1. GPCR/G Protein
    Neuronal Signaling
  2. GHSR
    Adrenergic Receptor
  3. Ulimorelin

Ulimorelin (Synonyms: TZP-101)

Cat. No.: HY-14903
Handling Instructions

Ulimorelin (TZP-101) is a ghrelin receptor (GRLN) agonist with an EC50 of 29 nM and a Ki of 16 nM. Ulimorelin is a prokinetic agent and causes vasorelaxation through competitive antagonist action at α1-adrenoceptors. Ulimorelin stimulates intestinal motility and is used for malnutrition.

For research use only. We do not sell to patients.

Ulimorelin Chemical Structure

Ulimorelin Chemical Structure

CAS No. : 842131-33-3

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Ulimorelin (TZP-101) is a ghrelin receptor (GRLN) agonist with an EC50 of 29 nM and a Ki of 16 nM. Ulimorelin is a prokinetic agent and causes vasorelaxation through competitive antagonist action at α1-adrenoceptors. Ulimorelin stimulates intestinal motility and is used for malnutrition[1][2][3].

In Vivo

Ulimorelin (TZP-101; 0.3-5 mg/kg; i.v.) causes a dose dependent increase in the numbers and amplitudes of phasic pressure waves recorded from the colorectum[1].
Ulimorelin (1, 3, 5 mg/kg; i.v.) causes a substantial and prolonged (~1 h) increase in colorectal propulsive activity and expulsion of colonic contents[1].
Ulimorelin (p.o.; 8 mg/kg) has a Cmax of 0.39 μM and a AUC of 82 μM•min for rats. Ulimorelin (i.v.; 2 mg/kg) has a T1/2 of 50 mins, a CL of 24 mL/min/kg, and a Vss of 1.7 L/kg for rats[3].

Animal Model: Male Sprague-Dawley rats[1]
Dosage: 0.3, 1, 3, 5 mg/kg
Administration: i.v.
Result: Caused a dose dependent increase in the numbers and amplitudes of phasic pressure waves recorded from the colorectum.
Clinical Trial
Molecular Weight

538.65

Formula

C₃₀H₃₉FN₄O₄

CAS No.

842131-33-3

SMILES

O=C(N(C)[[email protected]](C)C(N[[email protected]@H]1CC2=CC=C(F)C=C2)=O)[[email protected]](C3CC3)NC[[email protected]@H](C)OC4=CC=CC=C4CCCNC1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

UlimorelinTZP-101TZP101TZP 101GHSRAdrenergic ReceptorGrowth hormone secretagogue receptorBeta ReceptorGhrelinreceptorprokineticvasorelaxationα1-adrenoceptorsintestinalmotilitymalnutritionInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Ulimorelin
Cat. No.:
HY-14903
Quantity:
MCE Japan Authorized Agent: