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Cat. No.: HY-131531A

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5-OH-DPAT

(Synonyms: 5-Hydroxy-DPAT)

5-OH-DPAT (5-Hydroxy-DPAT) is a potent and selective dopamine D2-receptor agonist lacking effects at 5-HT receptors. 5-OH-DPAT produces a moderate facilitation of the male rat sexual behavior.

For research use only. We do not sell to patients.

CAS No.: 68593-96-4
Formula: C₁₆H₂₅NO
Molecular Weight:247.38

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

5-OH-DPAT Chemical Structure

CAS No.: 68593-96-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

5-OH-DPAT (5-Hydroxy-DPAT) is a potent and selective dopamine D2-receptor agonist lacking effects at 5-HT receptors. 5-OH-DPAT produces a moderate facilitation of the male rat sexual behavior^[1]^[2].

IC₅₀ & Target^[1]^[2]

D₂ Receptor

All Dopamine Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
AtT20	EC₅₀	1.23 nM Compound: 5-OH-DPAT	Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding	[PMID: 20038106]

Chemical Information

CAS No. 68593-96-4
Molecular Weight 247.38
Formula C₁₆H₂₅NO
SMILES

OC1=CC=CC2=C1CCC(N(CCC)CCC)C2
Synonyms

5-Hydroxy-DPAT
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ahlenius S, et al. Evidence for selective inhibition of limbic forebrain dopamine synthesis by 8-OH-DPAT in the rat. Naunyn Schmiedebergs Arch Pharmacol. 1989 May;339(5):551-6. [Content Brief]

[2]. Karlsson A, et al. (R)- and (S)-5-hydroxy-2-(dipropylamino)tetralin (5-OH DPAT): assessment of optical purities and dopaminergic activities. Chirality. 1990;2(2):90-5. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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5-OH-DPAT

All Dopamine Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

5-OH-DPAT Related Classifications

HY-131531A Related Classifications