1215 mL	0.6074 mL	1.2149 mL	3.0372 mL
	100 mM	0.0972 mL	0.4860 mL	0.9719 mL	2.4298 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Sodium bromide Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Sodium bromide (Synonyms: NSC 77384; Sanibrom 40)

Customer Review

Sodium bromide Related Antibodies

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Complete Stock Solution Preparation Table

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