ECDG
ECDG is a small-molecule compound dependent on α-ketoglutarate/Fe2+ that participates in the biosynthesis of echinocandins. ECDG is involved in the targeted transport of glucose, and can be used for PET imaging after labeling with radioactive atoms. ECDG increases blood glucose levels in rats, undergoes cellular uptake mediated by D-glucose, localizes in ischemic viable myocardial tissue, and accumulates in the synovial space of rheumatoid arthritis. ECDG can be used in research related to candidiasis, glucose metabolism disorders, fungal infections, myocardial ischemia and rheumatoid arthritis.
For research use only. We do not sell to patients.
- CAS No.: 378230-75-2
- Formula: C20H38N4O12S2
- Molecular Weight:590.67
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
ECDG (1.0 mg/mL; 3 minutes) undergoes hexokinase-catalyzed phosphorylation, as demonstrated by a positive signal at 341.5 nm in the cell-free hexokinase assay[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Fischer 344 (female, 145-155 g, healthy; female, 250-275 g, inoculated subcutaneously with 13762 mammary tumor cells)[2]
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Dosage:1.2 mM/kg
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Administration:i.v. (ECDG, 99mTc ECDG, unlabeled FDG); i.m. (insulin); single dose
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Result:Increased blood glucose levels in healthy rats, which dropped to ~20 mg/dL by 180 minutes post-insulin injection.
Recorded mean tumor-to-nontumor ROI ratios of 1.70 (immediate), 1.58 (30 minutes), and 1.82 (2 hours) for 3 mm tumors, and 2.36 (immediate), 2.41 (30 minutes), and 2.88 (2 hours) for 6 mm tumors.
Reduced tumor uptake of 99mTc ECDG by 40% following unlabeled FDG pretreatment.
Increased tumor uptake of 99mTc ECDG by 60% following insulin pretreatment.
Enabled better breast tumor visualization than 99mTc ethylenedicysteine at equivalent time points.
Chemical Information
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CAS No. 378230-75-2
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Molecular Weight 590.67
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Formula C20H38N4O12S2
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SMILES
OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](C=O)NC([C@H](CS)NCCN[C@@H](CS)C(N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO)=O)=O
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Synonyms
Ethylenedicysteine deoxyglucose
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Jiang W, et al. EcdGHK are three tailoring iron oxygenases for amino acid building blocks of the echinocandin scaffold. Journal of the American Chemical Society. 2013 Mar 20;135(11):4457-66. [Content Brief]
[2]. Yang DJ, et al. Imaging with 99mTc ECDG targeted at the multifunctional glucose transport system: feasibility study with rodents. Radiology. 2003 Feb;226(2):465-73. [Content Brief]
[3]. Liu W, et al. Structural Characterization of the l-Homo-Tyrosine β-Hydroxylase EcdG Involved in Echinocandin Biosynthesis Guides the Engineering of Its Homologous Protein GloM. Journal of natural products. 2026 Jun 17. [Content Brief]
[5]. Evbuomwan O, et al. The Biodistribution and Utility of Tc-Ethylenedicysteine-Deoxyglucose (Tc-Glucosamine) in the Identification of Active Disease in Patients with Rheumatoid Arthritis-a Single Center Prospective Study. Nuclear medicine and molecular imaging. 2024 Apr;58(2):52-61. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ECDG Related Classifications
HY-184103 Related Classifications
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