Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.
Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
All Product Categories
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Fungal Related Products (2720)
Related Products (2720)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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Oomycete-IN-1
0 ImagesCat. No.: HY-175038CAS No.: 2945180-71-0Oomycete-IN-1 (Compound X4) is a selective inhibitor targeting the PH domain of PcORP1 in Phytophthora species. Oomycete-IN-1 shows EC50 values ranging from 1 to 4 μg/mL against six oomycetes. Oomycete-IN-1 disrupts lipid transport and metabolism, leading to mycelium hyperplasia and cell membrane ruffling in P. capsici. Oomycete-IN-1 can be used in the research of preventing and controlling oomycete diseases (such as P. capsici infection).
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5,7-Dihydroxy-4-methylcoumarin (Standard)
0 Images5,7-Dihydroxy-4-methylcoumarin (Standard) is the analytical standard of 5,7-Dihydroxy-4-methylcoumarin. This product is intended for research and analytical applications. 5,7-Dihydroxy-4-methylcoumarin is a coumarin derivative from Mexican tarragon. 5,7-Dihydroxy-4-methylcoumarin possesses antifungal and antibacterial activities.
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Antimicrobial agent-42
0 ImagesCat. No.: HY-175699Antimicrobial agent-42 (Compound 6j) is an antimicrobial agent. Antimicrobial agent-42 interacts with key amino acids such as Lys59 and Ser170 within the ALS3 protein, crucial for the binding of host peptides. Antimicrobial agent-42 significantly inhibits Candida albicans biofilm formation and reduces planktonic cells aggregation and hyphal formation. Antimicrobial agent-42 has an antifungal activity, promising for fungal infections reseach.
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CYP51-IN-2
0 ImagesCat. No.: HY-136752CAS No.: 1155361-00-4CYP51-IN-2 (compound 1b), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows 64 and 128 times higher activity than that of Fluconazole against Microsporum gypseum and Candida albicans, respectively.
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Rhizocticin A
0 ImagesCat. No.: HY-126770CAS No.: 114301-25-6Rhizocticin A is an antifungal phosphono-oligopeptide against Ascodesmis, Plicaria, Rhizoctonia with MIC of 3.5 μg/mL. Rhizocticin A produces toxic L-2-Amino-5-phospho-3-cis-pentenoic acid (L-APPA), which may interfere with cell metabolism.
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Leucomycin A5
0 ImagesCat. No.: HY-125569CAS No.: 18361-45-0Leucomycin A5 has antifungal activity, with the MIC for Staphylococcus pyogenes pen S, Staphylococcus pyogenes pen R, and Staphylococcus faecalis being 0.8, 3.2, and 0.8 μg/mL, respectively.
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3-Amino-1,2,4-triazin-5(2H)-one
0 ImagesCat. No.: HY-W167979CAS No.: 1121-90-03-Amino-1,2,4-triazin-5(2H)-one is an organic compound belonging to the triazine family. 3-Amino-1,2, 4-Triazin-5 (2H)-one and its derivatives may have a variety of biological activities, such as antibacterial, antifungal, antiviral, or antitumor but the specific activity depends on its chemical structure and functional groups. 3-Amino-1,2, 4-Triazin-5 (2H)-one is a lead compound with a wide range of applications.
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(+)-Columbianetin acetate (Standard)
0 ImagesCat. No.: HY-N0363ARCAS No.: 23180-65-6Synonyms: (S)-Columbianetin acetate (Standard)(+)-Columbianetin acetate (Standard) is the analytical standard of (+)-Columbianetin acetate (HY-N0363A). This product is intended for research and analytical applications. (+)-Columbianetin acetate ((S)-Columbianetin) acts as an inhibitor of JNK/ERK. (+)-Columbianetin acetate inhibits UVA-induced phosphorylation of JNK and ERK, reduces the production of MMP-1, reverses UVA-induced Collagen (HY-NP003) degradation, and alleviates UVA-mediated inhibition of Smad2/3 phosphorylation and translocation. (+)-Columbianetin acetate regulates the AP-1 and ASK1-MAPK signaling pathways, inhibits the production of ROS and blocks sub-G1 cell cycle arrest. (+)-Columbianetin acetate is applicable to research related to skin aging.
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Albiducin A
0 ImagesCat. No.: HY-N15343CAS No.: 2222286-14-6Albiducin A is an antibiotic found in Hymenoscyphus albidus, exhibiting antibacterial and anticancer activities. The MIC range of Albiducin A against bacteria and fungi is 16.7-66.7 mg/mL. Its IC50 values for mouse fibroblast cell line (L929) and human cervical carcinoma cell line (KB3-1) are 6.1 and 2.7 μg/mL, respectively. Albiducin A holds promise for research in the fields of infection and cancer diseases.
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Iprovalicarb
0 ImagesCat. No.: HY-121766CAS No.: 140923-17-7Synonyms: Fencaramid; SZX-0722Iprovalicarb (Fencaramid; SZX-0722) is a fungicide that can be used for the study of fungal diseases in the wine sector.
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D13
0 ImagesCat. No.: HY-W514721CAS No.: 321945-27-1D13, an Acylhydrazones derivative, possesses antifungal activity. D13 is effective against murine sporotrichosis.
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Ametoctradin (Standard)
0 ImagesCat. No.: HY-W714076RCAS No.: 865318-97-4Ametoctradin (Standard) is the analytical standard of Ametoctradin. This product is intended for research and analytical applications. Ametoctradin is a potent Qo site inhibitor of bc1 complex in mitochondrial respiration. Ametoctradin is a highly selective and effective Oomycete-specific fungicide that can be used against late blight and downy mildews.
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Prothioconazole (Standard)
0 ImagesCat. No.: HY-116568RCAS No.: 178928-70-6Synonyms: JAU-6476 (Standard)Prothioconazole (Standard) is the analytical standard of Prothioconazole. This product is intended for research and analytical applications. Prothioconazole is a triazolinthione fungicide. Prothioconazole is a CYP51 inhibitor.
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Haliangicin B
0 ImagesCat. No.: HY-N14442CAS No.: 661466-85-9Haliangicin B has anti-filamentous fungi activity, and it also has effect on oomycetes, but has no antibacterial activity.
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Epelmycin E
0 ImagesCat. No.: HY-N14159CAS No.: 76264-93-2Epelmycin E has anti-Gram positive, negative bacteria and candida albicans activity, and has anti-leukemic L1210 activity, which is stronger than Aclacinomycin.
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Terrestribisamide
0 ImagesCat. No.: HY-N12267ACAS No.: 91000-13-4Synonyms: (E)-N,N′-DiferuloylputrescineTerrestribisamide ((E)-N,N′-Diferuloylputrescine) can be isolated from dried fruits of Tribulus terrestris. Terrestribisamide has antibacterial, antifungal, antioxidant, anticancer effects.
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Pneumocandin C0
0 ImagesCat. No.: HY-N14990CAS No.: 144074-96-4Pneumocandin C0 is the isomer of Pneumocandin B0 (HY-17578) with antifungal activity, which is found by carrying out fermentations of Glarea lozoyensis at a high residual fructose concentration.
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Methyl 3-(2-nitrophenyl)acrylate
0 ImagesCat. No.: HY-W1058381CAS No.: 612-43-1Methyl 3-(2-nitrophenyl) acrylate is an antifungal agent. Methyl 3-(2-nitrophenyl) acrylate exhibits activity against Candida albicans strains. Methyl 3-(2-nitrophenyl) acrylate can be used in research related to Candida albicans infections.
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BHBM
0 ImagesCat. No.: HY-156195CAS No.: 302807-84-7BHBM (compound 1) is an aromatic acylhydrazone antifungal agent with high bactericidal activity against Cryptococcus neoformans.
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YZK-C22
0 ImagesCat. No.: HY-163634CAS No.: 1111646-44-6YZK-C22, containing a 1,2,3-thiadiazol-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole skeleton, is a fungicide lead compound with broad-spectrum fungicidal activity.
