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Cat. No.: HY-181949

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PROTAC BRD9 Degrader-10

PROTAC BRD9 Degrader-10 is a PROTAC degrader targeting BRD9, with an IC₅₀ of 2.97 μM against BRD9. PROTAC BRD9 Degrader-10 induces BRD9 degradation via the ubiquitin-proteasome system by recruiting the VHL E3 ubiquitin ligase. PROTAC BRD9 Degrader-10 reduces the viability and inhibits the proliferation of myeloid leukemia cells. PROTAC BRD9 Degrader-10 is applicable for the research of acute myeloid leukemia.
(Pink: BRD9 ligand (HY-181950); Blue: VHL ligand (HY-125845); Black: linker).

For research use only. We do not sell to patients.

Formula: C₅₀H₆₂N₁₀O₇S
Molecular Weight:947.16

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

PROTAC BRD9 Degrader-10 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PROTAC BRD9 Degrader-10 is a PROTAC degrader targeting BRD9, with an IC₅₀ of 2.97 μM against BRD9. PROTAC BRD9 Degrader-10 induces BRD9 degradation via the ubiquitin-proteasome system by recruiting the VHL E3 ubiquitin ligase. PROTAC BRD9 Degrader-10 reduces the viability and inhibits the proliferation of myeloid leukemia cells. PROTAC BRD9 Degrader-10 is applicable for the research of acute myeloid leukemia^[1]. (Pink: BRD9 ligand (HY-181950); Blue: VHL ligand (HY-125845); Black: linker).

IC₅₀ & Target^[1]

BRD9

2.97 μM (IC₅₀)

VHL

All PROTACs Isoforms :

All Epigenetic Reader Domain Isoforms :

In Vitro

PROTAC BRD9 Degrader-10 (compound 2) (1-25 μM; 48 h) induces dose-dependent BRD9 degradation in U937 cells^[1].
PROTAC BRD9 Degrader-10 (1-25 μM; 48 h) suppresses U937 cell viability in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Human acute myeloid leukemia U937 cells
Concentration:

1, 5 ,10, 25 μM
Incubation Time:

48 h
Result:

Induced dose-dependent degradation of BRD9.

Cell Viability Assay^[1]

Cell Line:

Human acute myeloid leukemia U937 cells
Concentration:

1, 5 ,10, 25 μM
Incubation Time:

48 h
Result:

Significantly reduced U937 cell viability at 25 μM and 10 μM.
Maintained viability near control levels at 5 μM and 1 μM.

Chemical Information

Molecular Weight 947.16
Formula C₅₀H₆₂N₁₀O₇S
SMILES

O=C(NC1=CC=CC(NC2=NC3=CC=CC=C3N4C2=NN=C4CC)=C1)CCCCCCOCCOCC(N[C@@H](C(C)(C)C)C(N5[C@H](C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)C[C@@H](O)C5)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Pierri M, et al. Unveiling New Triazoloquinoxaline-Based PROTACs Designed for the Selective Degradation of the ncBAF Chromatin Remodeling Subunit BRD9. Chemistry. 2025;31(34):e202404218. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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PROTAC BRD9 Degrader-10

All PROTACs Isoforms

All Epigenetic Reader Domain Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PROTAC BRD9 Degrader-10 Related Classifications

HY-181949 Related Classifications