2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Glycine Receptor (GlyR)

Glycine Receptor (GlyR)

Glycine Receptor

Glycine Receptor (GlyR) is a ligand-gated chloride ion channel. GlyR can specifically bind to the neurotransmitter glycine, mediate the influx of chloride ions, thereby generating inhibitory postsynaptic potentials and regulating the excitability of neurons. GlyR can be activated by a series of simple amino acids, such as glycine, alanine, and taurine. GlyR is involved in various physiological functions such as sensory information processing, motor control, pain perception, and cognition, and plays a crucial role in the process of neural signal transmission. Abnormal functions of GlyR are associated with multiple neurodevelopment-related disorders, such as autism and epilepsy[1].

Glycine Receptor (GlyR) Related Products (5):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W975902
    MDL-27531
    		Agonist
    MDL-27531 acts functionally like a glycine agonist. MDL-27531 selectively reduces hindlimb contractions. MDL-27531 selectively reverses strychnine-induced seizures in mice. MDL-27531 inhibits pentylenetetrazol-induced seizures with an ED50 of 55 mg/kg. MDL-27531 promotes the binding of benzodiazepine antagonist Ro 15-1788 to cerebral cortex of mice without changing GABA levels. MDL-27531 can be studied in research on reflex control dysfunction.
    MDL-27531
  • HY-106969A
    ZD 9379 sodium
    		Antagonist
    ZD 9379 sodium is a competitive glycine/NMDA receptor antagonist, with an IC50 value of 75 nM (glutamate site). ZD 9379 sodium selectively antagonizes the glycine binding site (GlyB site) on the NMDA receptor, inhibiting the binding of glycine to the NMDA receptor and alleviating excitotoxicity. ZD 9379 sodium reduces the frequency of cortical spreading depression (SDs), alleviates energy depletion in the ischemic penumbra, and delays the expansion of infarction. ZD 9379 sodium reduces the infarct volume and improves neurological function in mouse models. ZD 9379 sodium can be used in studies of acute ischemic stroke, etc.
    ZD 9379 sodium
  • HY-46286
    TTFB
    		Control
    TTFB (N-(4-tert-butyl-1,3-thiazol-2-yl)-3-fluorobenzamide) is a selective, non-competitive zinc-activated channel (ZAC) antagonist. TTFB inhibits Zn2+- and H+-induced ZAC currents with IC50 values of 3 μM and 8.5 μM, respectively, and has an IC50 of 4.7 μM against spontaneous activity. TTFB shows no significant agonistic, antagonistic or modulatory activity towards representative classical Cys-loop receptors including m5-HT3AR, hα3β4 nAChR, hα1β2γ2S GABAAR and hα1 GlyR. TTFB can be used to investigate the physiological and pathological functions of ZAC.
    TTFB
  • HY-181351
    PSN09
    		Agonist
    PSN09 is a blood-brain barrier-permeable agonist of PSAM4-GlyR and PSAM4-5-HT3 receptors with high affinity. 18F-labeled PSN09 serves as a radiotracer for PET imaging in non-human primates.
    PSN09
  • HY-183910
    Pitrazepin
    		Antagonist
    Pitrazepin is a GABAA receptor antagonist and glycine receptor antagonist. Pitrazepin blocks synaptic GABA action, induces neuronal bursting and reduces inhibitory postsynaptic potentials. Pitrazepin can be used in research on depression and psychosis.
    Pitrazepin