Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.
Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
All Product Categories
-
Fungal Related Products (2719)
Related Products (2719)
-
Antibodies (1)
-
Related Compound Screening Libraries (1)
-
Pencycuron (Standard)
0 ImagesCat. No.: HY-B2048RCAS No.: 66063-05-6Pencycuron (Standard) is the analytical standard of Pencycuron. This product is intended for research and analytical applications. Pencycuron is a benzoylurea fungicide. Pencycuron kills fungi by inhibiting the synthesis of fungal cell walls.Pencycuron can be used in research on the control of fungal diseases on crops, such as sheath blight, powdery mildew and late blight.
-
Aranochlor A
0 ImagesCat. No.: HY-N13951CAS No.: 208466-05-1Aranochlor A is an antibiotic found in Pseudoarachniotus roseus (HIL Y-30499). Aranochlor A exhibits antibacterial and antifungal activities.
-
Phoslactomycin F
0 ImagesCat. No.: HY-N12675CAS No.: 122856-30-8Phoslactomycin F has weak effect against Gram-positive bacteria, but has strong effect against fungi.
-
Arginomycin
0 ImagesCat. No.: HY-N13890CAS No.: 106133-33-9Arginomycin is a nucleoside antibiotic that inhibits the growth of Gram-positive bacteria and fungi in vitro.
-
α-Thujaplicin
0 Imagesα-Thujaplicin, the isomer of Hinokitiol (HY-B2230), is an antimicrobial agent. α-Thujaplicin can be isolated from Aomori Hiba (Thujopsis dolabrata SIEB. et ZUCC. var. hondai MAKINO). α-Thujaplicin shows inhibition of Carboxypeptidase A (IC50: 32.4 μM). α-Thujaplicin shows rather strong antifungal activity against seven kinds of plant-pathogenic fungi, their MICs being in the range of 12.0-50.0 μg/mL. α-Thujaplicin shows clear antibacterial activity against Legionella pneumophila SG 1 and L. pneumophila SG 3, and their MICs are in the range of 12.5-50 μg/mL. α-Thujaplicin shows antibacterial activity against Enterococcus faecalis IFO-12965 with a MIC of 1.56 μg/mL. α-Thujaplicin shows germination inhibition toward the seed of Echinochloa utilis Ohwi et Yabuno. α-thujaplicin inhibits lymphocytic leukemia, stomach cancer, Ehrlich’s ascites carcinoma.
-
Antifungal agent-162
0 ImagesCat. No.: HY-136753CAS No.: 1155361-01-5Antifungal agent-162 (Compound 1c) is an Antifungal agent. Antifungal agent-162 exhibits potent in vitro antifungal activity against Candida albicans, Cryptococcus neoformans, Candida parapsilosis, Candida tropicalis, Candida krusei, and Microsporum gypseum (with MIC80 values ranging from 0.0156 to 0.25 μg/mL), while shows no activity against Aspergillus fumigatus.
-
Pyrrolomycin B
0 ImagesCat. No.: HY-N14575CAS No.: 79763-00-1Pyrrolomycin B is a pyrrole antibiotic. Pyrrolomycin B has anti-Gram-positive bacteria, anti-Gram-negative bacteria and anti-individual fungi activity.
-
Methfuroxam
0 ImagesCat. No.: HY-W714197CAS No.: 28730-17-8Methfuroxam is a fungicide that exhibits extremely high inhibitory activity against three important pathogenic fungi (C. salmonicolor, R. lignosus, Ganoderma sp.) of rubber trees and oil palms.
-
Posaconazole-d3
0 ImagesCat. No.: HY-17373S2Synonyms: SCH 56592-d3Posaconazole-d3 (SCH 56592-d3) is deuterium labeled Posaconazole. Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity.
-
Chitosan-PEG-Cy3
0 ImagesCat. No.: HY-D2430Chitosan-PEG-Cy3 is a fluorescent labeling reagent that combines Cy3 (HY-D0822) fluorescent dye, Chitosan and polyethylene glycol (PEG). The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. Cy3 has an emission maximum around 562-570 nm. Chitosan exhibits antimicrobial activity against various bacteria and fungi.
-
Pramiconazole
0 ImagesSynonyms: Azoline; R126638Pramiconazole is a broad-spectrum antifungal agent with oral activity. Pramiconazole has a good affinity for 14α-demethylase. Pramiconazole can be used in the study of fungal infections in the local skin, hair, nails, oral cavity, and genital mucosa.
-
Fenhexamid (Standard)
0 ImagesSynonyms: KBR 2738 (Standard)Fenhexamid (Standard) is the analytical standard of Fenhexamid. This product is intended for research and analytical applications. Fenhexamid, a botryticide, is a sterol biosynthesis inhibitor. Fenhexamid shows fungicide efficient against the plant pathogenic fungus Botryotinia fuckeliana (Botrytis cinerea).
-
Antifungal agent 150
0 ImagesCat. No.: HY-W281071CAS No.: 67365-93-9Antifungal agent 150 is an antifungal agent with activity against phytopathogenic fungi and in planta lesion suppression. Antifungal agent 150 inhibits ergosterol biosynthesis via targeted enzyme interaction. Antifungal agent 150 can be used for the research of plant diseases caused by Rhizoctonia solani, including banded leaf and sheath blight of maize.
-
1-Dodecylimidazole (Standard)
0 ImagesCat. No.: HY-138540RCAS No.: 4303-67-7Synonyms: N-Dodecylimidazole (Standard)1-Dodecylimidazole (Standard) is the analytical standard of 1-Dodecylimidazole. This product is intended for research and analytical applications. 1-Dodecylimidazole (N-Dodecylimidazole) is a lysosomotropic detergent and a cytotoxic agent. 1-Dodecylimidazole causes cell death by its acid-dependent accumulation in lysosomes, disruption of the lysosomal membrane, and releaseof cysteine proteases into the cytoplasm. 1-Dodecylimidazole has hypocholesterolaemic activity and broad-spectrum antifungal activity.
-
SDH-IN-30
0 ImagesCat. No.: HY-178050SDH-IN-30 (Compound 7m) is a Succinate dehydrogenase (SDH) inhibitor with an IC50 of 0.34 μM. SDH-IN-30 has potent antifungal activities against Rhizoctonia solani and Sclerotinia sclerotiorum with EC50 s of 0.004 and 0.028 μg/mL. SDH-IN-30 also has remarkable protective and curative efficacies against R. solani and significantly inhibits S. sclerotiorum growth on oilseed rape leaves by damaging the fungal cell structure. SDH-IN-30 can be used for fungal infections like rice sheath blight (RSB) and sclerotinia stem rot (SSR) research.
-
Mps1-IN-9
0 ImagesCat. No.: HY-168155Mps1-IN-9 (compound M-12) is an Mps1-targeted inhibitor discovered for broad-spectrum antifungal agents..
-
MFB-1041
0 ImagesCat. No.: HY-125694CAS No.: 151856-47-2MFB-1041 is an orally active antifungal agent, but exhibits poor oral absorption. MFB-1041 induces the binding of drug to serum albumin.
-
Concanamycin F
0 ImagesCat. No.: HY-N14426CAS No.: 144539-92-4Concanamycin F has antifungal, antiviral, immunosuppressive, cytotoxic and other activities, and is a specific inhibitor of V-type ATPase (Ki=0.02 nM), which is an important tool for biochemical research.
-
Curvulol
0 ImagesCat. No.: HY-N15595CAS No.: 15817-76-2Curvulol is an antimicrobial agent with a polyketide structure. Curvulol can be isolated from Taxus baccata ( Chaetosphaeronema achilleae). Curvulol has a significant cytotoxicity against L929 and KB-3-1 cells, and strongly inhibits Staphylococcus aureus biofilm formation with a MIC of 64 μg/mL.
