144539-92-4
144539-92-4
Chemical Structure
Concanamycin F
- CAS No.: 144539-92-4
- Formula:C39H64O10
- Molecular Weight:692.92
InChIKey: YNZXLMPHTZVKJN-VBKCWIKWSA-N
SMILES: O=C1O[C@H]([C@@H](C)[C@@H](O)[C@@H]([C@@]2(O)C[C@@H](O)[C@H](C)[C@@H](/C=C/C)O2)C)[C@@H](OC)/C=C/C=C(C)/C[C@@H](C)[C@H](O)[C@H](CC)[C@H](O)[C@H](C)/C=C(C)/C=C1\OC
Biological Activity: Concanamycin F has antifungal, antiviral, immunosuppressive, cytotoxic and other activities, and is a specific inhibitor of V-type ATPase (Ki=0.02 nM), which is an important tool for biochemical research[1].
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Concanamycin F | Concanamycin F has antifungal, antiviral, immunosuppressive, cytotoxic and other activities, and is a specific inhibitor of V-type ATPase (Ki=0.02 nM), which is an important tool for biochemical research. | |||||||||||||||||||||
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References
- [1]. I Paterson I, et al. Total Synthesis of (+)-Concanamycin F We thank the EPSRC (GR/K54052), Knoll Pharmaceuticals (CASE Studentship to V.A.D.), the Cambridge Commonwealth Trust (M.D.M.), and Merck for support, and Dr R. Norrie (Knoll Pharmaceuticals) for helpful discussions. We also thank Prof. A. Zeeck (Göttingen) for kindly providing copies of (1)H NMR spectra of concanamycin F (concanolide A). Angew Chem Int Ed Engl. 2000 Apr;39(7):1308-1312. [Content Brief]
