2-Ethyl-3-methylpyrazine
Based on 1 Customer Validation
2-Ethyl-3-methylpyrazine is a GABAA receptor potentiator, Antibacterial agent and Antifungal agent, with a Kp of 1.14 mM for GABAA. 2-Ethyl-3-methylpyrazine forms via the Maillard reaction in sunflower seeds and also exists in the crust of wheat bread. 2-Ethyl-3-methylpyrazine regulates mood or states of consciousness via central GABAA receptors. 2-Ethyl-3-methylpyrazine inhibits the growth of Ralstonia solanacearum and Magnaporthe oryzae. 2-Ethyl-3-methylpyrazine acts as an anxiolytic. 2-Ethyl-3-methylpyrazine is one of the sources of cocoa aroma, imparting nutty, corn-like, burnt, cereal, roasted and earthy flavors to foods. 2-Ethyl-3-methylpyrazine can be used in studies related to anxiety disorders and plant bacterial, fungal and oomycete infections.
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- CAS No.: 15707-23-0
- 화학식: C7H10N2
- 분자량:122.17
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보관:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
2-Ethyl-3-methylpyrazine (0.01% (v/v), 0.8 mM) potently potentiates GABA-induced responses of bovine GABAₐ receptors expressed in Xenopus oocytes, with a maximum potentiation magnitude of 555% and a dissociation constant (Kp) of 1.14 mM[1].
2-Ethyl-3-methylpyrazine (335-672 µg/mL) inhibits the growth of Ralstonia solanacearum in a dose-dependent manner, with an inhibition rate of up to 95.9% at the concentration of 672 µg/mL[2].
2-Ethyl-3-methylpyrazine (168 µg/mL) completely inhibits the mycelial growth of Magnaporthe oryzae[2].
2-Ethyl-3-methylpyrazine inhibits the growth of the phytopathogenic fungus Gibberella moniliformis[2].
2-Ethyl-3-methylpyrazine inhibits the growth of the phytopathogenic fungus Phaeomoniella chlamydospora[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
2-Ethyl-3-methylpyrazine (100 mg/kg; i.p.; twice daily; 2 days) exhibits anti-anxiety activity in Mus musculus, as shown by significant increases in open arm entries and open arm stay time in an elevated plus maze test following 100 mg/kg intraperitoneal dosing twice daily for 2 days[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ICR mice (male, 7-10 weeks old, 32-40 g)[1]
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Dosage:25 mg/kg; 100 mg/kg
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Administration:i.p.; single dose
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Result:Prolonged pentobarbital-induced sleeping time significantly relative to control at 100 mg/kg.
Doubled the sleeping time compared to control at 25 mg/kg.
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Animal Model:ICR mice (male, 7-10 weeks old, 32-40 g)[1]
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Dosage:100 mg/kg
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Administration:i.p.; twice daily; 2 days
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Result:Increased the number of entries into the open arms significantly relative to control.
Increased the duration of stay in the open arms significantly relative to control.
Chemical Information
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CAS No. 15707-23-0
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Appearance Liquid
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분자량 122.17
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화학식 C7H10N2
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SMILES
CCC1=C(N=CC=N1)C
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
순도&문서
References
[1]. Mitou M, et al. Effect of dried bonito (katsuobushi) and some of its components on GABAA receptors. Food Chem. 2008 Jun 1;108(3):840-6. [Content Brief]
[3]. Fayek NM, et al. A multifunctional study of naturally occurring pyrazines in biological systems; formation mechanisms, metabolism, food applications and functional properties. Crit Rev Food Sci Nutr. 2023;63(21):5322-5338. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2-Ethyl-3-methylpyrazine Related Classifications
HY-W012832 Related Classifications
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