S1PR3 - sphingosine-1-phosphate receptor 3 Gene

Homo sapiens

Also known as EDG3; LPB3; S1P3; EDG-3; C9orf47; C9orf108; bA791O21.3

Gene ID: 1903 | Gene type: protein coding

About S1PR3

Cytogenetic location: 9q22.1 Genomic coordinates (GRCh38): 9:88,990,863-89,005,155 (from NCBI)

This gene has 5 transcripts (splice variants), 194 orthologues and 18 paralogues. Ubiquitous expression in adrenal (RPKM 15.3), esophagus (RPKM 10.2) and 24 other tissues.

Summary

This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function. [provided by RefSeq, Jul 2008]

S1PR3 Products(6)

mRNA	Protein	Name
NR_172883.1
NM_001142413.2
NM_001395848.1	NP_001382777.1	sphingosine 1-phosphate receptor 3
NR_172882.1
NM_005226.4	NP_005217.2	sphingosine 1-phosphate receptor 3
NM_001001938.4

S1PR3 Protein Structure

7tm_1

0
100
200
300
378 a.a.

Protein Preferred Names

Protein Names

sphingosine 1-phosphate receptor 3

G protein-coupled receptor, endothelial differentiation gene-3	S1P receptor 3
S1P receptor EDG3	S1P receptor Edg-3
endothelial differentiation G-protein coupled receptor 3	endothelial differentiation, sphingolipid G-protein-coupled receptor, 3
sphingosine 1-phosphate receptor Edg-3	uncharacterized protein C9orf47

Related Diseases

Diseases

Alias

Mouth Disease

Mouth Diseases

Mouth Disorders

Pulmonary Edema

Dermatitis, Atopic, 7

ATOD7	Dermatitis, Atopic, Susceptibility To, 7
Atopic Dermatitis 7	Dermatitis, Atopic 7

Basal Cell Carcinoma

Basal Cell Cancer	Basal Cell Neoplasm
Basal Cell Carcinoma Of Skin	Malignant Basal Cell Tumor
Basal Cell Tumor	Epithelioma Basal Cell
Malignant Basal Cell Neoplasm	Rodent Ulcer
Carcinoma Basal Cell	Neoplasms, Basal Cell
Basal Cell Carcinomas	Experimental Organism Basal Cell Carcinoma
Nodulo-Ulcerative Basal Cell Carcinoma	Basalioma
Basal Cell Epithelioma Of Skin	Bcc - [Basal Cell Carcinoma] Of Skin
Rodent Ulcer Of Skin	Rodent Ulcer Of Unspecified Site
Basal Cell Epithelioma Of Unspecified Site

Waardenburg Syndrome, Type 2b

Waardenburg Syndrome Type 2b	WS2B
Waardenburg Syndrome, Type Iib	Waardenburg Syndrome Type Iib

Second-Degree Atrioventricular Block

Second-Degree Heart Block	Second Degree Atrioventricular Block
Second Degree Atrioventricular Heart Block	Second Degree Heart Block
Incomplete Atrioventricular Block, Second Degree Nos	Second-Degree Block, Type 1 And 2
Atrioventricular Block, Type 1 And 2	Second Degree Incomplete Atrioventricular Block
Av - [Atrioventricular] Block 2nd

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12355	Siponimod	Agonist	98.88%	Yes
HY-10569	Ponesimod	Agonist	99.81%	Yes
HY-12355A	Siponimod hemifumarate	Agonist	/	Unkown

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-119401	CAY10444	Antagonist	≥98.0%	Unkown
HY-113934	L-threo Lysosphingomyelin (d18:1)	Agonist	≥98.0%	Unkown
HY-111253	CYM-5478	Agonist	/	Unkown
HY-108492	TC-SP 14	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	S1PR3	RGD	RGD:1583843
Bos taurus	S1PR3	VGNC	VGNC:34254
Mus musculus	S1PR3	MGD	MGI:1339365
Felis catus	S1PR3	VGNC	VGNC:64847
Canis familiaris	S1PR3	VGNC	VGNC:45837

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