VEGFR-2-IN-30
VEGFR-2-IN-30 is a VEGFR-2 inhibitor (IC50: 66 nM). VEGFR-2-IN-30 also inhibits PDGFR, EGFR and FGFR1 with IC50s of 180, 98, 82 nM respectively. VEGFR-2-IN-30 arrests cancer cell at S-phase and induces early and late apoptosis.
For research use only. We do not sell to patients.
- CAS No.: 3037960-64-5
- Formula: C28H23ClN6O4S2
- Molecular Weight:607.10
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
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VEGFR2 66 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RPTEC | IC50 |
48.33 μM
Compound: 8f
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Cytotoxicity against human RPTEC cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
Cytotoxicity against human RPTEC cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
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[PMID: 36395650] |
| UO-31 | IC50 |
4.52 μM
Compound: 8f
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Cytotoxicity against human UO-31 cells assessed as inhibition of cell growth preincubated for 2 hrs followed by administration of single dose of 8 Gy gamma irradiation for 21.4 mins and measured 24 hrs after irradiation by MTT assay
Cytotoxicity against human UO-31 cells assessed as inhibition of cell growth preincubated for 2 hrs followed by administration of single dose of 8 Gy gamma irradiation for 21.4 mins and measured 24 hrs after irradiation by MTT assay
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[PMID: 36395650] |
| UO-31 | IC50 |
5.29 μM
Compound: 8f
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Cytotoxicity against human UO-31 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
Cytotoxicity against human UO-31 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
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[PMID: 36395650] |
VEGFR-2-IN-30 (compound 8f) (10 μM) inhibits UO-31 cell growth by 35%[1].
VEGFR-2-IN-30 (10 μg/mL, 72 h) inhibits HUVEC cell migration[1].
VEGFR-2-IN-30 (5.29 μM, 24 h) arrests UO-31 cells at the S phase[1].
VEGFR-2-IN-30 (5.29 μM, 24 h) induces UO-31 cell apoptosis[1].
VEGFR-2-IN-30 (5.29 μM, 24 h) increases the Bax level and down-regulates Bcl-2 level in UO-31 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:NHUVEC
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Concentration:10 μg/mL
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Incubation Time:72 h
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Result:Inhibited cell migration by 58.52%.
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Cell Line:UO-31 cell
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Concentration:5.29 μM
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Incubation Time:24 h
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Result:Increased early apoptotic cells from 0.61% to 23.51% and late apoptotic cells from 0.13% to 9.28%.
Increased the level of active caspase-3.
Chemical Information
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CAS No. 3037960-64-5
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Molecular Weight 607.10
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Formula C28H23ClN6O4S2
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SMILES
O=C(NC1=CC=C(C=C1)S(=O)(NC2=NN=C(C=C2)Cl)=O)CSC3=NC4=CC=CC=C4C(N3CCC5=CC=CC=C5)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
VEGFR-2-IN-30 Related Classifications
HY-151969 Related Classifications
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