1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Vibegron

Vibegron (Synonyms: MK-4618)

Cat. No.: HY-19933
Handling Instructions

Vibegron (MK-4618) is a potent, highly selective β3-adrenoceptor agonist (EC50=1.1 nM). Vibegron can be used for severe urgency urinary incontinence related to overactive bladder.

For research use only. We do not sell to patients.

Vibegron Chemical Structure

Vibegron Chemical Structure

CAS No. : 1190389-15-1

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Description

Vibegron (MK-4618) is a potent, highly selective β3-adrenoceptor agonist (EC50=1.1 nM). Vibegron can be used for severe urgency urinary incontinence related to overactive bladder[1][2][3].

IC50 & Target

β3 adrenoceptor

1.1 nM (EC50)

In Vivo

Vibegron (1~12 μΜ; i.v.) exhibits dose dependent decreases in micturition pressure and increases in functional bladder capacity[3].
Vibegron (30 mg/kg; p.o.; 4 weeks) upregulates mRNA levels of type 1, type 3 collagen, TGF‐β1, and HIF‐1α[4].
Vibegron (1 and 10 mg/kg; i.v.; interval 30 minutes) (10 mg/kg) in oxo-M-treated rats makes bladder capacity significantly decreased compared with oxo-M-not treated rats (intravesical instillation of vehicle)[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat
Dosage: 1~12 μΜ
Administration: I.v.
Result: Exhibited dose dependent decreases in micturition pressure and increases in functional bladder capacity.
Animal Model: Female C57BL/6N mice (9 weeks old)
Dosage: 30 mg/kg
Administration: P.o.; 4 weeks
Result: Upregulated mRNA levels of type 1, type 3 collagen, TGF‐β1, and HIF‐1α at 4 weeks.
Animal Model: Female F344 rats (120–160 g)
Dosage: 1 and 10 mg/kg
Administration: I.v.; Interval 30 minutes
Result: Vibegron (10 mg/kg) in oxo-M-treated rats made bladder capacity significantly decreased compared with oxo-M-not treated rats (intravesical instillation of vehicle).
Molecular Weight

444.53

Formula

C₂₆H₂₈N₄O₃

CAS No.
SMILES

O=C([[email protected]@H]1CCC2=NC=CC(N21)=O)NC3=CC=C(C[[email protected]]4N[[email protected]@H]([[email protected]](O)C5=CC=CC=C5)CC4)C=C3

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

VibegronMK-4618MK4618MK 4618Adrenergic ReceptorBeta ReceptorPotentSelectiveUrgencyUrinaryIncontinenceOveractiveBladderInhibitorinhibitorinhibit

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Vibegron
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