90685-01-1
90685-01-1
Chemical Structure
Pitrazepin
- CAS No.: 90685-01-1
- Formula:C19H19N5
- Molecular Weight:317.39
InChIKey: GXFWOMYQHNODFA-UHFFFAOYSA-N
SMILES: C1(N2CCNCC2)=NN=C3N1C4=C(C=CC=C4)CC5=C3C=CC=C5
Biological Activity: Pitrazepin is a GABAA receptor antagonist and glycine receptor antagonist. Pitrazepin blocks synaptic GABA action, induces neuronal bursting and reduces inhibitory postsynaptic potentials. Pitrazepin can be used in research on depression and psychosis[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Pitrazepin | Pitrazepin is a GABAA receptor antagonist and glycine receptor antagonist. Pitrazepin blocks synaptic GABA action, induces neuronal bursting and reduces inhibitory postsynaptic potentials. Pitrazepin can be used in research on depression and psychosis. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Rognan D, et al. Structure and molecular modeling of GABAA receptor antagonists. J Med Chem. 1992 May 29;35(11):1969-77. [Content Brief]
- [2]. Braestrup C, et al. Interaction of pitrazepin with the GABA/benzodiazepine receptor complex and with glycine receptors. Eur J Pharmacol. 1985;118(1-2):115-121. [Content Brief]
- [3]. Demuro A, et al. Antagonistic action of pitrazepin on human and rat GABA(A) receptors. Br J Pharmacol. 1999;127(1):57-64. [Content Brief]
- [4]. Gähwiler BH, et al. Pitrazepin, a novel GABAA antagonist. Neurosci Lett. 1984;45(3):311-316. [Content Brief]
Keywords
