Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.
Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
All Product Categories
-
Fungal Related Products (2719)
Related Products (2719)
-
Antibodies (1)
-
Related Compound Screening Libraries (1)
-
Pyraoxystrobin
0 ImagesCat. No.: HY-W715372CAS No.: 862588-11-2Pyraoxystrobin is a QoI fungicide, with an EC50 of 0.0094 μg/mL for M. oryzae isolates. Pyraoxystrobin can be used for the research of M. oryzae in rice fields.
-
Group II intron-IN-1
0 ImagesCat. No.: HY-170885CAS No.: 836644-25-8Group II intron-IN-1 (Compound 1) is an inhibitor of fungal Group II introns, with an IC50 of 3 μM. Group II intron-IN-1 can be used for research on infections caused by fungi such as Candida.
-
Bis(4-morpholinyl)methane
0 ImagesCat. No.: HY-W175598CAS No.: 5625-90-1Synonyms: N,N'-Methylene-bis-morpholineBis(4-morpholinyl)methane (N,N'-Methylene-bis-morpholine) is a broad-spectrum, slow-release formaldehyde-based fungicide. Bis(4-morpholinyl)methane inhibits the growth and reproduction of microorganisms, and prevents spoilage and odor generation in humid environments. Bis(4-morpholinyl)methane serves as a preservative for natural rubber latex.
-
Antifungal agent 89
0 ImagesCat. No.: HY-161049CAS No.: 3036399-40-0Antifungal agent 89 (compound 28) is a antifungal agent against Cryptococcus neoformans with minimum inhibitory concentration value ranging from 0.8 to 52.17 μM.
-
Epoformin
0 ImagesCat. No.: HY-N14220CAS No.: 52146-62-0Epoformin, is a fungal cyclohexene epoxide that can be isolated from Diplodia quercivora. Epoformin is an antibiotic and exhibits weak inhibitory activity against rye seedling sheath growth. Epoformin exhibits antifungal activity, inhibits Phytophthora cinnamomi and Phytophthora plurivora.
-
SDH-IN-40
0 ImagesCat. No.: HY-179139SDH-IN-40 (compound A7) is a succinate dehydrogenase inhibitor (SDHI). SDH-IN-40 exhibits strong inhibitory effects on F. graminearum (IC50 = 34.33 μM). SDH-IN-40 can be used for research on fungal infections.
-
Epelmycin A
0 ImagesCat. No.: HY-N14155CAS No.: 107807-25-0Epelmycin A has anti-Gram positive, negative bacteria and candida albicans activity, and has anti-leukemic L1210 activity, which is stronger than Aclacinomycin.
-
ECDG
0 ImagesCat. No.: HY-184103CAS No.: 378230-75-2Synonyms: Ethylenedicysteine deoxyglucoseECDG is a small-molecule compound dependent on α-ketoglutarate/Fe2+ that participates in the biosynthesis of echinocandins. ECDG is involved in the targeted transport of glucose, and can be used for PET imaging after labeling with radioactive atoms. ECDG increases blood glucose levels in rats, undergoes cellular uptake mediated by D-glucose, localizes in ischemic viable myocardial tissue, and accumulates in the synovial space of rheumatoid arthritis. ECDG can be used in research related to candidiasis, glucose metabolism disorders, fungal infections, myocardial ischemia and rheumatoid arthritis.
-
Mafenide Acetate (Standard)
0 ImagesMafenide (Acetate) (Standard) is the analytical standard of Mafenide Acetate (HY-B0614A). This product is intended for research and analytical applications. Mafenide Acetate is a potent sulfonamide antimicrobial agent. Mafenide Acetate exhibits antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa. Mafenide Acetate also exhibits antifungal activity against filamentous fungi (e.g., Lichtheimia and Aspergillus flavus). Mafenide Acetate can be used in the research of skin grafts on burn wounds, post-traumatic invasive fungal infections, and bacterially contaminated wounds.
-
(Gly0.8Nap0.2)20
0 ImagesCat. No.: HY-161457(Gly0.8Nap0.2)20 is a compound that dual targets fungal membranes and DNA. (Gly0.8Nap0.2)20 has antibacterial activity.
-
Neocryptolepine-Cl
0 ImagesCat. No.: HY-173342CAS No.: 1150313-15-7Synonyms: Cryptotackieine-ClNeocryptolepine-Cl (compound Z24) is an inhibitor of Bcthi4 and exhibits excellent antifungal activity against B. cinerea with EC50 value of 0.56 μg/mL.
-
SDH-IN-34
0 ImagesCat. No.: HY-178457SDH-IN-34 is a Succinate Dehydrogenase inhibitor with antifungal activity. SDH-IN-34 can be used for the research of infection.
-
Moracin B
0 ImagesCat. No.: HY-N12497CAS No.: 67259-16-9Moracin B is a phytoalexin with antifungal activity. Moracin B can be isolated from the cortex and phloem tissues of mulberry (Morus alba Linne) infected with Fusarium solani f. sp. mori. Moracin B can be used to study plant disease resistance mechanisms against microbial infections, particularly showing potential application value in the field of plant disease control.
-
CYP51-IN-23-d3
0 ImagesCat. No.: HY-174353SCYP51-IN-23-d3 is a potent and broad-spectrum CYP51 inhibitor with a MIC80 of 1 μg/mL against Aspergillus fumigatum. CYP51-IN-23-d3 can prevent fungal phase transformation and biofilm formation. CYP51-IN-23-d3 exhibits anti-drug resistance activity and fungal activity, and shows excellent safety for cells and significant pharmacological activity in mice. CYP51-IN-23-d3 can be used for the study of invasive fungal infections (IFIs).
-
Triadimenol-d4
0 ImagesCat. No.: HY-B0851SCAS No.: 2121989-56-6Triadimenol-d4 is the deuterium labeled Triadimenol. Triadimenol is a triazole fungicide and has been widely used in agriculture. Triadimenol has certain toxicity to animals.
-
Destomycin B
0 ImagesCat. No.: HY-138194CAS No.: 11005-98-4Synonyms: A-16316-CDestomycin B (A-16316-C) is an antibiotic, and is active against fungi. Destomycin B also has anthelmintic activity.
-
Lanomycin
0 ImagesCat. No.: HY-118451CAS No.: 141363-91-9Lanomycin is an antifungal compound with activity against Candida and dermatophytes.
-
8-Acetylverrucarin L
0 ImagesCat. No.: HY-N13025CAS No.: 77101-88-3Synonyms: Verrucarin L acetate8-Acetylverrucarin L (Verrucarin L acetate) is a mycotoxin, which exhibits antitumor and antimicrobial activities. 8-Acetylverrucarin L exhibits cytotoxicity to cancer cells HCT116 and A2780S, with IC100 of 9.77 and 9.77 ng/mL. 8-Acetylverrucarin L exhibits antifungal activity against Saccharomyces cerevisiae, Candida albicans and Geotrichum candidum.
-
2-Methylheptanoic acid (Standard)
0 ImagesCat. No.: HY-W015664RCAS No.: 1188-02-92-Methylheptanoic acid (Standard) is the analytical standard of 2-Methylheptanoic acid (HY-W015664). This product is intended for research and analytical applications. 2-Methylheptanoic acid is a naturally occurring branched-chain medium-chain fatty acid with fumigant activity against Aspergillus flavus. 2-Methylheptanoic acid inhibits the growth of Aspergillus flavus and kills its spores via two modes of action, namely fumigation and direct contact, with its fumigant activity being stronger than its direct contact activity. 2-Methylheptanoic acid can be used in studies related to Aspergillus flavus infection.
