129046-69-1
Chemical Structure
IKD-8344
- CAS No.: 129046-69-1
- Formula:C48H76O12
- Molecular Weight:845.11
InChIKey: MXPYTLCDIMCGEQ-BINRNISCSA-N
SMILES: C[C@@H]([C@@](CC1)([H])O[C@@H]1C)[C@@](OC([C@H]([C@@]2([H])O[C@@H](CC([C@@H]([C@](CC3)([H])O[C@]3([H])C4)C)=O)CC2)C)=O)([H])C[C@@]5([H])O[C@]([C@H](C(C[C@@H]6O[C@@]([C@@H](C(O[C@@]4([H])[C@H]([C@@](CC7)([H])O[C@@H]7C)C)=O)C)([H])CC6)=O)C)([H])CC5
Biological Activity: IKD-8344 is a macrocyclic dilactone originally isolated from an actinomycete species and has diverse biological activities, including anticancer, antimicrobial, and anthelmintic properties. It is cytotoxic to L5178Y murine leukemia cells (IC50=0.54 ng/ml).1 IKD-8344 inhibits growth of the mycelial form of C. albicans (MIC=6.25 μg/mL) and potentiates the activity of polymyxin B against the multidrug-resistant pathogenic bacterium B. cenocepacia.
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IKD-8344 | IKD-8344 is a macrocyclic dilactone originally isolated from an actinomycete species and has diverse biological activities, including anticancer, antimicrobial, and anthelmintic properties. It is cytotoxic to L5178Y murine leukemia cells (IC50=0.54 ng/ml).1 IKD-8344 inhibits growth of the mycelial form of C. albicans (MIC=6.25 μg/mL) and potentiates the activity of polymyxin B against the multidrug-resistant pathogenic bacterium B. cenocepacia. | |||||||||||||||||||||
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