3037960-64-5
3037960-64-5
Chemical Structure
VEGFR-2-IN-30
- CAS No.: 3037960-64-5
- Formula:C28H23ClN6O4S2
- Molecular Weight:607.10
IUPAC Name: 3-((2-(2,6-dimethyl-4-(7-methyl-4-oxo-3,4,5,6,7,8-hexahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-2-yl)phenoxy)acetoxy)methyl)-4-phenyl-1,2,5-oxadiazole 2-oxide
InChIKey: YUPIIDJKIACQNI-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(C=C1)S(=O)(NC2=NN=C(C=C2)Cl)=O)CSC3=NC4=CC=CC=C4C(N3CCC5=CC=CC=C5)=O
Biological Activity: VEGFR-2-IN-30 is a VEGFR-2 inhibitor (IC50: 66 nM). VEGFR-2-IN-30 also inhibits PDGFR, EGFR and FGFR1 with IC50s of 180, 98, 82 nM respectively. VEGFR-2-IN-30 arrests cancer cell at S-phase and induces early and late apoptosis[1].
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VEGFR-2-IN-30 | VEGFR-2-IN-30 is a VEGFR-2 inhibitor (IC50: 66 nM). VEGFR-2-IN-30 also inhibits PDGFR, EGFR and FGFR1 with IC50s of 180, 98, 82 nM respectively. VEGFR-2-IN-30 arrests cancer cell at S-phase and induces early and late apoptosis. | |||||||||||||||||||||
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