2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. Budipine

Budipine 

Cat. No.: HY-W001601 Purity: 99.23%
COA Handling Instructions

Budipine is an anti-parkinson agent. Budipine also is a substrate of P-glycoprotein (P-gp), is mediated the uptake into the brain by P-gp. Budipine also is N-methyl-d-aspartate (NMDA) antagonist, and has indirect dopaminergic effects through an improved dopamine release, the inhibition of monoamine oxidase type B (MAO-B). Budipine can be used for the research of CNS disorders include Parkinson disease.

For research use only. We do not sell to patients.

Budipine Chemical Structure

Budipine Chemical Structure

CAS No. : 57982-78-2

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 82 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 82 In-stock
Solid
5 mg USD 75 In-stock
10 mg USD 120 In-stock
50 mg USD 450 In-stock
100 mg   Get quote  
200 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Budipine Related Antibodies

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  • Purity & Documentation

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Description

Budipine is an anti-parkinson agent. Budipine also is a substrate of P-glycoprotein (P-gp), is mediated the uptake into the brain by P-gp. Budipine also is N-methyl-d-aspartate (NMDA) antagonist, and has indirect dopaminergic effects through an improved dopamine release, the inhibition of monoamine oxidase type B (MAO-B). Budipine can be used for the research of CNS disorders include Parkinson disease[1].

IC50 & Target

NMDA Receptor

 

In Vivo

Budipine (s.c., 30 μg/24 h, 11 days) is a substrate of P-glycoprotein (P-gp) and is actively transported out of the brain through the blood–brain barrier back into the blood plasma[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male abcblab(-/-) mice[1]
Male abcblab(-/-) mice (n=8, weight 29.0 g) and FVB/N wild-type mice (n =8, weight 28.0 g)
Dosage: 30 μg
(Budipine is dissolved in 0.9% sodium chloride and 0.5% ethanol)
Administration: subcutaneous injections, continuously delivered 30 μg over 24 h, 11 days
Result: Increased the cerebrum concentration for 3.1 times high in knock-out mice after an 11-day continuous administration.
Showed no significant differences in plasma, spleen, kidney and liver.
Molecular Weight

293.45

Appearance

Solid

Formula

C21H27N
CAS No.
SMILES

CC(N1CCC(C2=CC=CC=C2)(C3=CC=CC=C3)CC1)(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (85.19 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4077 mL 17.0387 mL 34.0774 mL
5 mM 0.6815 mL 3.4077 mL 6.8155 mL
10 mM 0.3408 mL 1.7039 mL 3.4077 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.52 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.52 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Budipine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Budipine57982-78-2iGluRIonotropic glutamate receptorsP-glycoprotein (P-gp)N-methyl-d-aspartate (NMDA)monoamine oxidase type B (MAO-B)dopaminergicCNS disordersParkinson diseaseInhibitorinhibitorinhibit

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