Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.
Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
All Product Categories
-
Fungal Related Products (2718)
Related Products (2718)
-
Antibodies (1)
-
Related Compound Screening Libraries (1)
-
Dihydrobiochanin A
0 ImagesCat. No.: HY-169812CAS No.: 83920-62-1Dihydrobiochanin A has antifungal activity. Dihydrobiochanin A is a flavonoid that can isolated from Swartzia polyphylla.
-
Laccase-IN-5
0 ImagesCat. No.: HY-170378Laccase-IN-5 (Compound 2b) is the inhibitor for Laccase with an IC50 of 0.82 μM. Laccase-IN-5 increases the cell membrane permeability, limits the growth of hyphae, destorys the cell wall, and induces oxidative stress responses. Laccase-IN-5 exhibits antifungal activity against various plant pathogenic fungi and oomycetes, inhibits B. dothidea with an EC50 of 0.96 mg/L.
-
SM-4470
0 ImagesCat. No.: HY-129585CAS No.: 89433-57-8SM-4470 is an orally active antifungal compound. SM-4470 has inhibitory activity against yeast, Aspergillus, and dermatophytes in vitro.
-
Mepronil (Standard)
0 ImagesCat. No.: HY-124408RCAS No.: 55814-41-0Mepronil (Standard) is the analytical standard of Mepronil. This product is intended for research and analytical applications. Mepronil, a compound belonging to the carboxyamine group of fungicides, has a particularly strong bactericidal effect on basidiomycete fungi. Mepronil acts as a single point inhibitor of the succinate ubiquinone reductase or succinate dehydrogenase complex. Mepronil can be used in the study of cross resistance and biological infection.
-
Crotocin
0 ImagesCat. No.: HY-N14547CAS No.: 21284-11-7Crotocin has the fungal activity of anti-cryptococcus neoforme, candida albicans, Tinea trichoderma of brewer's yeast, and can be inactivated by blood.
-
Gymnoascolide A
0 ImagesCat. No.: HY-N15186CAS No.: 865092-05-3Gymnoascolide A, identified as a fungal metabolite in M. filamentosa, demonstrates vasodilatory effects. At a concentration of 1 µM, it effectively inhibits contractions induced by calcium in isolated rat aortic rings.
-
Enactin Ⅴa
0 ImagesCat. No.: HY-N14219CAS No.: 130640-31-2Enactin Va is found in the strain of Streptomyces roseoviridis. Enactin Va has only weak antifungal activity.
-
Antifungal agent 141
0 ImagesCat. No.: HY-179704Antifungal agent 141, a Phenoxazine (HY-34463) derivative, is an antifungal agent. Antifungal agent shows potent antifungal activity in Cryptococcus neoformans and Candida albicans with MIC values of 2 and 4 µg/mL. Antifungal agent 141 can be used for the research of cryptococcal meningitis.
-
Ibrexafungerp citrate (Standard)
0 ImagesCat. No.: HY-107126ARCAS No.: 1965291-08-0Synonyms: MK 3118 citrate (Standard); SCY-078 citrate (Standard)Ibrexafungerp citrate (Standard) (MK 3118 citrate (Standard)) is the analytical standard of Ibrexafungerp (citrate) (HY-107126A). This product is intended for research and analytical applications. Ibrexafungerp citrate (MK 3118 citrate) is an orally active β-1,3-glucan synthesis inhibitor, with potential antifungal activity. Ibrexafungerp citrate is an investigational agent for the treatment of Candida and Aspergillus infections.
-
Cryptosporiopsin A
0 ImagesCat. No.: HY-W748023CAS No.: 1402990-52-6Cryptosporiopsin A, a polyketide with antifungal activity, exhibits motility inhibitory and lytic activities against zoospores of the grapevine downy mildew pathogen Plasmopara viticola.
-
Octacosamicin B
0 ImagesCat. No.: HY-N14527CAS No.: 122005-24-7Octacosamicin B has the function of resisting bacterium, yeast, and filamentous fungus, but the function of resisting bacterium is weak.
-
Ciclopirox olamine (Standard)
0 ImagesSynonyms: Ciclopirox ethanolamine (Standard); HOE 296 (Standard)Ciclopirox (olamine) (Standard) is the analytical standard of Ciclopirox (olamine). This product is intended for research and analytical applications. Ciclopirox olamine (Ciclopirox ethanolamine) is a synthetic and orally active antifungal agent that can be used for superficial mycoses reseaech. Ciclopirox olamine has a very broad spectrum of activity and inhibits dermatophytes, yeasts, molds, and many Gram-positive and Gram-negative species pathogenic. Ciclopirox olamine also has anticancer and anti-inflammatory effect.
-
(S)-Dihydroaeruginoic acid
0 ImagesCat. No.: HY-129316CAS No.: 143209-04-5Synonyms: CGP 52547(S)-Dihydroaeruginoic acid is an antibiotic originally isolated from P. fluorescens. It has antimicrobial activity in a disc assay against R. solani, P. ultimum, B. cinera, S. rolfsii, C. gloeosporioide, F. oxysporum, and S. tritici fungi as well as B. subtilis, E. herbicola, and S. albus bacteria when used at a concentration of 200 μg/disc.
-
Verlamelin
0 ImagesCat. No.: HY-N14856CAS No.: 74758-64-8Verlamelin is a depsipeptide antibiotic. Verlamelin has anti-fungal activity against plant pathogens.
-
Mucidin
0 ImagesCat. No.: HY-W715444CAS No.: 52110-55-1Mucidin is an antifungal antibiotic that inhibits electron-transfer reactions in the cytochrome bc1 complex of the mitochondrial respiratory chain.
-
Inpyrfluxam
0 ImagesInpyrfluxam is a succinate dehydrogenase (SDH) inhibitor. Inpyrfluxam targets the ubiquinone binding pocket of mitochondrial SDH complex subunits ViSDHB, ViSDHC, ViSDHD, interfering with cellular respiration. Inpyrfluxam inhibits conidial germination and mycelial growth of Venturia inaequalis in vitro. Inpyrfluxam can be used for the research of apple scab.
-
Zoxamide (Standard)
0 ImagesCat. No.: HY-120921RCAS No.: 156052-68-5Synonyms: RH-7281 (Standard)Zoxamide (Standard) is the analytical standard of Zoxamide. This product is intended for research and analytical applications. Zoxamide (RH-7281) is an oomycete fungicide. Zoxamide arrests nuclear division in Phytophthora capsici germlings and destroyed the microtubule cytoskeleton.
-
Sinefungin (Standard)
0 ImagesCat. No.: HY-101938RCAS No.: 58944-73-3Synonyms: Adenosyl-Ornithine (Standard); A-9145 (Standard); Antibiotic 32232RP (Standard)Sinefungin (Standard) is the analytical standard of Sinefungin (HY-101938). This product is intended for research and analytical applications. Sinefungin is a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication. Sinefungin, a SET7/9 inhibitor, ameliorates renal fibrosis by inhibiting H3K4 methylation.
-
Antifungal agent 155 hydrochloride
0 ImagesCat. No.: HY-181492Antifungal agent 155 hydrochloride is an antifungal agent. Antifungal agent 155 hydrochloride induces bent, twisted, abnormally swollen hyphae, compromises fungal hyphal plasma membrane integrity, and triggers fungal cell death. Antifungal agent 155 hydrochloride can be used for the research of fusarium keratitis.
-
Clavamycin A
0 ImagesCat. No.: HY-N13994CAS No.: 103059-93-4Clavamycin A has strong anti-candida activity, and its action can be antagonized by dipeptide or tripeptide, but amino acid can not cancel its action. No antibacterial activity and no inhibition of β-lactamase.
