378230-75-2
Chemical Structure
ECDG
Synonym(s): Ethylenedicysteine deoxyglucose
- CAS No.: 378230-75-2
- Formula:C20H38N4O12S2
- Molecular Weight:590.67
InChIKey: HQASPCIGXITHBD-QQUALSNWSA-N
SMILES: OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](C=O)NC([C@H](CS)NCCN[C@@H](CS)C(N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO)=O)=O
Biological Activity: ECDG is a small-molecule compound dependent on α-ketoglutarate/Fe2+ that participates in the biosynthesis of echinocandins. ECDG is involved in the targeted transport of glucose, and can be used for PET imaging after labeling with radioactive atoms. ECDG increases blood glucose levels in rats, undergoes cellular uptake mediated by D-glucose, localizes in ischemic viable myocardial tissue, and accumulates in the synovial space of rheumatoid arthritis. ECDG can be used in research related to candidiasis, glucose metabolism disorders, fungal infections, myocardial ischemia and rheumatoid arthritis[1][2][3][4][5].
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ECDG | ECDG is a small-molecule compound dependent on α-ketoglutarate/Fe2+ that participates in the biosynthesis of echinocandins. ECDG is involved in the targeted transport of glucose, and can be used for PET imaging after labeling with radioactive atoms. ECDG increases blood glucose levels in rats, undergoes cellular uptake mediated by D-glucose, localizes in ischemic viable myocardial tissue, and accumulates in the synovial space of rheumatoid arthritis. ECDG can be used in research related to candidiasis, glucose metabolism disorders, fungal infections, myocardial ischemia and rheumatoid arthritis. | |||||||||||||||||||||
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- [1]. Jiang W, et al. EcdGHK are three tailoring iron oxygenases for amino acid building blocks of the echinocandin scaffold. Journal of the American Chemical Society. 2013 Mar 20;135(11):4457-66. [Content Brief]
- [2]. Yang DJ, et al. Imaging with 99mTc ECDG targeted at the multifunctional glucose transport system: feasibility study with rodents. Radiology. 2003 Feb;226(2):465-73. [Content Brief]
- [3]. Liu W, et al. Structural Characterization of the l-Homo-Tyrosine β-Hydroxylase EcdG Involved in Echinocandin Biosynthesis Guides the Engineering of Its Homologous Protein GloM. Journal of natural products. 2026 Jun 17. [Content Brief]
- [4]. Broisat A, et al. Detection of a prior episode of myocardial ischemia using the metabolic tracer TC99M-ethylenedicysteine D-glucosamine (ECDG) in a canine model of ischemic memory. J Am Coll Cardiol. 2011;57(14 Suppl):E688.
- [5]. Evbuomwan O, et al. The Biodistribution and Utility of Tc-Ethylenedicysteine-Deoxyglucose (Tc-Glucosamine) in the Identification of Active Disease in Patients with Rheumatoid Arthritis-a Single Center Prospective Study. Nuclear medicine and molecular imaging. 2024 Apr;58(2):52-61. [Content Brief]
Keywords
