Others

Desmosteryl linoleate is an ester formed by Desmosterol (HY-113224) and Linoleic acid (HY-N0729).

20-Hydroxy-N-arachidonoyl taurine (Compound C20:4 NAT) acts as an activator of TRPV1 and TRPV4, with EC₅₀ values of 28 µM and 21 µM, respectively. 20-Hydroxy-N-arachidonoyl taurine serves as a substrate for fatty acid amide hydrolase (FAAH).

D-myo-Inositol-3,4,5-triphosphate hexasodium is an inositol (HY-B1411) derivative, a subtype-selective IP₃ receptor ligand, with K_d values of 31706 nM, 3019 nM and 11145 nM for rat type 1, type 2 and type 3 receptors, respectively.

2'-Deoxyadenosine-5'-O-diphosphoribose sodium is a TRPM2 agonist. 2'-Deoxyadenosine-5'-O-diphosphoribose sodium enhances calcium-induced currents in inside-out patch-clamp experiments using HEK293 cells expressing human TRPM2. 2'-Deoxyadenosine-5'-O-diphosphoribose sodium is a substrate for Nucleoside Triphosphate Diphosphatase 9 (NUDT9).

IAP ligand-Linker Conjugate 1 is a ligand-linker conjugate targeting IAP, which can be used in the synthesis of PROTAC TEAD1/IAP degrader-1 (HY-181534).

TEAD ligand 3 (compound S20) is a TEAD ligand. As a target protein ligand, TEAD ligand 3 can be used in the synthesis of PROTAC TEAD1/IAP degrader-2 (HY-181537).

TEAD ligand-Linker Conjugate 2 (compound S24) is a conjugate of TEAD‑targeted ligand and linker, which can be used for the synthesis of PROTAC TEAD1/IAP degrader-2 (HY-181537).

TEAD ligand-Linker Conjugate 3 (the blue structure + black structure of A536 in the literature) is a conjugate of a TEAD1-targeting ligand and a linker. TEAD ligand-Linker Conjugate 3 can be coupled with an IAP ligand (HY-181531) to form an IAP-recruiting bifunctional protein degrader (IPD) (HY-181594), also known as a SNIPER degrader. This TEAD SNIPER simultaneously binds to the TEAD1 palmitoylation pocket and the BIR3 domain of cIAP1 to form a ternary complex, efficiently inducing the ubiquitination and degradation of both TEAD1 and cIAP1 (DC₅₀=110 nM, D_max=51%; IC₅₀=122 nM for cIAP1). TEAD ligand-Linker Conjugate 3 and its synthesized SENIPER molecule can be utilized in research on Hippo pathway dysregulation-related diseases, such as NF2-mutant tumors.

DHFR ligand-Linker Conjugate 1 is a Target Protein Ligand-Linker Conjugate that incorporates a ligand and a PROTAC linker, which recruits E3 ligases. DHFR ligand-Linker Conjugate 1 can be used for the synthesis of PROTAC.

EPA Method 533 Isotope Dilution Standard 0.5-2 μg/mL in Methanol:Water is a mixed standard of isotope internal standards.

EPA method 533 isotope performance standard 1-3 mg/mL in methanol:water is a mixed standard of isotope internal standards.

BRD9 ligand-10 is a ligand targeting BRD9. BRD9 ligand-10 can be used as a target protein ligand for the synthesis of PROTAC BRD9 Degrader-10 (HY-181949).

Stable Isotpe-Labeled Amino Acid Mix 1 (20 AA) (U-13C, 97-99%; U-15N, 97-99%) is a stable isotope-labeled amino acid mixture.

dW-CE Phosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.

5'-I-dT-CE Phosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.

5,6-Dihydro-dU-CE phosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.

dX-CE Phosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.

5-Hydroxymethyl-dU-CE phosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.

2-F-dI-CE Phosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.

5-Me-2'-Deoxyzebularine-CE phosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.