VEGFR-2-IN-19
VEGFR-2-IN-19 (Compound 15b) is a potent VEGFR2 inhibitor. VEGFR-2-IN-19 induces cell apoptosis and increases intracellular reactive oxygen species level. VEGFR-2-IN-19 can be used as an anticancer agent.
For research use only. We do not sell to patients.
- CAS No.: 2456315-41-4
- Formula: C21H19N3O2
- Molecular Weight:345.39
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All VEGFR Isoforms
More
Biological Activity
|
VEGFR2 |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.63 μM
Compound: 15b
|
Antiproliferative activity against human A549 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
|
[PMID: 32663641] |
| HT-29 | IC50 |
3.38 μM
Compound: 15b
|
Antiproliferative activity against human HT-29 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human HT-29 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
|
[PMID: 32663641] |
VEGFR-2-IN-19 (Compound 15b) (0-100 µM, 48 h) shows antiproliferative activity against cancer cells[1].
VEGFR-2-IN-19 (0-10 µM, 48 h) inhibits the phosphorylation of VEGFR2 and the Raf/MEK/ERK signaling pathway, induces cell apoptosis, and arrests cell cycle at G0/G1 phase in HT-29 cells[1].
VEGFR-2-IN-19 (0-10 µM, 12 h) increases intracellular reactive oxygen species level in HT-29 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HT-29 and A549
-
Concentration:0-100 µM
-
Incubation Time:48 h
-
Result:Showed antiproliferative activity with IC50 values of 3.38±1.3 µM and 0.63±0.04 µM against HT-29 and A549 cells, respectively.
-
Cell Line:HT-29
-
Concentration:0, 1, 5, and 10 µM
-
Incubation Time:48 h
-
Result:Effectively inhibited the phosphorylation of VEGFR2 in dose-dependent manner. Suppressed dose-dependently expression of c-Raf, ERK1/2, and MEK and phosphorylation of ERK1/2 (pERK1/2). Up-regulated caspase-3 and Bax expression, down-regulated Bcl-2 expression.
-
Cell Line:HT-29
-
Concentration:0, 1, 5, and 10 µM
-
Incubation Time:48 h
-
Result:The total numbers of early and late apoptotic cells were increased significantly relative to that of untreated control cells in dose-dependent manner.
-
Cell Line:HT-29
-
Concentration:0, 1, 5, and 10 µM
-
Incubation Time:48 h
-
Result:Increased the population of cells in sub G1 and G0/G1 phase and decreased the population of cells in S phase.
Chemical Information
-
CAS No. 2456315-41-4
-
Molecular Weight 345.39
-
Formula C21H19N3O2
-
SMILES
O=C(NC1=CC=C(C=C1)NC(NC2=CC=CC=C2)=O)CC3=CC=CC=C3
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
VEGFR-2-IN-19 Related Classifications
HY-146367 Related Classifications
Powered by Bioz