2107-76-8
Chemical Structure
5,7-Dihydroxy-4-methylcoumarin
- CAS No.: 2107-76-8
- Formula:C10H8O4
- Molecular Weight:192.17
IUPAC Name: 5,7-dihydroxy-4-methyl-2H-chromen-2-one
InChIKey: QNVWGEJMXOQQPM-UHFFFAOYSA-N
SMILES: O=C1C=C(C)C2=C(O)C=C(O)C=C2O1
Biological Activity: 5,7-Dihydroxy-4-methylcoumarin is an antioxidant. 5,7-Dihydroxy-4-methylcoumarin protects mouse cochlear hair cells from Cisplatin-induced damage, enhances cell viability and inhibits apoptosis. 5,7-Dihydroxy-4-methylcoumarin downregulates phosphorylated JNK levels, increases the ratio of phosphorylated FoxO1 to total FoxO1, scavenges free radicals, reduces ROS accumulation, maintains mitochondrial membrane potential and alleviates mitochondrial dysfunction. 5,7-Dihydroxy-4-methylcoumarin downregulates the expression of caspase-3 and improves cell viability. 5,7-Dihydroxy-4-methylcoumarin can be used in studies related to ototoxicity[1][2].
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5,7-Dihydroxy-4-methylcoumarin | 98.85% | 5,7-Dihydroxy-4-methylcoumarin is an antioxidant. 5,7-Dihydroxy-4-methylcoumarin protects mouse cochlear hair cells from Cisplatin-induced damage, enhances cell viability and inhibits apoptosis. 5,7-Dihydroxy-4-methylcoumarin downregulates phosphorylated JNK levels, increases the ratio of phosphorylated FoxO1 to total FoxO1, scavenges free radicals, reduces ROS accumulation, maintains mitochondrial membrane potential and alleviates mitochondrial dysfunction. 5,7-Dihydroxy-4-methylcoumarin downregulates the expression of caspase-3 and improves cell viability. 5,7-Dihydroxy-4-methylcoumarin can be used in studies related to ototoxicity. | ||||||||||||||||||||
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5,7-Dihydroxy-4-methylcoumarin (Standard) | ≥98% | 5,7-Dihydroxy-4-methylcoumarin (Standard) is the analytical standard of 5,7-Dihydroxy-4-methylcoumarin. This product is intended for research and analytical applications. 5,7-Dihydroxy-4-methylcoumarin is a coumarin derivative from Mexican tarragon. 5,7-Dihydroxy-4-methylcoumarin possesses antifungal and antibacterial activities. | ||||||||||||||||||||
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References
- [1]. Li C, et al. 5,7-Dihydroxy-4-methylcoumarin modulates the JNK/FoxO1 signaling pathway to attenuate cisplatin-induced ototoxicity by suppressing oxidative stress and apoptosis in vitro. Biochim Biophys Acta Mol Cell Res. 2023;1870(4):119437. [Content Brief]
- [2]. Céspedes CL, et al. Antifungal and antibacterial activities of Mexican tarragon (Tagetes lucida). J Agric Food Chem. 2006;54(10):3521-3527. [Content Brief]
