Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.
Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
All Product Categories
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Fungal Related Products (2720)
Related Products (2720)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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Calcimycin (Standard)
0 ImagesCat. No.: HY-N6687RCAS No.: 52665-69-7Synonyms: A-23187 (Standard); Antibiotic A-23187 (Standard)Calcimycin (Standard) is the analytical standard of Calcimycin. This product is used for research and analytical applications. Calcimycin is an antibiotic and a unique divalent cation ionophore, such as calcium ions and magnesium ions. Calcimycin induces Ca2+ -dependent cell death by increasing the intracellular calcium concentration. Calcimycin inhibits the growth of Gram-positive bacteria and some fungi, and also inhibits the activity of ATPase and uncouples the oxidative phosphorylation (OXPHOS) of mammalian cells, inducing apoptosis and autophagy.
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SDH-IN-11
0 ImagesCat. No.: HY-157459CAS No.: 2998946-58-8SDH-IN-11 (compound A7) is a SDH inhibitor, and shows inhibitory effect on nematode feeding, reproductive ability, and egg hatching. SDH-IN-11 promotes the oxidative stress of nematodes and causes intestinal damage to nematodes. SDH-IN-11 inhibits the activity of succinate dehydrogenase (SDH) in nematodes.
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Cytovaricin
0 ImagesCat. No.: HY-N14179CAS No.: 79553-45-0Cytovaricin has the activity of inhibiting Yoshida sarcoma cells and has weak anti-phytopathogenic fungi and chlorella activity.
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Eremofortin B
0 ImagesCat. No.: HY-126484CAS No.: 60048-73-9Eremofortin B is a sesquiterpenoid compound synthesized by penicillium roqueforti PR Toxin (PRT).
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Gladiolic acid
0 ImagesGladiolic acid has the antifungal activity of Absidia glauca Hagem, garlic spores, Byssochlamys fulva, Trichophyton mentagrophytes, Corpuscular falciparum.
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Polyoxin F
0 ImagesCat. No.: HY-N14211CAS No.: 23116-76-9Polyoxin F is a nucleoside antifungal antibiotic and has significant effects on rice sheath blight.
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Antifungal agent 145
0 ImagesCat. No.: HY-180672Antifungal agent 145 (Compound 14') is a highly effective fungicide. Antifungal agent 145 exhibits MICs against Candida albicans, Candida tropicalis, and Cryptococcus neoformans of 4, 8, and 8 μg/mL respectively. Antifungal agent 145 exerts a potent and rapid bactericidal effect by disrupting the fungal cell membrane, and can effectively inhibit and destroy biofilms. Antifungal agent 145 has improved safety and can be used in antifungal research.
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Ketoconazole carbonyl-13C
0 ImagesCat. No.: HY-166670SSynonyms: Ketoconazol-13C; R 41400-13CKetoconazole carbonyl-13C (Ketoconazol-13C) is 13C labeled Ketoconazole. Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.
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Nidulin
0 ImagesCat. No.: HY-135422CAS No.: 10089-10-8Synonyms: MethylustinNidulin (Methylustin) is a depsidone isolated from a marine fungus Aspergillus unguis. Nidulin shows antifungal and antibacterial against pathogenetic strains, Pseudomonas aeruginosa, Methicillin-resistant Staphylococcus aureus and Candida albicans with inhibition zones of 9.5 mm, 9.0 mm and 9.0 mm, respectively. Nidulin exhibits potent larvicidality against brine shrimp.
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Eupenoxide
0 ImagesCat. No.: HY-N15024CAS No.: 89773-19-3Eupenoxide is an antibiotic with antifungal activity that can be found by fungi of the genus Eupenicillium.
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Cyclosporin L
0 ImagesCat. No.: HY-N9754CAS No.: 108027-39-0Cyclosporin L is a cyclosporin that can be found in Tolypocladium inflatum, with moderate immunosuppressive and antifungal activities.
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2,6-Dibromophenol (Standard)
0 Images2,6-Dibromophenol (2,6-DBP) is a weak inhibitor targeting voltage-gated Ca2+ channels. 2,6-Dibromophenol has no significant effect on potassium-induced calcium elevation in PC12 cells. 2,6-Dibromophenol shows a 48 h EC50 of 2.78 mg/L for Daphnia magna and a 96 h EC50 of 9.90 mg/L for algae (Scenedesmus quadricauda).
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Pseudolaric Acid C (Standard)
0 ImagesCat. No.: HY-N0672RCAS No.: 82601-41-0Pseudolaric Acid C (Standard) is the analytical standard of Pseudolaric Acid C. This product is intended for research and analytical applications. Pseudolaric C is a diterpenoid isolated from the root bark of Pseudolarix amabilis, has antifungal activity.
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Erigeside II
0 ImagesCat. No.: HY-N10318CAS No.: 100187-70-0Synonyms: Dictamnoside AErigeside II is a sesquiterpene glycoside found in the root bark of Dictamnus dasycarpus. Erigeside II stimulates the proliferation of T-cells.
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2-Chloro-N-(2-methyl-4-bromophenyl)acetamide
0 ImagesCat. No.: HY-101424CAS No.: 96686-51-02-Chloro-N-(2-methyl-4-bromophenyl)acetamide is an antifungal compound.
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CYP51-IN-30
0 ImagesCat. No.: HY-179270CAS No.: 108590-84-7
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Hancockiamide B
0 ImagesCat. No.: HY-182489CAS No.: 2758265-35-7Hancockiamide B (Compound 2) is a piperazine alkaloid. Hancockiamide B is isolated from the fungus Aspergillus hancockii.
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Nuarimol
0 ImagesCat. No.: HY-W714300CAS No.: 63284-71-9Nuarimol is a fungicide used for plant protection in agriculture. Nuarimol is a phenobarbital-type inducer of hepatic drug-metabolizing enzymes. It triggers transient but robust regenerative hepatocyte proliferation accompanied by hepatomegaly by causing reversible hepatocellular injury.
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Appenolide A
0 ImagesCat. No.: HY-125487CAS No.: 148077-10-5Appenolide A is an antifungal furanones that can be isolated from the coprophilous fungus Podospora appendiculata.
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β-Prumycin hydrochloride
0 ImagesCat. No.: HY-N14912CAS No.: 54612-74-7β-Prumycin hydrochloride is a carbohydrate antibiotic. β-Prumycin hydrochloride has anti-fungal activity and weak anti-individual bacterial activity.
