2. PROTAC Epigenetics
  3. PROTACs Epigenetic Reader Domain
  4. PROTAC BRD9 Degrader-10

PROTAC BRD9 Degrader-10 is a PROTAC degrader targeting BRD9, with an IC50 of 2.97 μM against BRD9. PROTAC BRD9 Degrader-10 induces BRD9 degradation via the ubiquitin-proteasome system by recruiting the VHL E3 ubiquitin ligase. PROTAC BRD9 Degrader-10 reduces the viability and inhibits the proliferation of myeloid leukemia cells. PROTAC BRD9 Degrader-10 is applicable for the research of acute myeloid leukemia.
(Pink: BRD9 ligand (HY-181950); Blue: VHL ligand (HY-125845); Black: linker).

For research use only. We do not sell to patients.

PROTAC BRD9 Degrader-10

PROTAC BRD9 Degrader-10 Chemical Structure

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PROTAC BRD9 Degrader-10 Related Antibodies

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Description

PROTAC BRD9 Degrader-10 is a PROTAC degrader targeting BRD9, with an IC50 of 2.97 μM against BRD9. PROTAC BRD9 Degrader-10 induces BRD9 degradation via the ubiquitin-proteasome system by recruiting the VHL E3 ubiquitin ligase. PROTAC BRD9 Degrader-10 reduces the viability and inhibits the proliferation of myeloid leukemia cells. PROTAC BRD9 Degrader-10 is applicable for the research of acute myeloid leukemia[1]. (Pink: BRD9 ligand (HY-181950); Blue: VHL ligand (HY-125845); Black: linker).

IC50 & Target[1]

BRD9

2.97 μM (IC50)

VHL

 

In Vitro

PROTAC BRD9 Degrader-10 (compound 2) (1-25 μM; 48 h) induces dose-dependent BRD9 degradation in U937 cells[1].
PROTAC BRD9 Degrader-10 (1-25 μM; 48 h) suppresses U937 cell viability in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC BRD9 Degrader-10 Related Antibodies

Western Blot Analysis[1]

Cell Line: Human acute myeloid leukemia U937 cells
Concentration: 1, 5 ,10, 25 μM
Incubation Time: 48 h
Result: Induced dose-dependent degradation of BRD9.

Cell Viability Assay[1]

Cell Line: Human acute myeloid leukemia U937 cells
Concentration: 1, 5 ,10, 25 μM
Incubation Time: 48 h
Result: Significantly reduced U937 cell viability at 25 μM and 10 μM.
Maintained viability near control levels at 5 μM and 1 μM.
Molecular Weight

947.16

Formula

C50H62N10O7S
SMILES

O=C(NC1=CC=CC(NC2=NC3=CC=CC=C3N4C2=NN=C4CC)=C1)CCCCCCOCCOCC(N[C@@H](C(C)(C)C)C(N5[C@H](C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)C[C@@H](O)C5)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC BRD9 Degrader-10 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC BRD9 Degrader-10PROTACsEpigenetic Reader DomainVHL E3 ubiquitin ligaseBRD9myeloid leukemia cellsU937 cellsacute myeloid leukemiaubiquitin-proteasome systemInhibitorinhibitorinhibit

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PROTAC BRD9 Degrader-10
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HY-181949
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