1449686-84-3
1449686-84-3
Chemical Structure
Tipepidine hydrochloride
- CAS No.: 1449686-84-3
- Formula:C15H18ClNS2
- Molecular Weight:311.89
IUPAC Name: 3-(di(thiophen-2-yl)methylene)-1-methylpiperidine hydrochloride
InChIKey: MICLPSFJJVIDJE-UHFFFAOYSA-N
SMILES: CN1C/C(CCC1)=C(C2=CC=CS2)\C3=CC=CS3.[H]Cl
Biological Activity: Tipepidine hydrochloride reversibly inhibits dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) with an IC50 of 7.0 μM. Tipepidine hydrochloride subsequently activates VTA dopamine neuron[1]. Tipepidine hydrochloride, a non-narcotic antitussive, exerts an antidepressant-like effect[2].
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Tipepidine hydrochloride | 99.98% | Tipepidine hydrochloride reversibly inhibits dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) with an IC50 of 7.0 μM. Tipepidine hydrochloride subsequently activates VTA dopamine neuron. Tipepidine hydrochloride, a non-narcotic antitussive, exerts an antidepressant-like effect. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.98
HY-121685Tipepidine -
Similarity Score 0.74
HY-W725190Piperidylthiambutene hydrochloride -
Similarity Score 0.73
HY-U00184Timepidium bromide -
Similarity Score 0.73
HY-W725190APiperidylthiambutene -
Similarity Score 0.72
HY-B2185Tipepidine citrate -
Similarity Score 0.69
HY-135754Tiquizium bromide -
Similarity Score 0.59
HY-15880CCT007093 -
Similarity Score 0.56
HY-106487Pridefine -
Similarity Score 0.54
HY-B2101Thenalidine -
Explore the MedChemAI to find more analogs
References
- [1]. Hamasaki R, et al. Tipepidine activates VTA dopamine neuron via inhibiting dopamine D₂ receptor-mediated inward rectifying K⁺ current. Neuroscience. 2013 Nov 12;252:24-34. [Content Brief]
- [2]. Kawaura K, et al. Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect in the forced swimming test in adrenocorticotropic hormone-treated rats. Behav Brain Res. 2016 Apr 1;302:269-78. [Content Brief]
