Medetomidine

Cat. No.: HY-17034 Purity: 99.99%: FAQs
Data Sheet SDS COA Handling Instructions

Medetomidine is an orally active α2-adrenoceptor agonist (K_i: 1.08 nM). Medetomidine has sedative and analgesic effects. Medetomidine can cause peripheral vasoconstriction through the activation of α2 adrenoceptors on blood vessels.

For research use only. We do not sell to patients.

Medetomidine Chemical Structure

CAS No. : 86347-14-0

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solution
10 mM * 1 mL in DMSO	USD 66	In-stock	Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL ready for reconstitution	USD 66	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 60	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 240	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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α adrenergic receptor β adrenergic receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

α2-adrenergic receptor

1.08 nM (Ki)

α1-adrenergic receptor

1750 nM (Ki)

In Vitro

Medetomidine (0-1 µM, 1 h) inhibits aldosterone release from the adrenocortical cell suspension^[7].
Medetomidine (10 nM) activates a kicking response in Cyprids^[8].
Medetomidine (1 µM) increases cellular cAMP production by activating β-like receptors in CHO cells^[8].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Medetomidine (200 μg/kg, p.o. or i.m.) induces a sedation in cats^[4].
Medetomidine (20 µg/kg, i.v.) shows sedative and analgesic effects in dogs^[5].
Medetomidine (0.05-0.3 mg/kg, s.c.) protects against Diazinon-induced toxicosis in mice^[6].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Diazinon (75 mg/kg, orally)-induced toxicosis in mice^[6]
Dosage:	0.05, 0.1 and 0.3 mg/kg
Administration:	Subcutaneous injection (s.c.), 15 min before Diazinon.
Result:	Protected the mice from the toxicity induced by Diazinon. Decreased the occurrence of Straub tail, excessive salivation and tremor. Increased the latencies to onset of tremor and death when compared with control.

Animal Model:	Dogs^[5]
Dosage:	20 µg/kg
Administration:	Intravenous injection (i.v.)
Result:	Showed sedative and analgesic effects. Increased in SAP, MAP, DAP, MPAP, PCWP, CVP, SVR, PVR, core body temperature. Decreased in HR, CO, CI, SV, SI, RR, pH.

Molecular Weight

200.28

Appearance

Solid

Formula

C₁₃H₁₆N₂

CAS No.

86347-14-0

SMILES

CC(C1=CN=CN1)C2=CC=CC(C)=C2C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (1248.25 mM; Need ultrasonic)

H₂O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.9930 mL	24.9650 mL	49.9301 mL
5 mM	0.9986 mL	4.9930 mL	9.9860 mL
10 mM	0.4993 mL	2.4965 mL	4.9930 mL

*Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.5 mg/mL (12.48 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (12.48 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO 90% corn oil
Solubility: ≥ 2.5 mg/mL (12.48 mM); Clear solution

*All of the co-solvents are available by MCE.

Purity & Documentation

Purity: 99.99%

Select Batch:

Data Sheet (282 KB) SDS (393 KB)

COA (254 KB) LCMS (88 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Kallio A, et al. Acute effects of medetomidine, a selective alpha 2-adrenoceptor agonist, on anterior pituitary hormone and cortisol secretion in man. Acta Endocrinol (Copenh). 1988 Sep;119(1):11-5. [Content Brief]

[3]. R Virtanen, et al. Characterization of the selectivity, specificity and potency of medetomidine as an a2-adrenoceptor agonist. [Content Brief]

[4]. O. B. Ansah, et al. Comparing oral and intramuscular administration of medetomidine in cats.

[5]. Kuo WC, et al. Comparative cardiovascular, analgesic, and sedative effects of medetomidine, medetomidine-hydromorphone, and medetomidine-butorphanol in dogs. Am J Vet Res. 2004 Jul;65(7):931-7. [Content Brief]

[6]. Yakoub LK, et al. Medetomidine protection against diazinon-induced toxicosis in mice. Toxicol Lett. 1997 Sep 19;93(1):1-8. [Content Brief]

[7]. Jager LP, et al. Effects of atipamezole, detomidine and medetomidine on release of steroid hormones by porcine adrenocortical cells in vitro. Eur J Pharmacol. 1998 Apr 3;346(1):71-6. [Content Brief]

[8]. Ulrika Lind, et al. Octopamine receptors from the barnacle balanus improvisus are activated by the alpha2-adrenoceptor agonist medetomidine. [Content Brief]

Medetomidine Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Keywords:

Medetomidine86347-14-0Adrenergic ReceptorBeta ReceptorSedativeanalgesicvasoconstrictionaldosteronecAMPCHOtoxicosisInhibitorinhibitorinhibit

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