Dobutamine hydrochloride

Cat. No.: HY-15746 Purity: 98.86%: FAQs
Data Sheet SDS COA Handling Instructions

Dobutamine hydrochloride is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion.

For research use only. We do not sell to patients.

Dobutamine hydrochloride Chemical Structure

CAS No. : 49745-95-1

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solution
10 mM * 1 mL in DMSO	USD 174	In-stock	Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL ready for reconstitution	USD 174	In-stock	Estimated Time of Arrival: December 31
Solid
100 mg	USD 158	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Dobutamine hydrochloride:

Dobutamine Get quote
Dobutamine tartrate Get quote
(rac)-Dobutamine-d₄ hydrochloride Get quote
(rac)-Dobutamine-d₆ hydrochloride Get quote

2 Publications Citing Use of MCE Dobutamine hydrochloride

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α adrenergic receptor β adrenergic receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

α adrenergic receptor

β adrenergic receptor

In Vivo

Dobutamine hydrochloride has a rapid onset of action and a short half-life ^[2].
? Dobutamine hydrochloride (0.15-20 mg/kg; i.p.) results in subsequent increase in the left ventricular function and heart rate acceleration with an increasing dose in wildtype mice^[3].
? Dobutamine hydrochloride results in significant inotropic, lusitropic, and chronotropic cardiac response with a high dose in wildtype mice^[3].
? Low doses of Dobutamine hydrochloride significantly increases inotropic and lusitropic cardiac performance without chronotropic changes in the Tgαq*44 mice^[3].
? Dobutamine hydrochloride increases heart rate only after high doses, but then inotropic and lusitropic cardiac functional reserve is lost^[3].
? Dobutamine hydrochloride increases alveolar liquid clearance in ventilated rats by beta-2 receptor stimulation^[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Tgαq*44 mice (heart failure models)^[3]
Dosage:	0.15 mg/kg, 0.5 mg/kg as a low dose, 1.5 mg/kg, 5 mg/kg, 20 mg/kg as a high dose
Administration:	Intraperitoneal injection
Result:	Induced different response in cardiac function on a low and high dose in mice with with heart failure.

Clinical Trial

Molecular Weight

337.84

Appearance

Solid

Formula

C₁₈H₂₄ClNO₃

CAS No.

49745-95-1

SMILES

OC1=CC=C(CCNC(C)CCC2=CC=C(O)C=C2)C=C1O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : ≥ 33 mg/mL (97.68 mM)

H₂O : 20 mg/mL (59.20 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9600 mL	14.7999 mL	29.5998 mL
5 mM	0.5920 mL	2.9600 mL	5.9200 mL
10 mM	0.2960 mL	1.4800 mL	2.9600 mL

*Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: PBS
Solubility: 16.67 mg/mL (49.34 mM); Clear solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.5 mg/mL (7.40 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (7.40 mM); Clear solution
4.

Add each solvent one by one: 10% DMSO 90% corn oil
Solubility: ≥ 2.5 mg/mL (7.40 mM); Clear solution

*All of the co-solvents are available by MCE.

Purity & Documentation

Purity: 98.86%

Select Batch:

Data Sheet (273 KB) SDS (418 KB)

COA (244 KB) LCMS (126 KB)

Handling Instructions (2659 KB)

References

[1]. Tuttle RR, et al. Dobutamine: development of a new catecholamine to selectively increase cardiac contractility. Circ Res. 1975 Jan;36(1):185-96. [Content Brief]

[2]. Vallet B, et al. Dobutamine: mechanisms of action and use in acute cardiovascular pathology. Ann Cardiol Angeiol (Paris). 1991 Jun;40(6):397-402. [Content Brief]

[3]. Tyrankiewicz U , et al. Characterization of the cardiac response to a low and high dose of dobutamine in the mouse model of dilated cardiomyopathy by MRI in vivo. J Magn Reson Imaging. 2013 Mar;37(3):669-77. [Content Brief]

[4]. Tibayan FA, et al. Dobutamine increases alveolar liquid clearance in ventilated rats by beta-2 receptor stimulation. Am J Respir Crit Care Med. 1997 Aug;156(2 Pt 1):438-44. [Content Brief]