Medetomidine hydrochloride
Based on 1 publication(s) in Google Scholar
Medetomidine hydrochloride is an orally active α2-adrenoceptor agonist (Ki: 1.08 nM). Medetomidine hydrochloride has sedative and analgesic effects. Medetomidine hydrochloride can cause peripheral vasoconstriction through the activation of α2 adrenoceptors on blood vessels.
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- Reinheit : 99.94%
- CAS. Nr.: 86347-15-1
- Formel: C13H17ClN2
- Molecular Weight:236.74
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Speicherung:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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HY-17034BR
Medetomidine hydrochloride (Standard)α2 Adrenergic Receptor Agonist -
HY-B0163A
Detomidine hydrochlorideα2-adrenergic Agonist -
HY-B0194A
Tizanidine hydrochlorideAdrenergic Receptor Agonist -
HY-B0163AR
Detomidine hydrochloride (Standard)α2-adrenergic Agonist -
HY-B0194AR
Tizanidine hydrochloride (Standard)Standard of Tizanidine hydrochloride
Publications Citing Use of MedChemExpress (MCE) Medetomidine hydrochloride
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Biologische Aktivität
Beschreibung
IC50 & Target
[3]|
α2-adrenergic receptor 1.08 nM (Ki) |
α1-adrenergic receptor 1750 nM (Ki) |
In Vitro
Medetomidine (0-1 μM, 1 h) hydrochloride inhibits aldosterone release from the adrenocortical cell suspension[7].
Medetomidine (10 nM) hydrochloride activates a kicking response in Cyprids[8].
Medetomidine (1 μM) hydrochloride increases cellular cAMP production by activating β-like receptors in CHO cells[8].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
Medetomidine (20 μg/kg, i.v.) hydrochloride shows sedative and analgesic effects in dogs[5].
Medetomidine (0.05-0.3 mg/kg, s.c.) hydrochloride protects against Diazinon-induced toxicosis in mice[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Diazinon (75 mg/kg, orally)-induced toxicosis in mice[6]
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Dosage:0.05, 0.1 and 0.3 mg/kg
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Administration:Subcutaneous injection (s.c.), 15 min before Diazinon.
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Result:Protected the mice from the toxicity induced by Diazinon.
Decreased the occurrence of Straub tail, excessive salivation and tremor.
Increased the latencies to onset of tremor and death when compared with control.
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Animal Model:Dogs[5]
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Dosage:20 µg/kg
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Administration:Intravenous injection (i.v.)
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Result:Showed sedative and analgesic effects. Increased in SAP, MAP, DAP, MPAP, PCWP, CVP, SVR, PVR, core body temperature.
Decreased in HR, CO, CI, SV, SI, RR, pH.
Chemical Information
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CAS. Nr. 86347-15-1
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Appearance Solid
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Molecular Weight 236.74
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Formel C13H17ClN2
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Color White to off-white
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SMILES
CC(C1=CN=CN1)C2=CC=CC(C)=C2C.Cl
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Synonyms
MPV785
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Sci Rep
The anticancer properties of dexmedetomidine in papillary thyroid cancer and its underlying mechanisms. [Abstract]2026 Apr 24;16(1):18943. PMID: 42032081
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 100 mg/mL (422.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Ethanol : 100 mg/mL (422.40 mM; Need ultrasonic)
H2O : ≥ 50 mg/mL (211.20 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (10.56 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (10.56 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Add each solvent one by one: 10% EtOH 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (10.56 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% EtOH 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (10.56 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Reinheit & Dokumentation
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Data Sheet (278 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Kallio A, et al. Acute effects of medetomidine, a selective alpha 2-adrenoceptor agonist, on anterior pituitary hormone and cortisol secretion in man. Acta Endocrinol (Copenh). 1988 Sep;119(1):11-5. [Content Brief]
[3]. R Virtanen, et al. Characterization of the selectivity, specificity and potency of medetomidine as an a2-adrenoceptor agonist. [Content Brief]
[4]. O. B. Ansah, et al. Comparing oral and intramuscular administration of medetomidine in cats.
[5]. Kuo WC, et al. Comparative cardiovascular, analgesic, and sedative effects of medetomidine, medetomidine-hydromorphone, and medetomidine-butorphanol in dogs. Am J Vet Res. 2004 Jul;65(7):931-7. [Content Brief]
[6]. Yakoub LK, et al. Medetomidine protection against diazinon-induced toxicosis in mice. Toxicol Lett. 1997 Sep 19;93(1):1-8. [Content Brief]
[7]. Jager LP, et al. Effects of atipamezole, detomidine and medetomidine on release of steroid hormones by porcine adrenocortical cells in vitro. Eur J Pharmacol. 1998 Apr 3;346(1):71-6. [Content Brief]
[8]. Ulrika Lind, et al. Octopamine receptors from the barnacle balanus improvisus are activated by the alpha2-adrenoceptor agonist medetomidine. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O / DMSO / Ethanol | 1 mM | 4.2240 mL | 21.1202 mL | 42.2404 mL | 105.6011 mL |
| 5 mM | 0.8448 mL | 4.2240 mL | 8.4481 mL | 21.1202 mL | |
| 10 mM | 0.4224 mL | 2.1120 mL | 4.2240 mL | 10.5601 mL | |
| 15 mM | 0.2816 mL | 1.4080 mL | 2.8160 mL | 7.0401 mL | |
| 20 mM | 0.2112 mL | 1.0560 mL | 2.1120 mL | 5.2801 mL | |
| 25 mM | 0.1690 mL | 0.8448 mL | 1.6896 mL | 4.2240 mL | |
| 30 mM | 0.1408 mL | 0.7040 mL | 1.4080 mL | 3.5200 mL | |
| 40 mM | 0.1056 mL | 0.5280 mL | 1.0560 mL | 2.6400 mL | |
| 50 mM | 0.0845 mL | 0.4224 mL | 0.8448 mL | 2.1120 mL | |
| 60 mM | 0.0704 mL | 0.3520 mL | 0.7040 mL | 1.7600 mL | |
| 80 mM | 0.0528 mL | 0.2640 mL | 0.5280 mL | 1.3200 mL | |
| 100 mM | 0.0422 mL | 0.2112 mL | 0.4224 mL | 1.0560 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Medetomidine hydrochloride Related Classifications
HY-17034B Related Classifications
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