DAO - D-amino acid oxidase Gene

Also Known as DAAO; OXDA; DAMOX

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1610

About DAO

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:108,880,092-108,901,043 (from NCBI)

This gene has 8 transcripts (splice variants), 215 orthologues, 1 paralogue and is associated with 1 phenotype. Biased expression in kidney (RPKM 37.6) and liver (RPKM 29.1).

Summary

This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA Receptor. This gene may play a role in the pathophysiology of schizophrenia. [provided by RefSeq, Jul 2008]

DAO Products (3)

mRNA Protein Name
NM_001413634.1 NP_001400563.1 D-amino-acid oxidase isoform a
NM_001413635.1 NP_001400564.1 D-amino-acid oxidase isoform b
NM_001917.5 NP_001908.3 D-amino-acid oxidase isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables D-amino-acid oxidase activity IDA
IDA: Inferred from direct assay
12364586 GOA
enables D-amino-acid oxidase activity IMP
IMP: Inferred from mutant phenotype
29274788 GOA
enables FAD binding IDA
IDA: Inferred from direct assay
16616139 GOA
enables FAD binding IMP
IMP: Inferred from mutant phenotype
29274788 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
16616139 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12364586 GOA
Biological Process GO Annotation Evidence References Source
involved in D-alanine catabolic process IDA
IDA: Inferred from direct assay
16616139 GOA
involved in D-amino acid catabolic process IDA
IDA: Inferred from direct assay
29274788 GOA
involved in D-serine catabolic process IDA
IDA: Inferred from direct assay
18544534 GOA
involved in D-serine metabolic process IDA
IDA: Inferred from direct assay
21679769 GOA
involved in dopamine biosynthetic process IDA
IDA: Inferred from direct assay
17303072 GOA
involved in proline catabolic process IDA
IDA: Inferred from direct assay
16616139 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
17880399 GOA
located in cytosol IDA
IDA: Inferred from direct assay
18544534 GOA
colocalizes with mitochondrial outer membrane IDA
IDA: Inferred from direct assay
21679769 GOA
located in peroxisomal matrix IDA
IDA: Inferred from direct assay
17684499 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DAO Protein Structure

DAO

DAO: FAD dependent oxidoreductase (3 - 328)

  • 0
  • 100
  • 200
  • 300
  • 347 a.a.
Protein Preferred Names Protein Names

D-amino-acid oxidase

DAO Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DAO P14920 PRKAB2 Homo sapiens O43741
Y2H Prey Pooling
25416956
Intra
DAO P14920 PRKAB2 Homo sapiens O43741
Y2H Array
31515488
Intra
DAO P14920 KLHL42 Homo sapiens Q9P2K6
Anti Tag CoIP
33961781
Intra
DAO P14920 KLHL42 Homo sapiens Q9P2K6
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant DAO Proteins

Cat. No. Product Name Accession Purity
HY-P7898 D-amino-acid oxidase/DAO Protein, Human (His) P14920 (M1-L347) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Amyotrophic Lateral Sclerosis 1

  • Amyotrophic Lateral Sclerosis

  • ALS

  • Lou Gehrig Disease

  • Amyotrophic Lateral Sclerosis Type 1

  • Charcot Disease

  • ALS1

  • Amyotrophic Lateral Sclerosis, Susceptibility To

  • Fals

  • Lou Gehrig'S Disease

  • Mnd

  • Motor Neuron Disease

  • Familial Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis 1, Familial

  • Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

  • Motor Neuron Disease, Bulbar

  • Motor Neurone Disease

  • Amyotrophic Lateral Sclerosis With Dementia

  • Dementia With Amyotrophic Lateral Sclerosis

  • Motor Neuron Disease, Amyotrophic Lateral Sclerosis

  • Sclerosis, Lateral, Amyotrophic

  • Sclerosis, Lateral, Amyotrophic, Type 1

  • Amyotrophic Sclerosis

  • Als - [Amyotrophic Lateral Sclerosis]

  • Wasting Palsy

  • Amyotrophic Paralysis

  • Amyotrophy Lateral Sclerosis

  • Wasting Paralysis

  • Spinal Progressive Amyotrophy

  • Progressive Atrophic Paralysis
Bipolar Disorder

  • Bipolar Depression

  • Manic Disorder

  • Depression, Bipolar

  • Bipolar Disorder Manic Phase

  • Depressive-Manic Psych.

  • Manic Bipolar Affective Disorder

  • Manic Bipolar I Disorder

  • Manic Depression

  • Manic Depressive Disorder

  • Mixed Bipolar Disorder

  • Bipolar Affective Disorder

  • Bipolar Affective Psychosis

  • Bipolar Spectrum Disorder

  • Manic Depressive Illness

  • Depression Bipolar

  • Bipolar Disorder, Mixed

  • Major Affective Disorder

  • Major Affective Disorder 1

  • Major Affective Disorder 2
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Aging
Psychotic Disorder

  • Psychotic Disorders

  • Mental Or Behavioural Disorder

  • Psychotic

  • Mental Disorders
Zellweger Syndrome

  • Cerebrohepatorenal Syndrome

  • Zellweger Leukodystrophy

  • Zs

  • Congenital Iron Overload

  • Chr

  • Zws

  • Severe Pbd-Zsd

  • Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder
Schizoaffective Disorder

  • Schizo-Affective Psychosis

  • Schizo-Affective Type Schizophrenia

  • Schizoaffective Psychosis

  • Schizoaffective Schizophrenia

  • Schizophrenia, Schizo-Affective Type

  • Schizophreniform Psychosis, Affective Type
Schizotypal Personality Disorder

  • Schizotypal Personality
Molybdenum Cofactor Deficiency, Complementation Group B

  • MOCODB

  • Sulfite Oxidase Deficiency Due To Molybdenum Cofactor Deficiency Type B

  • Molybdenum Cofactor Deficiency B

  • Molybdenum Cofactor Deficiency Type B

  • Combined Deficiency Of Sulfite Oxidase, Xanthine Dehydrogenase And Aldehyde Oxidase Type B

  • Mocod Type B

  • Molybdenum Cofactor Deficiency Complementation Group B

  • Deficiency, Molybdenum Cofactor, Complementation Group B
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-B1041 Aminoguanidine hydrochloride ≥98.0% Phase 1

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-117292 DAO-IN-2 Inhibitor 99.95% Unkown
HY-W037417 DAO-IN-1 Inhibitor 97.46% Unkown
HY-15913 DAOS 99.88% Unkown
HY-P2758 Diamine oxidase / Unkown
HY-W027382 SEP-227900 99.44% Unkown
HY-RS03523 DAO Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-173255 DAO-dBET1 Degrader / Unkown
HY-RS00771 AOC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17364 Aoc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18733 Dao Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23818 Aoc1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25220 Dao Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W026426 4,5,6,7-Tetrahydro-1,2-benzoxazole-3-carboxylic acid Inhibitor 98.06% Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris DAO VGNC VGNC:39768
Bos taurus DAO VGNC VGNC:27875
Macaca mulatta DAO VGNC VGNC:71729
Rattus norvegicus DAO RGD RGD:621138
Mus musculus DAO MGD MGI:94859
Felis catus DAO VGNC VGNC:61335
Others DAO NCBI