1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. Tipepidine hydrochloride

Tipepidine hydrochloride 

Cat. No.: HY-121685A
Handling Instructions

Tipepidine hydrochloride reversibly inhibits dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) with an IC50 of 7.0 μM. Tipepidine hydrochloride subsequently activates VTA dopamine neuron. Tipepidine hydrochloride, a non-narcotic antitussive, exerts an antidepressant-like effect.

For research use only. We do not sell to patients.

Tipepidine hydrochloride Chemical Structure

Tipepidine hydrochloride Chemical Structure

CAS No. : 1449686-84-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 385 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Tipepidine hydrochloride reversibly inhibits dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) with an IC50 of 7.0 μM. Tipepidine hydrochloride subsequently activates VTA dopamine neuron[1]. Tipepidine hydrochloride, a non-narcotic antitussive, exerts an antidepressant-like effect[2].

IC50 & Target

IC50: 7.0 μM (dopamine D2 receptor)[1]

In Vivo

Tipepidine (i.p.; 10-40 mg/kg; 0.5-23 hours) significantly decreases the immobility time in the forced swimming test in ACTH-treated rats. Tipepidine (i.p.; 40 mg/kg) increases the extracellular dopamine level of the nucleus accumbens (NAc) in ACTH-treated rats[2].

Animal Model: Male Wistar rats weighting 150-240 g (5-7 weeks old) [2]
Dosage: 10, 20 and 40 mg/kg
Administration: I.p.; 0.5, 5, 23 hours
Result: Decreased the immobility time in the forced swimming test in ACTH-treated rats.
Molecular Weight

311.89

Formula

C₁₅H₁₈ClNS₂

CAS No.

1449686-84-3

SMILES

CN1C/C(CCC1)=C(C2=CC=CS2)\C3=CC=CS3.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 41.67 mg/mL (133.60 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2063 mL 16.0313 mL 32.0626 mL
5 mM 0.6413 mL 3.2063 mL 6.4125 mL
10 mM 0.3206 mL 1.6031 mL 3.2063 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.67 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (6.67 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.67 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

TipepidinePotassium ChannelKcsAInhibitorinhibitorinhibit

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Product name:
Tipepidine hydrochloride
Cat. No.:
HY-121685A
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