S1PR3 - sphingosine-1-phosphate receptor 3 Gene

Also Known as EDG3; LPB3; S1P3; EDG-3; C9orf47; C9orf108; bA791O21.3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1903

About S1PR3

Cytogenetic location: 9q22.1 Genomic coordinates (GRCh38): 9:88,990,863-89,005,155 (from NCBI)

This gene has 5 transcripts (splice variants), 194 orthologues and 18 paralogues. Ubiquitous expression in adrenal (RPKM 15.3), esophagus (RPKM 10.2) and 24 other tissues.

Summary

This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function. [provided by RefSeq, Jul 2008]

S1PR3 Products (6)

mRNA	Protein	Name
NR_172883.1
NM_001142413.2
NM_001395848.1	NP_001382777.1	sphingosine 1-phosphate receptor 3
NR_172882.1
NM_005226.4	NP_005217.2	sphingosine 1-phosphate receptor 3
NM_001001938.4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables integrin binding	IPI IPI: Inferred from physical interaction	24851274	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24851274	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of establishment of endothelial barrier	IMP IMP: Inferred from mutant phenotype	24851274	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	24851274	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

S1PR3 Protein Structure

7tm_1

0
100
200
300
378 a.a.

Protein Preferred Names	Protein Names
sphingosine 1-phosphate receptor 3	G protein-coupled receptor, endothelial differentiation gene-3 S1P receptor 3 S1P receptor EDG3 S1P receptor Edg-3 endothelial differentiation G-protein coupled receptor 3 endothelial differentiation, sphingolipid G-protein-coupled receptor, 3 sphingosine 1-phosphate receptor Edg-3 uncharacterized protein C9orf47

S1PR3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	S1PR3	Q99500	ITGB4	Homo sapiens	P16144	Anti Bait CoIP	24851274

Cross: Cross-species interaction Intra: Intraspecies interaction

S1PR3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82614	EDG3 Antibody (YA2359)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Mouth Disease	Mouth Diseases Mouth Disorders
Pulmonary Edema
Dermatitis, Atopic, 7	ATOD7 Dermatitis, Atopic, Susceptibility To, 7 Atopic Dermatitis 7 Dermatitis, Atopic 7
Basal Cell Carcinoma	Basal Cell Cancer Basal Cell Neoplasm Basal Cell Carcinoma Of Skin Malignant Basal Cell Tumor Basal Cell Tumor Epithelioma Basal Cell Malignant Basal Cell Neoplasm Rodent Ulcer Carcinoma Basal Cell Neoplasms, Basal Cell Basal Cell Carcinomas Experimental Organism Basal Cell Carcinoma Nodulo-Ulcerative Basal Cell Carcinoma Basalioma Basal Cell Epithelioma Of Skin Bcc - [Basal Cell Carcinoma] Of Skin Rodent Ulcer Of Skin Rodent Ulcer Of Unspecified Site Basal Cell Epithelioma Of Unspecified Site
Waardenburg Syndrome, Type 2b	Waardenburg Syndrome Type 2b WS2B Waardenburg Syndrome, Type Iib Waardenburg Syndrome Type Iib
Second-Degree Atrioventricular Block	Second-Degree Heart Block Second Degree Atrioventricular Block Second Degree Atrioventricular Heart Block Second Degree Heart Block Incomplete Atrioventricular Block, Second Degree Nos Second-Degree Block, Type 1 And 2 Atrioventricular Block, Type 1 And 2 Second Degree Incomplete Atrioventricular Block Av - [Atrioventricular] Block 2nd

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12355	Siponimod	Agonist	99.95%	Yes
HY-10569	Ponesimod	Agonist	99.78%	Yes
HY-12355A	Siponimod hemifumarate	Agonist	99.64%	Yes

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-119401	CAY10444	Antagonist	98.0%	Unkown
HY-111253	CYM-5478	Agonist	99.90%	Unkown
HY-176533	S1PR5-IN-1	Inhibitor	99.58%	Unkown
HY-NP203	High density lipoprotein (human)	Activator	98.00%	Unkown
HY-113934	L-threo Lysosphingomyelin (d18:1)	Agonist	98.0%	Unkown
HY-108492	TC-SP 14	Agonist	/	Unkown
HY-14402	AMG 369	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	S1PR3	RGD	RGD:1583843
Bos taurus	S1PR3	VGNC	VGNC:34254
Mus musculus	S1PR3	MGD	MGI:1339365
Felis catus	S1PR3	VGNC	VGNC:64847
Canis familiaris	S1PR3	VGNC	VGNC:45837
Others	S1PR3	NCBI