Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.
Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
All Product Categories
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Fungal Related Products (2716)
Related Products (2716)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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Sambutoxin
0 ImagesCat. No.: HY-N1320CAS No.: 160047-56-3Sambutoxin is a mycotoxin. Sambutoxin can be isolated from wheat culture of Fusarium sambucinum.
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Cephemimycin
0 ImagesCat. No.: HY-N14788CAS No.: 34279-51-1Cephemimycin has weak antibacterial and antifungal activity.
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Tetrahydroechinocandin B
0 ImagesCat. No.: HY-135141CAS No.: 54651-06-8Synonyms: L-687901Tetrahydroechinocandin B (L 687,901) is a potent antifungal agent. Tetrahydroechinocandin B inhibits 1,3-beta-D-glucan synthesis with an IC50 of 0.85 μg/mL.
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(-)-Maackiain (Standard)
0 Images(-)-Maackiain (Standard) is the analytical standard of (-)-Maackiain. This product is intended for research and analytical applications. (-)-Maackiain is a pterocarpan phytoalexin produced from Sophora flavescens. (-)-Maackiain is toxic to several genera of fungal pathogens of legume and non legume hosts. (-)-Maackiain enhances the activation of NLRP3 inflammasome, inhibits the activation of NF-κB pathway, exhibiting thereby immunostimulatory and anti-inflammatory activities. (-)-Maackiain is orally active.
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Crocacin B
0 ImagesCat. No.: HY-N14040CAS No.: 237425-37-5Crocacin B has anti-yeast and filamentous fungal activity. Crocacin B can inhibit mouse fibroblasts L929. In the microsomes of the calf's heart, Crocacin B can interrupt the bc1 segment of electronic transmission, causes redshift of 569 nm peak in cytochrome B reduction spectrum.
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Oudemansin A
0 ImagesCat. No.: HY-165494CAS No.: 73341-71-6Oudemansin A is an antibiotic. Oudemansin A acts on fungi to inhibit protein, RNA and DNA synthesis.
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Phenothiazine (Standard)
0 ImagesPhenothiazine (Standard) is the analytical standard of Phenothiazine. This product is intended for research and analytical applications. Phenothiazine is an antibiotic which has insecticidal, fungicidal, antibacterial and anthelmintic activities. Phenothiazine also can be used for the research of neurological diseases.
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Terconazole (Standard)
0 ImagesSynonyms: R42470 (Standard)Terconazole (Standard) is the analytical standard of Terconazole. This product is intended for research and analytical applications. Terconazole is a broad-spectrum antifungal medication for the treatment of vaginal yeast infection.
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Scorodonin
0 ImagesCat. No.: HY-N13915CAS No.: 74660-77-8Scorodonin has anti-bacterial, Streptomyces and fungal effects. Scorodonin inhibits DNA-dependent RNA polymerases with an IC50 of 25 μg/mL.
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Neoenactin M2
0 ImagesCat. No.: HY-N14824CAS No.: 108334-69-6Neoenactin M2 has strong anti-yeastlike and filamentous fungal effects.
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Sequoiaflavone
0 ImagesCat. No.: HY-119416CAS No.: 21763-71-3Sequoiaflavone is a biflavonoid compound with multiple activities. Sequoiaflavone suppresses hepatic CYP1A1/(7-Ethoxycoumarin O-deethylase) ECOD, prevents Aβ1-42 fibrillization (IC50 = 0.29 μM) and disaggregates amyloid fibrils (EC50 = 2.04 μM), inhibits Alternaria alternata and inhibits human recombinant PDE5A1 overexpressed in COS-7 cells (IC50 = 19.9 μM) to exert NO-independent vasodilation. Sequoiaflavone can be used in Alzheimer's disease, peripheral circulatory disorder, and antifungal research.
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Pseudolaric acid A-O-β-D-glucopyranoside (Standard)
0 ImagesCat. No.: HY-N4088RCAS No.: 98891-44-2Pseudolaric acid A-O-β-D-glucopyranoside (Standard) is the analytical standard of Pseudolaric acid A-O-β-D-glucopyranoside. This product is intended for research and analytical applications. Pseudolaric acid A-O-β-D-glucopyranoside, isolated from Cortex Pseudolaricis, demonstrates antifungal and antifertility activities.
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IKD-8344
0 ImagesCat. No.: HY-N8280CAS No.: 129046-69-1IKD-8344 is a macrocyclic dilactone originally isolated from an actinomycete species and has diverse biological activities, including anticancer, antimicrobial, and anthelmintic properties. It is cytotoxic to L5178Y murine leukemia cells (IC50=0.54 ng/ml).1 IKD-8344 inhibits growth of the mycelial form of C. albicans (MIC=6.25 μg/mL) and potentiates the activity of polymyxin B against the multidrug-resistant pathogenic bacterium B. cenocepacia.
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CYP51-IN-22
0 ImagesCat. No.: HY-174353CYP51-IN-22, the non-deuterated analog of CYP51-IN-23-d3 (HY-174353S), is a potent and broad-spectrum CYP51 inhibitor.CYP51-IN-22 inhibits Aspergillus fumigatum with a MIC80 of 1 μg/mL. CYP51-IN-22 can prevent fungal phase transformation and biofilm formation. CYP51-IN-22 exhibits anti-drug resistance activity and fungal activity, and shows excellent safety for cells and significant pharmacological activity in mice. CYP51-IN-22 can be used for the study of invasive fungal infections (IFIs).
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Zinniol
0 ImagesCat. No.: HY-N9573CAS No.: 17811-28-8Zinniol is a penta-substituted benzene phytotoxin that can be produced by a variety of phytopathogenic fungi. Zinniol can be detected in sunflower tissues in the early stage of infection and may be involved in the occurrence of sunflower diseases.
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Darlucin B
0 ImagesCat. No.: HY-N14151CAS No.: 162341-16-4Darlucin B has antibacterial and fungi activity, and weak cytotoxicity.
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Tolclofos-methyl (Standard)
0 ImagesTolclofos-methyl (Standard) is the analytical standard of Tolclofos-methyl (HY-B2053). This product is intended for research and analytical applications. Tolclofos-methyl is an organophosphorus fungicide. Tolclofos-methyl undergoes photoinduced oxidative degradation to form oxo-analog derivatives. Tolclofos-methyl inhibits spore division in fungi and oomycetes, induces cytoplasmic leakage, and interferes with flagellar movement. Tolclofos-methyl is rapidly metabolized and excreted in rodents. Tolclofos-methyl can be used in studies related to fungal infections.
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De-N-methylpamamycin-593B
0 ImagesCat. No.: HY-N14730CAS No.: 226722-70-9De-N-methylpamamycin-593B is a 16-membered ring macrocyclic dilactone. De-N-methylpamamycin-593B has Aerial Mycelium-inducing activity.
