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Signaling Pathway

4'-Demethylepipodophyllotoxin

HY-17435

(4'-O-demethylepipodophyllotoxin; 4'-DMEP)

4'-Demethylepipodophyllotoxin

4'-Demethylepipodophyllotoxin Chemical Structure

4'-Demethylepipodophyllotoxin(4'-DMEP) is a key intermediate compound for the preparation of podophyllotoxin-type anti-cancer drugs; a potent inhibitor of microtubule assembly.

Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO $55 In-stock
50 mg $50 In-stock
100 mg $65 In-stock
200 mg Get quote
500 mg Get quote
Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO €54 In-stock
50 mg €49 In-stock
100 mg €64 In-stock
200 mg Get quote
500 mg Get quote

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Inquiry Information
Product name: 4'-Demethylepipodophyllotoxin
Cat. No.: HY-17435

4'-Demethylepipodophyllotoxin Data Sheet

  • View current batch:

    Purity: 98.25%

  • Network Version

    DataSheet

    Pdf Version Network Version

    MSDS

    Pdf Version

    COA

Related Compound Libraries

Biological Activity of 4'-Demethylepipodophyllotoxin

4'-Demethylepipodophyllotoxin(4'-DMEP) is a key intermediate compound for the preparation of podophyllotoxin-type anti-cancer drugs; a potent inhibitor of microtubule assembly.
IC50 Value: 0.31uM(EC5 0in HL60 cell, MTT assay, 48h); 0.37uM(EC50 in HepG2 cell, MTT assay, 48h) [1]
Target: microtubule
in vitro: 4-TMP-DMEP showed strong cytotoxicity activity against the above-mentioned five tumor cell lines. The EC50s of 4-TMP-DMEP against these tumor cell lines ranged from 0.24 to 0.11 μM, which were 0.29 to 3618 times lower than that of DMEP [1].
in vivo: Treatment of animals with DMEP (until the end of the experiment), 30 min before TPA treatment, significantly reduced the tumor incidence, tumor volume and the conversion efficiency of papillomas to squamous cell carcinomas. The tumor formation and growth was also delayed by DMEP pre-treatment [2].

Chemical Information

M.Wt 400.38 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C₂₁H₂₀O₈
CAS No 6559-91-7
Solvent & Solubility

10 mM in DMSO

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.4976 mL 12.4881 mL 24.9763 mL
5 mM 0.4995 mL 2.4976 mL 4.9953 mL
10 mM 0.2498 mL 1.2488 mL 2.4976 mL

References on 4'-Demethylepipodophyllotoxin

Inhibitor Kit

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