1. Protein Tyrosine Kinase/RTK
  2. VEGFR
  3. VEGFR-2-IN-30

VEGFR-2-IN-30 is a VEGFR-2 inhibitor (IC50: 66 nM). VEGFR-2-IN-30 also inhibits PDGFR, EGFR and FGFR1 with IC50s of 180, 98, 82 nM respectively. VEGFR-2-IN-30 arrests cancer cell at S-phase and induces early and late apoptosis.

For research use only. We do not sell to patients.

VEGFR-2-IN-30 Chemical Structure

VEGFR-2-IN-30 Chemical Structure

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Description

VEGFR-2-IN-30 is a VEGFR-2 inhibitor (IC50: 66 nM). VEGFR-2-IN-30 also inhibits PDGFR, EGFR and FGFR1 with IC50s of 180, 98, 82 nM respectively. VEGFR-2-IN-30 arrests cancer cell at S-phase and induces early and late apoptosis[1].

IC50 & Target[1]

VEGFR2

66 nM (IC50)

In Vitro

VEGFR-2-IN-30 (compound 8f) (10 μM) inhibits UO-31 cell growth by 35%[1].
VEGFR-2-IN-30 (10 μg/mL, 72 h) inhibits HUVEC cell migration[1].
VEGFR-2-IN-30 (5.29 μM, 24 h) arrests UO-31 cells at the S phase[1].
VEGFR-2-IN-30 (5.29 μM, 24 h) induces UO-31 cell apoptosis[1].
VEGFR-2-IN-30 (5.29 μM, 24 h) increases the Bax level and down-regulates Bcl-2 level in UO-31 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Migration Assay [1]

Cell Line: NHUVEC
Concentration: 10 μg/mL
Incubation Time: 72 h
Result: Inhibited cell migration by 58.52%.

Apoptosis Analysis[1]

Cell Line: UO-31 cell
Concentration: 5.29 μM
Incubation Time: 24 h
Result: Increased early apoptotic cells from 0.61% to 23.51% and late apoptotic cells from 0.13% to 9.28%.
Increased the level of active caspase-3.
Molecular Weight

607.10

Formula

C28H23ClN6O4S2

SMILES

O=C(NC1=CC=C(C=C1)S(=O)(NC2=NN=C(C=C2)Cl)=O)CSC3=NC4=CC=CC=C4C(N3CCC5=CC=CC=C5)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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VEGFR-2-IN-30 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
VEGFR-2-IN-30
Cat. No.:
HY-151969
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