2. Dobutamine

Dobutamine is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine can increase cardiac output and correct hypoperfusion.

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Dobutamine Chemical Structure

Dobutamine Chemical Structure

CAS No. : 34368-04-2

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Dobutamine Related Antibodies

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Description

Dobutamine is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine can increase cardiac output and correct hypoperfusion[1][2][3][4].

In Vivo

Dobutamine has a rapid onset of action and a short half-life [2].
Dobutamine (0.15-20 mg/kg; i.p.) results in subsequent increase in the left ventricular function and heart rate acceleration with an increasing dose in wildtype mice[3].
Dobutamine results in significant inotropic, lusitropic, and chronotropic cardiac response with a high dose in wildtype mice[3].
Low doses of Dobutamine significantly increases inotropic and lusitropic cardiac performance without chronotropic changes in the Tgαq*44 mice[3].
Dobutamine increases heart rate only after high doses, but then inotropic and lusitropic cardiac functional reserve is lost[3].
Dobutamine increases alveolar liquid clearance in ventilated rats by beta-2 receptor stimulation[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Tgαq*44 mice (heart failure models)[3]
Dosage: 0.15 mg/kg, 0.5 mg/kg as a low dose, 1.5 mg/kg, 5 mg/kg, 20 mg/kg as a high dose
Administration: Intraperitoneal injection
Result: Induced different response in cardiac function on a low and high dose in mice with with heart failure.
Clinical Trial
Molecular Weight

301.38

Formula

C18H23NO3
CAS No.
SMILES

OC1=CC=C(CCNC(C)CCC2=CC=C(O)C=C2)C=C1O
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Purity & Documentation
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dobutamine34368-04-2Inhibitorinhibitorinhibit

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