製品番号: HY-17034A

Dexmedetomidine (hydrochloride)

Name: Dexmedetomidine (hydrochloride)
Brand: MedChemExpress
SKU: HY-17034A
Price: 55.00 USD
Availability: InStock
Rating: 5 (35 reviews)

(別名: (+)-Medetomidine (hydrochloride); デクスメデトミジン塩酸塩; (S)-Medetomidine (hydrochloride))

35 Cited Publications

カスタマーレビュー

Based on 35 publication(s) in Google Scholar

Dexmedetomidine hydrochloride ((+)-Medetomidine hydrochloride) is a potent, selective and orally active agonist of α2-adrenoceptor, with a K_i of 1.08 nM. Dexmedetomidine hydrochloride shows 1620-fold selectivity against α1-adrenoceptor. Dexmedetomidine hydrochloride exhibits anxiolysis, sedation, and modest analgesia effects.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度 : 99.94%
CAS 番号: 145108-58-3
分子式: C₁₃H₁₇ClN₂
分子量:236.74

保管条件:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Dexmedetomidine hydrochloride 構造式

CAS 番号: 145108-58-3

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
- 臨床実験
化学情報
Publications (35)
溶剤 & 溶解度
- 体外
- 体内
純度とドキュメンテーション
参考文献
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

^[1]

α2-adrenergic receptor

1.08 nM (IC₅₀)

Adrenergic Receptor アイソフォーム固有の製品をすべて表示 :

体外実験

Medetomidine has high selectivity for α2-adrenoceptor, (K_i=1.08 nM) over α1 adrenoceptors (K_i=1750 nM) in rat brain membranes as measured by the displacement of [³H]clonidine^[1].
Medetomidine (0.1-100 nM) inhibits the twitch response in field-stimulated mouse vas deferens, with a pD₂ of 9.0^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

体内実験

Medetomidine (10-100 μg/kg; i.v. at 5-min intervals) produces a dose-dependent pupillary dilatation in pentobarbitone-anaesthetized rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Female Sprague-Dawley rats (270-350 g)^[1]
Dosage:

1, 5, 10, 50, 100 mg/kg
Administration:

I.v. at 5-min intervals
Result:

Produced the pupil dilatation of 2.5 mm (approximately half of the maximum effect) at the cumulative dose of 4 μg/kg.

臨床実験

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

化学情報

CAS 番号 145108-58-3
性状 Solid
分子量 236.74
分子式 C₁₃H₁₇ClN₂
Color White to off-white
SMILES

C[C@H](C1=CN=CN1)C2=CC=CC(C)=C2C.Cl
別名

(+)-Medetomidine (hydrochloride); デクスメデトミジン塩酸塩; (S)-Medetomidine (hydrochloride)
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (35)

All Cell Imaging/StainingHistological Imaging/StainingBio/Physico-chemical AssayRT-PCRIF

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Journal Impact Factor

Nat Commun

Porous microneedle patch with sustained delivery of extracellular vesicles mitigates severe spinal cord injury. [Abstract]

2023 Jul 7;14(1):4011. PMID: 37419902
Am J Chin Med

Ophiopogonin D from Ophiopogon japonicas-induced USP25 Activity to Reduce Ferroptosis of Macrophage in Acute Lung Injury by the Inhibition of Bound Rac1 and Nox1 Complex. [Abstract]

2025;53(2):501-522. PMID: 40099394
Cell Rep

Glymphatic influx is negatively correlated with cerebral blood volume in male mice. [Abstract]

2026 Mar 28;45(4):117182. PMID: 41904953
Drug Des Devel Ther

Dexmedetomidine Prolongs Lidocaine Intravenous Regional Anesthesia in Rats by Blocking the Hyperpolarization-Activated Cation Current. [Abstract]

2024 Apr 9:18:1103-1114. PMID: 38618283
Cancer Metab

Dexmedetomidine promotes colorectal cancer progression mediated by gamma-aminobutyric acid signaling. [Abstract]

2025 Jun 23;13(1):33. PMID: 40551256
J Ovarian Res

2026 Apr 28;19(1):209. PMID: 42046103
Sci Rep

Dexmedetomidine regulates the SIRT3-mediated JAK2/STAT3 signaling pathway to protect against sepsis-induced intestinal injury. [Abstract]

2025 Sep 29;15(1):33699. PMID: 41023284
Mol Cell Biochem

Dexmedetomidine inhibits microglia activation, neuroinflammation, and glycolysis in postoperative cognitive dysfunction by promoting YTHDF2-mediated PKM2 mRNA degradation. [Abstract]

2026 May;481(5):2083-2095. PMID: 41925799
Mol Cell Biochem

Decoding dexmedetomidine's multiple mechanisms in atherosclerosis: effects on lipid metabolism, inflammation, cholesterol efflux, and foam cell formation. [Abstract]

2026 Mar 13. PMID: 41824202
Brain Res Bull

Dexmedetomidine ameliorates postoperative delirium-like behavior in aged mice by restoring microglial autophagy via MAPK14 inhibition. [Abstract]

2026 Apr:237:111839. PMID: 41865902
Brain Res Bull

Dexmedetomidine attenuates postoperative delirium by activating Nrf2 to reduce oxidative stress and blood-brain barrier disruption. [Abstract]

2025 Aug 24:230:111523. PMID: 40858194
Neurochem Res

Dexmedetomidine Promotes Angiogenesis After Ischemic Stroke Through the NRF2/HO-1/VEGF Pathway. [Abstract]

2025 Apr 9;50(2):138. PMID: 40202562
Front Biosci (Landmark Ed)

Dexmedetomidine Protects the Brain: Exploring the α2AR/FAK Pathway in Post-Stroke Intestinal Barrier Repair. [Abstract]

2025 Feb 20;30(2):27159. PMID: 40018945
Metab Brain Dis

Dexmedetomidine alleviates ferroptosis caused by traumatic brain injury via the NRF2/HO-1/GPX4 pathway. [Abstract]

2025 Nov 5;40(8):306. PMID: 41191138
Hum Exp Toxicol

Protective effects of dexmedetomidine against propofol-induced memory impairment in developing rat involved Src and RARα. [Abstract]

2025 Jan-Dec:44:9603271251336467. PMID: 40296644
Cardiovasc Drugs Ther

Dexmedetomidine Alleviates Abdominal Aortic Aneurysm by Activating Autophagy Via AMPK/mTOR Pathway. [Abstract]

2025 Feb;39(1):33-42. PMID: 37392236
Hum Exp Toxicol

Protective effect of dexmedetomidine on neuronal hypoxic injury through inhibition of miR-134. [Abstract]

2021 Dec;40(12):2145-2155. PMID: 34121490
Chem Biol Drug Des

The Role of the Sirt1/Foxo3a Pathway in Mitigating Myocardial Ischemia-Reperfusion Injury by Dexmedetomidine. [Abstract]

2025 Apr;105(4):e70100. PMID: 40230274
J Neuropathol Exp Neurol

Dexmedetomidine Inhibits NF-κB-Transcriptional Activity in Neurons Undergoing Ischemia-Reperfusion by Regulating O-GlcNAcylation of SNW1. [Abstract]

2022 Sep 19;81(10):836-849. PMID: 35818332
BMC Anesthesiol

Dexmedetomidine may alleviate severe acute pancreatitis-associated lung injury by targeting the AIM2 inflammasome in endothelial cells. [Abstract]

2026 Jun 1. PMID: 42226110
Brain Res

Role of dexmedetomidine in postoperative cognitive dysfunction and sleep improvement in aged rats by regulating the PI3K/Akt signaling pathway and its mechanism. [Abstract]

2025 Apr 1:1852:149482. PMID: 39892804
Tissue Cell

Rosmarinic acid ameliorates radiation-induced intestinal injury through PI3K/AKT/NF-κB/MMP9 axis inhibition: From network pharmacology prediction to experimental validation. [Abstract]

2026 Jun 8:103:103683. PMID: 42269422
BMC Cardiovasc Disord

2026 Jun 25. PMID: 42350955
Kaohsiung J Med Sci

Dexmedetomidine Blocks the ERK Pathway by Inhibiting MAP3K8 to Achieve a Protective Effect in Lung Ischemia/Reperfusion Injury. [Abstract]

2025 Sep;41(9):e70045. PMID: 40372180
Dose Response

Dexmedetomidine Improves BBB and Neuronal Damage in Subarachnoid Hemorrhage by Repressing S100A4-Mediated Astrocytic Reactivity. [Abstract]

2026 Apr 24;24(2):15593258261445031. PMID: 42064389
Pharmacology

Dexmedetomidine Attenuates Hypoxia/Reoxygenation Injury of H9C2 Myocardial Cells by Upregulating miR-146a Expression via the MAPK Signal Pathway. [Abstract]

2022;107(1-2):14-27. PMID: 34718238
J Pharm Innov

2026 Jul 1;22(1):4.
Eur J Neurosci

Dexmedetomidine attenuates propofol-induced apoptosis of neonatal hippocampal astrocytes by inhibiting the Bcl2l1 signalling pathway. [Abstract]

2021 Dec;54(11):7775-7789. PMID: 34734676
Histol Histopathol

The mechanism of dexmedetomidine regulation of the HIF-1α/FUNDC1 axis in myocardial ischemia/reperfusion injury. [Abstract]

2025 Dec;40(12):2047-2058. PMID: 40235277
Exp Brain Res

Dexmedetomidine inhibits microglia ferroptosis to relieve postoperative cognitive dysfunction in elderly rats through JPX/HIF-1/DHODH pathway. [Abstract]

2026 Jun 15;244(7):135. PMID: 42295409
J Toxicol Sci

Dexmedetomidine protects against Ropivacaine-induced neuronal pyroptosis via the Nrf2/HO-1 pathway. [Abstract]

2023;48(3):139-148. PMID: 36858639
Mol Cell Toxicol

2023 Jun 2.
bioRxiv

2026 Mar 7.
University of Colorado Denver

2024.
Biomed Pharmacother

Dexmedetomidine alleviates ferroptosis following hepatic ischemia-reperfusion injury by upregulating Nrf2/GPx4-dependent antioxidant responses. [Abstract]

2023 Dec 31:169:115915. PMID: 38000361

Dexmedetomidine hydrochloride purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2023 Dec 31:169:115915. [Abstract]

Dexmedetomidine (Dex) (10 nM; 24 h) treatment significantly reduced the number of AML12 cells damaged via OGD/R.

Dexmedetomidine hydrochloride purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2023 Dec 31:169:115915. [Abstract]

Dexmedetomidine (Dex) (50 mg/kg; i.p.) treatment significantly ameliorated the hepatic pathological changes in the HIRI mice.

Dexmedetomidine hydrochloride purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2023 Dec 31:169:115915. [Abstract]

Dexmedetomidine (Dex) (50 mg/kg; i.p.) treatment significantly reduced ALT and AST levels in the HIRI model mice.

Dexmedetomidine hydrochloride purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2023 Dec 31:169:115915. [Abstract]

Dexmedetomidine (Dex) (10 nM; 24 h) increased GPX4 and SLC7A11 mRNA levels in OGD/R-induced AML12 cells.

Dexmedetomidine hydrochloride purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2023 Dec 31:169:115915. [Abstract]

Dexmedetomidine (Dex) (10 nM; 24 h) significantly increased the protein expression and nuclear levels of Nrf2 in OGD/R-treated AML12 cells.

溶剤 & 溶解度

体外:

DMSO : 250 mg/mL (1056.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : ≥ 50 mg/mL (211.20 mM)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.2240 mL

21.1202 mL

42.2404 mL

5 mM

0.8448 mL

4.2240 mL

8.4481 mL

10 mM

0.4224 mL

2.1120 mL

4.2240 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (8.79 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (8.79 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (8.79 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact

MedChemExpress (MCE) .

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

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元素分析報告書 (2659 KB)
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参考文献

[1]. Virtanen R, et, al. Characterization of the selectivity, specificity and potency of medetomidine as an alpha 2-adrenoceptor agonist. Eur J Pharmacol. 1988 May 20;150(1-2):9-14. [Content Brief]

[2]. Gertler R, et, al. Dexmedetomidine: a novel sedative-analgesic agent. Proc (Bayl Univ Med Cent). 2001 Jan;14(1):13-21. [Content Brief]

[3]. Sajid B, et, al. A comparison of oral dexmedetomidine and oral midazolam as premedicants in children. J Anaesthesiol Clin Pharmacol. Jan-Mar 2019;35(1):36-40. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	4.2240 mL	21.1202 mL	42.2404 mL	105.6011 mL
	5 mM	0.8448 mL	4.2240 mL	8.4481 mL	21.1202 mL
	10 mM	0.4224 mL	2.1120 mL	4.2240 mL	10.5601 mL
	15 mM	0.2816 mL	1.4080 mL	2.8160 mL	7.0401 mL
	20 mM	0.2112 mL	1.0560 mL	2.1120 mL	5.2801 mL
	25 mM	0.1690 mL	0.8448 mL	1.6896 mL	4.2240 mL
	30 mM	0.1408 mL	0.7040 mL	1.4080 mL	3.5200 mL
	40 mM	0.1056 mL	0.5280 mL	1.0560 mL	2.6400 mL
	50 mM	0.0845 mL	0.4224 mL	0.8448 mL	2.1120 mL
	60 mM	0.0704 mL	0.3520 mL	0.7040 mL	1.7600 mL
	80 mM	0.0528 mL	0.2640 mL	0.5280 mL	1.3200 mL
	100 mM	0.0422 mL	0.2112 mL	0.4224 mL	1.0560 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Keywords

Dexmedetomidine hydrochloride

35 Cited Publications

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Dexmedetomidine (hydrochloride)

MedChemExpress（MCE）の使用を引用している文献 Dexmedetomidine hydrochloride

Adrenergic Receptor アイソフォーム固有の製品をすべて表示

生物活性