Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.
Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
All Product Categories
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Fungal Related Products (2735)
Related Products (2735)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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Triclosan (Standard)
0 ImagesTriclosan (Standard) is the analytical standard of Triclosan. This product is intended for research and analytical applications. Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC50s of 2 µM and 10 µM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models.
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Dermostatin B
0 ImagesCat. No.: HY-N14980CAS No.: 51141-40-3Dermostatin B is a polyene antibiotic with antifungal activity that can be used in the study of fungal infections.
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Lawsone methyl ether (Standard)
0 ImagesLawsone methyl ether (Standard) (2-Methoxy-1,4-naphthoquinone (Standard)) is the analytical standard of Lawsone methyl ether (HY-N7116). This product is intended for research and analytical applications. Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone), isolated from Impatiens balsamina L. and Swertia calycina, exhibits potent antifungal and antibacterial activities.
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Myosin-5-IN-2
0 ImagesCat. No.: HY-175647Myosin-5-IN-2 (Compound G19) is a Myosin-5 inhibitor. Myosin-5-IN-2 has an antifungal activity against Fusarium graminearum (Fg), Botrytis cinerea and Rhizoctonia solani with an EC50 s of 0.326 μg/mL for Fg. Myosin-5-IN-2 has effective protective and curative control efficiency for wheat leaves. Myosin-5-IN-2 severely damages the surface integrity of mycelial cells and induces cytoplasmic leakage. Myosin-5-IN-2 can be used for fungal infections like fusarium head blight (FHB) research.
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Fmoc-Pro-OH-13C5,15N
0 ImagesCat. No.: HY-W013780S1CAS No.: 1217452-48-6Fmoc-Pro-OH-13C5,15N is a 15N-labeled and 13C-labled Fmoc-Pro-OH (HY-W013780). Fmoc-Pro-OH is a proline derivative.
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(9Z)-9,17-Octadecadiene-12,14-diyne-1,11,16-triol
0 ImagesCat. No.: HY-N2789CAS No.: 211238-60-7(9Z)-9,17-Octadecadiene-12,14-diyne-1,11,16-triol is a nature product that could be isolated from the ethyl acetate extract of Cassonia barteri (Araliaceae) leaves. (9Z)-9,17-Octadecadiene-12,14-diyne-1,11,16-triol has antibacterial activity against Bacillus subtilis and Pseudomonas fluorescens, antifungal activity against Cladosporium cucumerinum, moiluscicidal activity against Biomphalaria glabrata. (9Z)-9,17-Octadecadiene-12,14-diyne-1,11,16-triol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Pyrifenox
0 ImagesCat. No.: HY-123002CAS No.: 88283-41-4Pyrifenox is a fungicide, which is used in fruits, ornamentals, and vegetables. Pyrifenox can be utilized as one of the assessment criteria for environmental and food safety.
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SDH-IN-45
0 ImagesCat. No.: HY-181610CAS No.: 3112883-32-3SDH-IN-45 is a succinate dehydrogenase BcSDH inhibitor and mycelial growth inhibitor targeting Botrytis cinerea, with an IC50 of 5.97 μg/mL against Botrytis cinerea. SDH-IN-45 inhibits succinate dehydrogenase, a component of the mitochondrial electron transport chain, via a unique binding mode, thereby regulating fungal energy metabolism. SDH-IN-45 causes morphological damage to Botrytis cinerea mycelia, leading to collapse and shrinkage of mycelial structures. SDH-IN-45 exhibits in vitro fungicidal activity against Botrytis cinerea. SDH-IN-45 can be used in research related to cucumber gray mold.
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Antifungal agent 128
0 ImagesCat. No.: HY-173206Antifungal agent 128 (Compound 3ja) is an antifungal agent. When used in combination with Fluconazole (HY-B0101), the MIC range against C. albicans strains is 0.5-4 μg/mL. Antifungal agent 128 can be used in the research of the anti-infection field.
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TMV-IN-15
0 ImagesCat. No.: HY-180272CAS No.: 2712178-59-9MV-IN-15 (compound 4AF) is a potent antiviral and antifungal agent. TMV-IN-15 suppresses viral particle assembly by binding to the TMV-CP, inducing prominent aggregation and structural fusion. TMV-IN-15 exhibits inhibitory activity against Physalospora piricola and Rhizoctonia cereal. TMV-IN-15 can be used for pesticides research.
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Antifungal agent 156
0 ImagesCat. No.: HY-185177CAS No.: 2446126-42-5Antifungal agent 156 (Ex.1-123) is a heterocyclic pyridazine compound and a phytopathogenic fungal control agent, which can be used in studies related to phytopathogenic fungal infection.
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Triticonazole
0 ImagesCat. No.: HY-B2058CAS No.: 131983-72-7Triticonazole is an orally active triazole fungicide and androgen receptor antagonist. Triticonazole inhibits testosterone-induced androgen receptor activation and reduces basal testosterone secretion. Prenatal exposure to Triticonazole causes shortened anogenital distance in male rat fetuses and induces organ-specific histopathological changes in pigs. Triticonazole can be used for detoxification of seeds contaminated with fungal pathogens, but there is a risk of animal poisoning if the treated seeds are used as animal feed.
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SDH-IN-38
0 ImagesCat. No.: HY-178778CAS No.: 3066787-57-0SDH-IN-38 (Compound IIIe) is a Succinate dehydrogenase inhibitor. SDH-IN-38 is an antifungal agent, with an EC50 value of 0.009 μg/mL against R. solani mycelia. SDH-IN-38 inhibits mycelial growth by affecting mycelial respiration. SDH-IN-38 induces cellular senescenc and reduces mitochondrial membrane potential in mycelia.
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(E)-Fagaramide
0 ImagesCat. No.: HY-W989530CAS No.: 495-86-3(E)-Fagaramide is an amide and antifungal agent, can be found in the seeds and leaves of Piper tuberculatum, and inhibits growth of Cladosporium cladosporioides. (E)-Fagaramide can be used for the research of fungal infection (C. cladosporioides).
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Antimicrobial agent-40
0 ImagesCat. No.: HY-173528Antimicrobial agent-40 (Compound 5a) has antimicrobial activity against fungi, Gram-negative and Gram-positive bacteria. Antimicrobial agent-40 has good cytotoxicity against MCF-7 cells (IC50: 33.52 μM) and exhibits anticancer activity.
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9-Hydroxyoudemansin A
0 ImagesCat. No.: HY-N15042CAS No.: 225937-85-99-Hydroxyoudemansin A is an antibiotic. 9-Hydroxyoudemansin A has antifungal activity, has an MIC of 12.5 μg/mL against ochre-like yeast, and is resistant to fungi such as Candida albicans, Crimson Yeast, Penicillium and Streptomyces with MICs are all> 50 μg/mL. No anti-bacterial effect.
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Pyribencarb (Standard)
0 ImagesPyribencarb (Standard) is the analytical standard of Pyribencarb. This product is intended for research and analytical applications. Pyribencarb is a benzylcarbamate-type fungicide, which is active against a wide range of plant pathogenic fungi. Pyribencarb is a potent Qo inhibitor of cytochrome b. Pyribencarb is especially active against Botrytis cinerea and Sclerotinia sclerotirum.
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Ezomycin B2
0 ImagesCat. No.: HY-N14282CAS No.: 57973-16-7Ezomycin B2 is an antibiotic with antifungal activity.
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Nannochelin C
0 ImagesCat. No.: HY-125362CAS No.: 133705-26-7Nannochelin C is a citrate-hydroxamate siderophore and iron chelator found in Nannocystis exedens strain Na e485. The MIC of Nannochelin C against Brevibacterium ammoniagenes is 0.39 μg/mL, and it exhibits weak growth inhibitory activity against some Gram-positive bacteria. The antimicrobial effect of Nannochelin C may be associated with its metal chelating activity. Nannochelin C can be used in studies related to siderophores, microbial iron metabolism and antimicrobial activity.
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SMTP-0
0 ImagesCat. No.: HY-N16672CAS No.: 951393-54-7Synonyms: ent-Stachybotrin BSMTP-0 (ent-Stachybotrin B) is an enantiomer of Stachybotrin B isolated from Stachybotrys microspora. SMTP-0 is the simple homologues of the SMTP nonlysine-analog plasminogen modulator family but shows no plasminogen modulator activity. SMTP-0 exhibits antibacterial and antifungal effects. SMTP-0 can be used for the research of infection.
