1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Dobutamine hydrochloride

Dobutamine hydrochloride 

Cat. No.: HY-15746 Purity: 98.86%
Handling Instructions

Dobutamine hydrochloride is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion.

For research use only. We do not sell to patients.

Dobutamine hydrochloride Chemical Structure

Dobutamine hydrochloride Chemical Structure

CAS No. : 49745-95-1

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 174 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 174 In-stock
Estimated Time of Arrival: December 31
Solid
100 mg USD 158 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Dobutamine hydrochloride:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Dobutamine hydrochloride

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Dobutamine hydrochloride is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion[1][2][3][4].

In Vivo

Dobutamine hydrochloride has a rapid onset of action and a short half-life [2].
Dobutamine hydrochloride (0.15-20 mg/kg; i.p.) results in subsequent increase in the left ventricular function and heart rate acceleration with an increasing dose in wildtype mice[3].
Dobutamine hydrochloride results in significant inotropic, lusitropic, and chronotropic cardiac response with a high dose in wildtype mice[3].
Low doses of Dobutamine hydrochloride significantly increases inotropic and lusitropic cardiac performance without chronotropic changes in the Tgαq*44 mice[3].
Dobutamine hydrochloride increases heart rate only after high doses, but then inotropic and lusitropic cardiac functional reserve is lost[3].
Dobutamine hydrochloride increases alveolar liquid clearance in ventilated rats by beta-2 receptor stimulation[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Tgαq*44 mice (heart failure models)[3]
Dosage: 0.15 mg/kg, 0.5 mg/kg as a low dose, 1.5 mg/kg, 5 mg/kg, 20 mg/kg as a high dose
Administration: Intraperitoneal injection
Result: Induced different response in cardiac function on a low and high dose in mice with with heart failure.
Clinical Trial
Molecular Weight

337.84

Formula

C18H24ClNO3

CAS No.
SMILES

OC1=CC=C(CCNC(C)CCC2=CC=C(O)C=C2)C=C1O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 33 mg/mL (97.68 mM)

H2O : 20 mg/mL (59.20 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9600 mL 14.7999 mL 29.5998 mL
5 mM 0.5920 mL 2.9600 mL 5.9200 mL
10 mM 0.2960 mL 1.4800 mL 2.9600 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 16.67 mg/mL (49.34 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.40 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.40 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.40 mM); Clear solution

*All of the co-solvents are available by MCE.
References

Purity: 98.86%

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Product Name:
Dobutamine hydrochloride
Cat. No.:
HY-15746
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