Adrenergic Receptor
Beta Receptor
Adrenergic receptors are a class of G protein-coupled receptors that are targets of the catecholamines, especially norepinephrine and epinephrine. Many cells possess these receptors, and the binding of a catecholamine to the receptor will generally stimulate the sympathetic nervous system. The sympathetic nervous system is responsible for the fight-or-flight response, which includes widening the pupils of the eye, mobilizing energy, and diverting blood flow from non-essential organs to skeletal muscle. There are two main groups of adrenergic receptors, α and β, with several subtypes. α receptors have the subtypes α1 and α2. β receptors have the subtypes β1, β2 and β3. All three are linked to Gs proteins, which in turn are linked to adenylate cyclase. Agonist binding thus causes a rise in the intracellular concentration of the second messenger cAMP. Downstream effectors of cAMP include cAMP-dependent protein kinase (PKA), which mediates some of the intracellular events following hormone binding.
Adrenergic Receptor Isoform Specific Products
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Adrenergic Receptor Inhibitors
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Adrenergic Receptor Agonists
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Adrenergic Receptor Antagonists
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Adrenergic Receptor Activators
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Adrenergic Receptor Modulators
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Adrenergic Receptor Degrader
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Adrenergic Receptor Controls
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Adrenergic Receptor Substrates
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Adrenergic Receptor Ligands
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Adrenergic Receptor Related Products (1622)
Related Products (1622)
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Antibodies (4)
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Adrenergic Receptor Isoform Comparison
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Atomoxetine-d3 hydrochloride
0 ImagesCat. No.: HY-110223CAS No.: 1217776-38-9Atomoxetine-d3 hydrochloride is the deuterium labeled Atomoxetine hydrochloride. Atomoxetine hydrochloride is a potent and selective noradrenalin re-uptake inhibitor (Ki values are 5, 77 and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively).
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Alfuzosin-d3 hydrochloride
0 ImagesCat. No.: HY-B0192ASCAS No.: 1216383-97-9Synonyms: SL 77499-10-d3Alfuzosin-d3 hydrochloride is the deuterium labeled Alfuzosin hydrochloride. Alfuzosin hydrochloride is an α1 adrenergic receptor antagonist used to treat benign prostatic hyperplasia (BPH).
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(R)-Metoprolol-d7
0 ImagesCat. No.: HY-17503S1CAS No.: 1292907-84-6(R)-Metoprolol-d7 is the deuterium labeled Metoprolol. Metoprolol (Toprol) is a selective β1 receptor blocker used in treatment of several diseases of the cardiovascular system, especially hypertension[1][2].
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Nomifensine-d3 maleate
0 ImagesCat. No.: HY-B1110SCAS No.: 1795140-41-8Synonyms: (±)-Nomifensine-d3 maleate; Nomifensin-d3 maleateNomifensine-d3 ((±)-Nomifensine-d3) maleate is the deuterium labeled Nomifensine maleate (HY-B1110A). Nomifensine ((±)-Nomifensine) maleate is a potent norepinephrine (NE) and dopamine (DA) reuptake inhibitor. Nomifensine maleate inhibits uptake of NE, DA and 5-HT in rat brain synaptosomes, with IC50 values of 6.6 nM, 48 nM and 830 nM, and Ki values of 4.7 nM, 26 nM and 4000 nM, respectively. Nomifensine maleate has antidepressant and analgesic effects. Nomifensine maleate is used in neurodegenerative diseases, compound addiction, and pain research.
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Diclofensine-d3 (hydrochloride)
0 ImagesCat. No.: HY-18610SCAS No.: 1794780-41-8Diclofensine-d3 (Ro-8-4650-d3) hydrochloride is the deuterium labeled Diclofensine hydrochloride. Diclofensine hydrochloride is an orally active neuronal monoamine uptake inhibitor. Diclofensine hydrochloride blocks the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 values of 0.74, 2.3 and 3.7 nM, respectively. Diclofensine hydrochloride potentiates norepinephrine-induced hypertension and attenuates Tyramine (HY-W007606)-induced hypertension. Diclofensine hydrochloride produces psychostimulant and mood-elevating effects without causing sudden disappearance or withdrawal reactions. Diclofensine hydrochloride can be used in the research of moderate to severe depression.
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Prazobind-d8
0 ImagesCat. No.: HY-118335SCAS No.: 1189701-23-2Synonyms: SZL 49-d8Prazobind-d8 (SZL 49-d8) is the deuterium labeled Prazobind (HY-118335). Prazobind, a prazosin analog, is an irreversible α1-adrenoceptor antagonist. Prazobind competes for alpha 1-adrenoceptor binding sites with a similar potency (IC50 of 1 nM) in tissues enriched in both the alpha 1A (hippocampus) and alpha 1B (liver) subtypes. Prazobind partially inhibits the contractions of circular muscles, longitudinal muscles and smooth muscles of the spleen. Prazobind can be used for the study of blood pressure.
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Clonidine-d4 hydrochloride
0 ImagesCat. No.: HY-12721SCAS No.: 67151-02-4Clonidine-d4 (hydrochloride) is the deuterium labeled Clonidine. Clonidine hydrochloride is an alpha 2-adrenergic agonist.
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Medetomidine-d3 hydrochloride
0 ImagesCat. No.: HY-17034BSCAS No.: 1246820-20-1Synonyms: MPV785-d3Medetomidine-d3 (hydrochloride) is the deuterium labeled Medetomidine hydrochloride. Medetomidine hydrochloride is an agonist of adrenergic alpha-2 receptor.
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(Rac)-Tamsulosin-d3 hydrochloride
0 ImagesCat. No.: HY-B0661CSCAS No.: 1189923-88-3(Rac)-Tamsulosin-d3 hydrochloride is the deuterated-labeled Tamsolusin hydrochloride (HY-B0661C). Tamsolusin hydrochloride (YM12617 hydrochloride; LY253351 hydrochloride) is an isomer of Tamsulosin (HY-B0661). Tamsolusin hydrochloride is a sulfonamide phenethylamine derivative and a competitive antagonist of selective post-synaptic α1-adrenoceptors. Tamsolusin hydrochloride inhibits CYP3A4 activity in a non-competitive, enantiomer-specific manner, with an IC50 and Ki of 6.75 μM. Tamsolusin hydrochloride produces dose-dependent hypotension, preferentially antagonizing α1-adrenoceptor-mediated pressor responses, and inhibits α2-adrenoceptor-mediated pressor responses at high doses. Tamsolusin hydrochloride can be used in research related to various diseases such as metabolism.
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Terbutaline-d9
0 ImagesCat. No.: HY-B0802ASCAS No.: 1189658-09-0Terbutaline-d9 is the deuterium labeled Terbutaline.
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Carteolol-d9 hydrochloride
0 ImagesCat. No.: HY-17495ASCAS No.: 1346602-13-8Synonyms: OPC-1085-d9 hydrochlorideCarteolol-d9 (hydrochloride) is the deuterium labeled Carteolol hydrochloride. Carteolol hydrochloride (OPC-1085 hydrochloride) is a non-selective beta blocker used to treat glaucoma.
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Indacaterol-d3
0 ImagesCat. No.: HY-14299SCAS No.: 2699828-16-3Indacaterol-d3 is deuterium labeled Indacaterol.
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Azepexole
0 ImagesCat. No.: HY-103212BCAS No.: 36067-73-9Synonyms: B-HT 933Azepexole (B-HT 933) is a selective α2 adrenergic inducer with over 300-fold selectivity for α2 adrenergic receptors over α1 adrenergic receptors. Azepexole can be used to study the biological functions of α2 adrenergic receptors and inhibition of related diseases. Azepexole may also play a role in regulating mood and improving cognitive function.
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Naftopidil-d5
0 ImagesCat. No.: HY-B0391S1CAS No.: 2747918-58-5Synonyms: KT-611-d5; BM-15275-d5Naftopidil-d5 is deuterium labeled Naftopidil. Naftopidil (KT-611) is is a selective alpha1-adrenoceptor antagonist, with Kis of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-, α1b- and α1d-adrenoceptor subtypes, respectively. Naftopidil has antiproliferative effects. Naftopidil can be used for the research of prostate hyperplasia.
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Solabegron hydrochloride
0 ImagesCat. No.: HY-19436ACAS No.: 451470-34-1Synonyms: GW 427353BSolabegron hydrochloride is a selective β3-adrenergic receptor agonist, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR, with an EC50 value of 22 nM. Solabegron hydrochloride (GW 427353) is being developed for the treatment of overactive bladder and irritable bowel syndrome.
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Norfenefrine hydrochloride (Standard)
0 ImagesNorfenefrine (hydrochloride) (Standard) is the analytical standard of Norfenefrine (hydrochloride). This product is intended for research and analytical applications. Norfenefrine hydrochloride is an orally active, endogenously found α-adrenergic agonist and can be used for the research of female stress incontinence.
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Procaterol-d7 hydrochloride
0 ImagesCat. No.: HY-114732SProcaterol-d7 hydrochloride is the deuterium labeled Procaterol hydrochloride (HY-100704). Procaterol is an oral selective β2 adrenergic receptor agonist. Procaterol inhibits eosinophil migration and the release of eosinophil chemotactic factor from BEAS-2B cells through a cyclic AMP-dependent mechanism. Procaterol has a large dose difference existing between the bronchodilator effect and the anabolic effect in rat, can be used for asthma research in athletes.
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Mivazerol
0 ImagesCat. No.: HY-106865CAS No.: 125472-02-8Mivazerol is a selective α2-adrenoceptor agonist. Mivazerol decreases the spontaneous release of serotonin (5-HT) and significantly inhibits the immobilization stress-induced enhancement of norepinephrine (NE), dopamine (DA) and dihydroxyphenylacetic acid (DOPAC). Mivazerol inhibits intrathecal release of glutamate evoked by halothane withdrawal in rats, and exerts neuroprotective effects in forebrain ischemia rats. Mivazerol can be used for myocardial ischemia research.
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Fenmetozole
0 ImagesCat. No.: HY-105960CAS No.: 41473-09-0Fenmetozole is an antagonist of ethanol, and also antagonizes α2-adrenergic receptor, which has antidepressant effect.
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Clebopride malate (Standard)
0 ImagesClebopride malate (Standard) is the analytical standard of Clebopride malate (HY-B1613A). This product is intended for research and analytical applications. Clebopride malate is an orally active dopamine Receptor antagonist. Clebopride malate acts on dopamine D2 receptors and has antiemetic and prokinetic effects. Clebopride malate can be used in the study of functional gastrointestinal disorders.
